
                                SEQUENCE LISTING

<110> The Regents of the University of California
      Salmon, Kirsty
      Roth, David
      Hatfield, G. Wesley
      Dou, Yimeng

<120> CELLULOSE- AND HEMICELLULOSE-DEGRADATION
  ENZYME-ENCODING NUCLEOTIDE SEQUENCES WITH REFINED
  TRANSLATIONAL KINETICS AND METHODS OF MAKING SAME
  

<130> UCI005.028VPC

<150> US 60/947496        
<151> 2007-07-02  

<150> US 60/947617        
<151> 2007-07-02  

<150> US 60/947784        
<151> 2007-07-03  

<150> US 60/947086        
<151> 2007-06-29  

<150> US 60/947277        
<151> 2007-06-29  

<150> US 60/947329        
<151> 2007-06-29  

<160> 204

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1416
<212> DNA
<213> T. reesi

<220> 
<221> CDS            
<222> (1)...(1416)

<400> 1
atg att gtc ggc att ctc acc acg ctg gct acg ctg gcc aca ctc gca   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct agt gtg cct cta gag gag cgg caa gct tgc tca agc gtc tgg ggc   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggc cag aat tgg tcg ggt ccg act tgc tgt gct tcc gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
agc aca tgc gtc tac tcc aac gac tat tac tcc cag tgt ctt ccc ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca agc tca agc tcg tcc acg cgc gcc gcg tcg acg act tct cga   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gta tcc ccc aca aca tcc cgg tcg agc tcc gcg acg cct cca cct ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act acc aga gta cct cca gtc gga tcg gga acc gct acg tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tca ggc aac cct ttt gtt ggg gtc act cct tgg gcc aat gca tat tac   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gcc tct gaa gtt agc agc ctc gct att cct agc ttg act gga gcc atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gcc act gct gca gca gct gtc gca aag gtt ccc tct ttt atg tgg cta   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act ctt gac aag acc cct ctc atg gag caa acc ttg gcc gac atc   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
cgc acc gcc aac aag aat ggc ggt aac tat gcc gga cag ttt gtg gtg   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gac ttg ccg gat cgc gat tgc gct gcc ctt gcc tcg aat ggc gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tac tct att gcc gat ggt ggc gtc gcc aaa tat aag aac tat atc gac   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc att cgt caa att gtc gtg gaa tat tcc gat atc cgg acc ctc ctg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gag cct gac tct ctt gcc aac ctg gtg acc aac ctc ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aag tgt gcc aat gct cag tca gcc tac ctt gag tgc atc aac tac   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcc gtc aca cag ctg aac ctt cca aat gtt gcg atg tat ttg gac gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggc cat gca gga tgg ctt ggc tgg ccg gca aac caa gac ccg gcc gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag cta ttt gca aat gtt tac aag aat gca tcg tct ccg aga gct ctt   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
cgc gga ttg gca acc aat gtc gcc aac tac aac ggg tgg aac att acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
agc ccc cca tcg tac acg caa ggc aac gct gtc tac aac gag aag ctg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tac atc cac gct att gga cct ctt ctt gcc aat cac ggc tgg tcc aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttc atc act gat caa ggt cga tcg gga aag cag cct acc gga   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag caa cag tgg gga gac tgg tgc aat gtg atc ggc acc gga ttt ggt   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att cgc cca tcc gca aac act ggg gac tcg ttg ctg gat tcg ttt gtc   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtc aag cca ggc ggc gag tgt gac ggc acc agc gac agc agt gcg   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cca cga ttt gac tcc cac tgt gcg ctc cca gat gcc ttg caa ccg gcg   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gct ggt gct tgg ttc caa gcc tac ttt gtg cag ctt ctc aca   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aac gca aac cca tcg ttc ctg taa                                   1416
Asn Ala Asn Pro Ser Phe Leu  *
465                 470
 

<210> 2
<211> 471
<212> PRT
<213> T. reesi

<400> 2
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 3
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 3
atg att gtt gga att ttg act aca ttg gca act cta gct aca ttg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt gca tct gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tca act tgt gtt tat tct aat gat tat tat tca caa tgt ttg cca gga   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gct tca tct tca tca tca act agg gct gca agt act aca tca agg   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tca cca act act tct aga tca tct tct gcc act ccg cca cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tca act act act aga gtt cca ccg gta ggt tct ggt act gct aca tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat cca ttt gta ggt gtt act cca tgg gct aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct tct gaa gtt tca tct ttg gct att cca tct ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gcc act gct gct gct gct gtt gca aag gtt cct tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act cta gat aaa act cca ttg atg gaa caa aca ttg gct gat ata   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aac ggt ggt aat tat gct ggt caa ttt gta gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg cca gat aga gat tgt gct gct ttg gct tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat ggt ggt gtt gct aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga caa att gtt gtt gaa tat tct gac att aga aca ttg tta   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt ata gaa cca gat tct ttg gct aat ttg gtt act aat tta ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gct aat gct caa tct gct tat ttg gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gta act caa tta aat ttg cct aat gtt gct atg tat ttg gat gca   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggt cac gca ggt tgg tta ggt tgg cca gct aat caa gat cca gca gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ttg ttt gct aat gtt tat aaa aat gct tct tct cct aga gct ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt tta gca act aat gta gct aat tat aat ggt tgg aat ata act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tca cca cca tct tat aca caa ggt aat gct gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att ggt cca ttg ttg gct aat cac ggt tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gct ttc ttt att act gat caa ggt aga tct gga aaa caa cca act ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag caa cag tgg ggt gat tgg tgt aat gta att ggt act ggt ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att aga cca tct gct aat act ggt gat tct ttg ttg gat tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca ggt ggt gaa tgt gat ggt act tct gat tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct aga ttt gat tct cat tgt gct ttg cca gat gca ttg cag cca gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca cag gcc ggt gca tgg ttt caa gca tat ttc gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gct aat cca tca ttt ttg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 4
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucelotide sequence
      modified for expression in S. cerevisiae

<400> 4
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 5
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1425)

<400> 5
tactcaagct t atg att gtt gga att ttg act aca ttg gca act cta gct  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
aca ttg gct gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg ggt caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gca tct gga tca act tgt gtt tat tct aat gat tat tat tca caa tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ttg cca gga gct gct tca tct tca tca tca act agg gct gca agt act   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
aca tca agg gtt tca cca act act tct aga tca tct tct gcc act ccg   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca ggt tca act act act aga gtt cca ccg gta ggt tct ggt act   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gct aca tat tct ggt aat cca ttt gta ggt gtt act cca tgg gct aat   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gct tat tat gct tct gaa gtt tca tct ttg gct att cca tct ttg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gcc act gct gct gct gct gtt gca aag gtt cct tct ttt   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ttg gat act cta gat aaa act cca ttg atg gaa caa aca ttg   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gct gat ata aga act gct aat aaa aac ggt ggt aat tat gct ggt caa   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gta gtt tat gat ttg cca gat aga gat tgt gct gct ttg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aat ggt gaa tat tct att gct gat ggt ggt gtt gct aaa tat aaa aat   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tat att gat act att aga caa att gtt gtt gaa tat tct gac att aga   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
aca ttg tta gtt ata gaa cca gat tct ttg gct aat ttg gtt act aat   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
tta ggt act cca aaa tgt gct aat gct caa tct gct tat ttg gaa tgt   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
att aat tat gct gta act caa tta aat ttg cct aat gtt gct atg tat   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ttg gat gca ggt cac gca ggt tgg tta ggt tgg cca gct aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
cca gca gct caa ttg ttt gct aat gtt tat aaa aat gct tct tct cct   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
aga gct ttg aga ggt tta gca act aat gta gct aat tat aat ggt tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aat ata act tca cca cca tct tat aca caa ggt aat gct gtt tat aat   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ttg tat att cat gct att ggt cca ttg ttg gct aat cac ggt   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aat gct ttc ttt att act gat caa ggt aga tct gga aaa caa   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
cca act ggt cag caa cag tgg ggt gat tgg tgt aat gta att ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
ggt ttc gga att aga cca tct gct aat act ggt gat tct ttg ttg gat   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gat ggt act tct gat   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct cct aga ttt gat tct cat tgt gct ttg cca gat gca ttg   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
cag cca gct cca cag gcc ggt gca tgg ttt caa gca tat ttc gtt caa   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ttg ttg act aat gct aat cca tca ttt ttg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 6
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 6
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 7
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (150)...(1427)

<400> 7
gaatactcca tatgatgatt gttggaattt tgactacatt ggcaactcta gctacattgg 60
ctgcttctgt tccattggaa gaaagacagg cttgttcttc tgtttggggt caatgtggtg 120
gtcaaaattg gtctggtcca acttgttgt gca tct gga tca act tgt gtt tat   173
                                Ala Ser Gly Ser Thr Cys Val Tyr
                                 1               5
 
tct aat gat tat tat tca caa tgt ttg cca gga gct gct tca tct tca   221
Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly Ala Ala Ser Ser Ser
     10                  15                  20
 
tca tca act agg gct gca agt act aca tca agg gtt tca cca act act   269
Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg Val Ser Pro Thr Thr
 25                  30                  35                  40
 
tct aga tca tct tct gcc act ccg cca cca ggt tca act act act aga   317
Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly Ser Thr Thr Thr Arg
                 45                  50                  55
 
gtt cca ccg gta ggt tct ggt act gct aca tat tct ggt aat cca ttt   365
Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr Ser Gly Asn Pro Phe
             60                  65                  70
 
gta ggt gtt act cca tgg gct aat gct tat tat gct tct gaa gtt tca   413
Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr Ala Ser Glu Val Ser
         75                  80                  85
 
tct ttg gct att cca tct ttg act ggt gct atg gcc act gct gct gct   461
Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met Ala Thr Ala Ala Ala
     90                  95                 100
 
gct gtt gca aag gtt cct tct ttt atg tgg ttg gat act cta gat aaa   509
Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu Asp Thr Leu Asp Lys
105                 110                 115                 120
 
act cca ttg atg gaa caa aca ttg gct gat ata aga act gct aat aaa   557
Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile Arg Thr Ala Asn Lys
                125                 130                 135
 
aac ggt ggt aat tat gct ggt caa ttt gta gtt tat gat ttg cca gat   605
Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val Tyr Asp Leu Pro Asp
            140                 145                 150
 
aga gat tgt gct gct ttg gct tct aat ggt gaa tat tct att gct gat   653
Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu Tyr Ser Ile Ala Asp
        155                 160                 165
 
ggt ggt gtt gct aaa tat aaa aat tat att gat act att aga caa att   701
Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp Thr Ile Arg Gln Ile
    170                 175                 180
 
gtt gtt gaa tat tct gac att aga aca ttg tta gtt ata gaa cca gat   749
Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu Val Ile Glu Pro Asp
185                 190                 195                 200
 
tct ttg gct aat ttg gtt act aat tta ggt act cca aaa tgt gct aat   797
Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr Pro Lys Cys Ala Asn
                205                 210                 215
 
gct caa tct gct tat ttg gaa tgt att aat tat gct gta act caa tta   845
Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr Ala Val Thr Gln Leu
            220                 225                 230
 
aat ttg cct aat gtt gct atg tat ttg gat gca ggt cac gca ggt tgg   893
Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala Gly His Ala Gly Trp
        235                 240                 245
 
tta ggt tgg cca gct aat caa gat cca gca gct caa ttg ttt gct aat   941
Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala Gln Leu Phe Ala Asn
    250                 255                 260
 
gtt tat aaa aat gct tct tct cct aga gct ttg aga ggt tta gca act   989
Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu Arg Gly Leu Ala Thr
265                 270                 275                 280
 
aat gta gct aat tat aat ggt tgg aat ata act tca cca cca tct tat   1037
Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr Ser Pro Pro Ser Tyr
                285                 290                 295
 
aca caa ggt aat gct gtt tat aat gaa aaa ttg tat att cat gct att   1085
Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu Tyr Ile His Ala Ile
            300                 305                 310
 
ggt cca ttg ttg gct aat cac ggt tgg tct aat gct ttc ttt att act   1133
Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn Ala Phe Phe Ile Thr
        315                 320                 325
 
gat caa ggt aga tct gga aaa caa cca act ggt cag caa cag tgg ggt   1181
Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly Gln Gln Gln Trp Gly
    330                 335                 340
 
gat tgg tgt aat gta att ggt act ggt ttc gga att aga cca tct gct   1229
Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly Ile Arg Pro Ser Ala
345                 350                 355                 360
 
aat act ggt gat tct ttg ttg gat tct ttc gtt tgg gtt aaa cca ggt   1277
Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val Trp Val Lys Pro Gly
                365                 370                 375
 
ggt gaa tgt gat ggt act tct gat tct tct gct cct aga ttt gat tct   1325
Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala Pro Arg Phe Asp Ser
            380                 385                 390
 
cat tgt gct ttg cca gat gca ttg cag cca gct cca cag gcc ggt gca   1373
His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala Pro Gln Ala Gly Ala
        395                 400                 405
 
tgg ttt caa gca tat ttc gtt caa ttg ttg act aat gct aat cca tca   1421
Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr Asn Ala Asn Pro Ser
    410                 415                 420
 
ttt ttg actagtcgat gcct                                           1441
Phe Leu
425
 

<210> 8
<211> 426
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 8
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
 1               5                  10                  15      
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
            20                  25                  30          
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
        35                  40                  45              
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
    50                  55                  60                  
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
65                  70                  75                  80  
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                85                  90                  95      
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            100                 105                 110         
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        115                 120                 125             
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    130                 135                 140                 
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
145                 150                 155                 160 
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                165                 170                 175     
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            180                 185                 190         
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        195                 200                 205             
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    210                 215                 220                 
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
225                 230                 235                 240 
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                245                 250                 255     
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            260                 265                 270         
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        275                 280                 285             
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    290                 295                 300                 
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
305                 310                 315                 320 
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                325                 330                 335     
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            340                 345                 350         
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        355                 360                 365             
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    370                 375                 380                 
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
385                 390                 395                 400 
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                405                 410                 415     
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            420                 425     


<210> 9
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 9
atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg gct acc ctg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc tgc gct tct ggt   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tcc acc tgc gtt tac tct aac gac tac tac tct cag tgt ctg cca ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gcg gcg tcc tct tct tct tct act cgt gcg gct tct acc acc tct cgt   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtg tct ccg acc acc tct cgt tct tct tct gct acc ccg cca cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act act cgc gtt cca ccg gtt ggt tct ggt act gcg acc tac   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg aat gcg tac tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct ttc atg tgg ctg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gac acc ctg gac aaa acc ccg ctg atg gaa cag acc ctc gcg gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc cag ttt gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tac gac ctc cca gac cgc gac tgc gct gct ctg gct tct aac ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa aac tac atc gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc atc cgt cag atc gtt gtt gaa tac tct gac atc cgt acc ctg ctg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc aac ctg ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa tgc atc aac tac   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg tac ctg gac gcg   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa gat ccg gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag ctg ttc gca aac gtt tac aaa aat gcg tct tct ccg cgt gcg ctc   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt tgg aac atc acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac aac gaa aaa ctg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gcg att ggt cca ctg ctg gct aat cac ggt tgg tct aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa cag ccg acc ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt act ggt ttc ggt   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc cgt ccg tct gcg aac act ggt gac tct ctg ctg gac tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct gac tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
ccg cgc ttc gac tct cac tgt gct ctg cca gac gct ctt caa ccg gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt cag ctg ctg acc   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gcg aac ccg tct ttc ctg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 10
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 10
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 11
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1425)

<400> 11
tactcaagct t atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg gct  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
acc ctg gct gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg ggt cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc tgc   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gct tct ggt tcc acc tgc gtt tac tct aac gac tac tac tct cag tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ctg cca ggc gcg gcg tcc tct tct tct tct act cgt gcg gct tct acc   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
acc tct cgt gtg tct ccg acc acc tct cgt tct tct tct gct acc ccg   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca ggt tct act act act cgc gtt cca ccg gtt ggt tct ggt act   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gcg acc tac tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg aat   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gcg tac tat gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct ttc   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ctg gac acc ctg gac aaa acc ccg ctg atg gaa cag acc ctc   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gcg gac att cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc cag   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gtt gtt tac gac ctc cca gac cgc gac tgc gct gct ctg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aac ggt gaa tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa aac   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tac atc gat acc atc cgt cag atc gtt gtt gaa tac tct gac atc cgt   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
acc ctg ctg gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc aac   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
ctg ggt act ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa tgc   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
atc aac tac gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg tac   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ctg gac gcg ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
ccg gct gct cag ctg ttc gca aac gtt tac aaa aat gcg tct tct ccg   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
cgt gcg ctc cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aac atc acc tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac aac   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ctg tat att cat gcg att ggt cca ctg ctg gct aat cac ggt   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aac gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa cag   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
ccg acc ggt caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
ggt ttc ggt atc cgt ccg tct gcg aac act ggt gac tct ctg ctg gac   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct gac   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct ccg cgc ttc gac tct cac tgt gct ctg cca gac gct ctt   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
caa ccg gct cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt cag   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ctg ctg acc aat gcg aac ccg tct ttc ctg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 12
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 12
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 13
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1427)

<400> 13
gaatactcca tatg atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg   50
                Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu
                 1               5                   10
 
gct acc ctg gct gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct   98
Ala Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser
         15                  20                  25
 
tct gtt tgg ggt cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc   146
Ser Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys
     30                  35                  40
 
tgc gct tct ggt tcc acc tgc gtt tac tct aac gac tac tac tct cag   194
Cys Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln
 45                  50                  55                  60
 
tgt ctg cca ggc gcg gcg tcc tct tct tct tct act cgt gcg gct tct   242
Cys Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser
                 65                  70                  75
 
acc acc tct cgt gtg tct ccg acc acc tct cgt tct tct tct gct acc   290
Thr Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr
             80                  85                  90
 
ccg cca cca ggt tct act act act cgc gtt cca ccg gtt ggt tct ggt   338
Pro Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly
         95                 100                 105
 
act gcg acc tac tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg   386
Thr Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala
    110                 115                 120
 
aat gcg tac tat gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg   434
Asn Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu
125                 130                 135                 140
 
act ggt gct atg gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct   482
Thr Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser
                145                 150                 155
 
ttc atg tgg ctg gac acc ctg gac aaa acc ccg ctg atg gaa cag acc   530
Phe Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr
            160                 165                 170
 
ctc gcg gac att cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc   578
Leu Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly
        175                 180                 185
 
cag ttt gtt gtt tac gac ctc cca gac cgc gac tgc gct gct ctg gct   626
Gln Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala
    190                 195                 200
 
tct aac ggt gaa tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa   674
Ser Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys
205                 210                 215                 220
 
aac tac atc gat acc atc cgt cag atc gtt gtt gaa tac tct gac atc   722
Asn Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile
                225                 230                 235
 
cgt acc ctg ctg gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc   770
Arg Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr
            240                 245                 250
 
aac ctg ggt act ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa   818
Asn Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu
        255                 260                 265
 
tgc atc aac tac gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg   866
Cys Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met
    270                 275                 280
 
tac ctg gac gcg ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa   914
Tyr Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln
285                 290                 295                 300
 
gat ccg gct gct cag ctg ttc gca aac gtt tac aaa aat gcg tct tct   962
Asp Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser
                305                 310                 315
 
ccg cgt gcg ctc cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt   1010
Pro Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly
            320                 325                 330
 
tgg aac atc acc tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac   1058
Trp Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr
        335                 340                 345
 
aac gaa aaa ctg tat att cat gcg att ggt cca ctg ctg gct aat cac   1106
Asn Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His
    350                 355                 360
 
ggt tgg tct aac gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa   1154
Gly Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys
365                 370                 375                 380
 
cag ccg acc ggt caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt   1202
Gln Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly
                385                 390                 395
 
act ggt ttc ggt atc cgt ccg tct gcg aac act ggt gac tct ctg ctg   1250
Thr Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu
            400                 405                 410
 
gac tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct   1298
Asp Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser
        415                 420                 425
 
gac tct tct gct ccg cgc ttc gac tct cac tgt gct ctg cca gac gct   1346
Asp Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala
    430                 435                 440
 
ctt caa ccg gct cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt   1394
Leu Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val
445                 450                 455                 460
 
cag ctg ctg acc aat gcg aac ccg tct ttc ctg actagtcgat gcct       1441
Gln Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
                465                 470
 

<210> 14
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 14
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 15
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 15
atg att gtt gga att ttg act act tta gct aca ttg gca act tta gca   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca tta gaa gag aga cag gct tgt tct tct gtt tgg gga   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt gga gga caa aat tgg tct gga cct aca tgt tgt gct tct gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tct act tgt gtt tat tca aat gat tat tat tct caa tgt ttg cca ggt   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca tct tct tct tct tca aca aga gct gct tca aca aca tca agg   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tca cct act act tct aga tca tct tca gct act cca cca cca gga   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tcg aca act act aga gtg cct ccc gtg gga tca gga aca gca act tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct gga aat cct ttt gtt gga gtg aca cca tgg gca aac gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct tct gaa gtt tct tca ttg gct att cct tca ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct acc gct gct gct gcc gtc gca aaa gtt cct tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act tta gat aaa act cca ttg atg gaa caa act tta gct gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aat gga gga aat tat gct gga caa ttt gtt gtg   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg cca gat aga gat tgt gct gct ttg gct tct aat gga gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat gga gga gtt gct aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga cag att gtt gtt gaa tat tct gat ata aga aca ttg tta   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gaa cca gat tca ttg gct aat ttg gtt act aat ttg gga aca   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cct aaa tgt gct aac gct caa tct gcc tat tta gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gtt act caa tta aat ttg cct aat gtg gct atg tat ttg gat gca   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cac gca gga tgg ttg gga tgg cca gca aat caa gat cca gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ttg ttt gca aat gtt tat aaa aac gct tct tca cct aga gct ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga gga ttg gct act aat gtt gct aat tat aat gga tgg aat ata act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cca cca tct tat act caa gga aat gca gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att gga cca ttg ttg gct aat cat ggc tgg tct aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gct ttc ttt att act gat caa ggt aga tct gga aaa caa cca act ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag cag cag tgg gga gat tgg tgt aat gtt att ggt act gga ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc aga cca tct gct aat act gga gat tca ttg ttg gat tct ttt gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct gat tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct aga ttt gat tct cat tgt gct tta cct gat gca tta cag cca gca   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gca aat cca tca ttt ttg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 16
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 16
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 17
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1425)

<400> 17
tactcaagct t atg att gtt gga att ttg act act tta gct aca ttg gca  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
act tta gca gct tct gtt cca tta gaa gag aga cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg gga caa tgt gga gga caa aat tgg tct gga cct aca tgt tgt   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gct tct gga tct act tgt gtt tat tca aat gat tat tat tct caa tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ttg cca ggt gct gca tct tct tct tct tca aca aga gct gct tca aca   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
aca tca agg gtt tca cct act act tct aga tca tct tca gct act cca   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca gga tcg aca act act aga gtg cct ccc gtg gga tca gga aca   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gca act tat tct gga aat cct ttt gtt gga gtg aca cca tgg gca aac   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gct tat tat gct tct gaa gtt tct tca ttg gct att cct tca ttg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gct acc gct gct gct gcc gtc gca aaa gtt cct tct ttt   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ttg gat act tta gat aaa act cca ttg atg gaa caa act tta   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gct gac att aga act gct aat aaa aat gga gga aat tat gct gga caa   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gtt gtg tat gat ttg cca gat aga gat tgt gct gct ttg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aat gga gaa tat tct att gct gat gga gga gtt gct aaa tat aaa aat   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tat att gat act att aga cag att gtt gtt gaa tat tct gat ata aga   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
aca ttg tta gtt att gaa cca gat tca ttg gct aat ttg gtt act aat   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
ttg gga aca cct aaa tgt gct aac gct caa tct gcc tat tta gaa tgt   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
att aat tat gct gtt act caa tta aat ttg cct aat gtg gct atg tat   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ttg gat gca gga cac gca gga tgg ttg gga tgg cca gca aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
cca gct gct caa ttg ttt gca aat gtt tat aaa aac gct tct tca cct   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
aga gct ttg aga gga ttg gct act aat gtt gct aat tat aat gga tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aat ata act tct cca cca tct tat act caa gga aat gca gtt tat aat   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ttg tat att cat gct att gga cca ttg ttg gct aat cat ggc   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aac gct ttc ttt att act gat caa ggt aga tct gga aaa caa   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
cca act ggt cag cag cag tgg gga gat tgg tgt aat gtt att ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
gga ttc gga atc aga cca tct gct aat act gga gat tca ttg ttg gat   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttt gtt tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct gat   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct cct aga ttt gat tct cat tgt gct tta cct gat gca tta   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
cag cca gca cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt caa   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ttg ttg act aat gca aat cca tca ttt ttg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 18
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 18
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 19
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1427)

<400> 19
gaatactcca tatg atg att gtt gga att ttg act act tta gct aca ttg   50
                Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu
                 1               5                   10
 
gca act tta gca gct tct gtt cca tta gaa gag aga cag gct tgt tct   98
Ala Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser
         15                  20                  25
 
tct gtt tgg gga caa tgt gga gga caa aat tgg tct gga cct aca tgt   146
Ser Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys
     30                  35                  40
 
tgt gct tct gga tct act tgt gtt tat tca aat gat tat tat tct caa   194
Cys Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln
 45                  50                  55                  60
 
tgt ttg cca ggt gct gca tct tct tct tct tca aca aga gct gct tca   242
Cys Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser
                 65                  70                  75
 
aca aca tca agg gtt tca cct act act tct aga tca tct tca gct act   290
Thr Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr
             80                  85                  90
 
cca cca cca gga tcg aca act act aga gtg cct ccc gtg gga tca gga   338
Pro Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly
         95                 100                 105
 
aca gca act tat tct gga aat cct ttt gtt gga gtg aca cca tgg gca   386
Thr Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala
    110                 115                 120
 
aac gct tat tat gct tct gaa gtt tct tca ttg gct att cct tca ttg   434
Asn Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu
125                 130                 135                 140
 
act ggt gct atg gct acc gct gct gct gcc gtc gca aaa gtt cct tct   482
Thr Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser
                145                 150                 155
 
ttt atg tgg ttg gat act tta gat aaa act cca ttg atg gaa caa act   530
Phe Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr
            160                 165                 170
 
tta gct gac att aga act gct aat aaa aat gga gga aat tat gct gga   578
Leu Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly
        175                 180                 185
 
caa ttt gtt gtg tat gat ttg cca gat aga gat tgt gct gct ttg gct   626
Gln Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala
    190                 195                 200
 
tct aat gga gaa tat tct att gct gat gga gga gtt gct aaa tat aaa   674
Ser Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys
205                 210                 215                 220
 
aat tat att gat act att aga cag att gtt gtt gaa tat tct gat ata   722
Asn Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile
                225                 230                 235
 
aga aca ttg tta gtt att gaa cca gat tca ttg gct aat ttg gtt act   770
Arg Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr
            240                 245                 250
 
aat ttg gga aca cct aaa tgt gct aac gct caa tct gcc tat tta gaa   818
Asn Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu
        255                 260                 265
 
tgt att aat tat gct gtt act caa tta aat ttg cct aat gtg gct atg   866
Cys Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met
    270                 275                 280
 
tat ttg gat gca gga cac gca gga tgg ttg gga tgg cca gca aat caa   914
Tyr Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln
285                 290                 295                 300
 
gat cca gct gct caa ttg ttt gca aat gtt tat aaa aac gct tct tca   962
Asp Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser
                305                 310                 315
 
cct aga gct ttg aga gga ttg gct act aat gtt gct aat tat aat gga   1010
Pro Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly
            320                 325                 330
 
tgg aat ata act tct cca cca tct tat act caa gga aat gca gtt tat   1058
Trp Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr
        335                 340                 345
 
aat gaa aaa ttg tat att cat gct att gga cca ttg ttg gct aat cat   1106
Asn Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His
    350                 355                 360
 
ggc tgg tct aac gct ttc ttt att act gat caa ggt aga tct gga aaa   1154
Gly Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys
365                 370                 375                 380
 
caa cca act ggt cag cag cag tgg gga gat tgg tgt aat gtt att ggt   1202
Gln Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly
                385                 390                 395
 
act gga ttc gga atc aga cca tct gct aat act gga gat tca ttg ttg   1250
Thr Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu
            400                 405                 410
 
gat tct ttt gtt tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct   1298
Asp Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser
        415                 420                 425
 
gat tct tct gct cct aga ttt gat tct cat tgt gct tta cct gat gca   1346
Asp Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala
    430                 435                 440
 
tta cag cca gca cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt   1394
Leu Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val
445                 450                 455                 460
 
caa ttg ttg act aat gca aat cca tca ttt ttg actagtcgat gcct       1441
Gln Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
                465                 470
 

<210> 20
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 20
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 21
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 21
atg att gtt ggt ata ttg act aca ttg gca act tta gct act tta gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt gct tct ggt   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tct act tgt gtt tat tct aat gat tat tat tct caa tgt ttg cca ggt   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca agc tct tct tca tct aca agg gct gca tca act aca agt aga   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tct cct act act tcc agg tct tct tct gct act cca cct cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act acc aga gtt cca cca gtt ggt tct gga act gct act tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat cca ttc gtt ggt gtt act cca tgg gca aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gca agc gaa gtt tct tct tta gct att cca tca ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct act gct gcg gct gct gtt gct aaa gtt cca tct ttc atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat aca ttg gac aaa act cca ttg atg gaa caa act tta gca gac atc   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aat ggt ggt aat tat gct ggt caa ttc gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg ccg gat aga gat tgt gca gct ttg gct tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat ggc gga gtg gcc aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga caa att gtt gtt gaa tat tct gac att aga aca ttg ttg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gaa cca gat tca tta gct aat ttg gtt act aat ttg gga act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gct aac gcc cag agt gct tac ttg gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gtt act caa tta aat ttg cca aat gtt gct atg tat tta gat gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cat gct gga tgg ttg ggt tgg cca gct aat caa gac ccg gca gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag tta ttc gct aat gtt tat aaa aat gct tct tca cca cgt gca ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt tta gcc aca aac gta gca aat tat aat ggt tgg aat att act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cct cca agc tat act caa ggt aat gct gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att ggt cca ttg ctt gct aat cat ggg tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttc att act gat caa ggt aga tct ggt aag caa cca aca gga   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa caa cag tgg ggt gat tgg tgt aat gtt att gga act ggt ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att aga cca tct gct aat act ggt gat tct tta ttg gat tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca gga gga gag tgt gat gga acg tcc gac tct tct gcg   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
ccg aga ttc gat tct cat tgt gct ttg cct gac gca ttg caa ccg gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca caa gcg gga gca tgg ttc cag gct tac ttc gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gct aat cct tca ttt tta                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 22
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 22
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 23
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 23
atg att gtt ggc att ttg acc acg ttg gcg acg tta gct acc ttg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct agc gtt ccg ttg gaa gaa cgt cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
cag tgt ggt ggt cag aat tgg tct ggt ccg acc tgt tgt gcc tct ggc   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tcc acc tgt gtt tat tct aat gat tat tat agc cag tgt ttg cct ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gcg tcg tct tct agc tct acg cgt gct gct tct acc acc tct cgt   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tct ccg acg acc tct cgc agt tct tct gcc acc cca cct cca gga   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct acg acc act aga gtc ccg ccc gtt ggt tct ggt aca gct acg tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat ccg ttt gtt ggt gtt acc ccg tgg gct aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct agt gag gtg tct tct ttg gcc att cct agc ttg aca ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct aca gcc gct gct gcc gtc gct aaa gtt ccg tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat acc ctt gac aaa acc cct tta atg gaa cag acc ctt gcc gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga acc gct aac aaa aat ggt ggt aat tat gct ggt cag ttt gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ctt cct gat cgt gat tgt gca gct ctt gcg tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gcc gac ggt ggc gtt gcc aaa tat aaa aat tat atc gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc att cgt cag att gtt gtc gaa tat tct gac att cgt act ctt ttg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtc att gaa ccg gat tct ttg gct aac cta gtt acg aac ttg gga acc   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gcg aat gcc cag tct gct tat ctg gag tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcc gtt acc cag ttg aat ttg ccg aat gta gcc atg tat ctt gac gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cat gct gga tgg tta ggt tgg ccc gct aat caa gac cct gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ctt ttt gct aat gtc tat aag aat gcc tct tct cct cgc gct ctt   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt ttg gct acg aat gtc gca aac tat aac ggt tgg aat att acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cct cct agt tat acc cag ggt aat gcc gtc tat aat gag aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gcc att ggt ccg ttg ttg gct aat cat ggt tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttt att acc gat cag ggt cgt tct ggt aaa caa cct acc ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa caa cag tgg ggc gac tgg tgt aat gtt ata ggt aca ggt ttt gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc cgt ccg agt gcc aac aca gga gat agc ttg ctt gac tct ttt gtc   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa ccg ggt ggt gag tgt gat ggc acc tct gat tct tct gca   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct cgg ttt gat tct cat tgt gcc ctt ccg gac gcc ctt cag cct gcg   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gcg ggt gcc tgg ttt caa gca tat ttc gtt cag ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aac gct aat ccg agc ttc ctt                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 24
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 24
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 25
<211> 1557
<212> DNA
<213> P. sanguineus

<220> 
<221> CDS            
<222> (1)...(1557)

<400> 25
atg ggc tcc ggt cta ttc agc ctc ttc gtc gcc atc gcg gcc atc tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
ggc agt ctc gct gcc atc ggg ccc aag gcg gac ctc gtc atc tcc gat   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gct gtt gtc aat ccc gat ggc acg cct cga gct gct gtt gtc gtg aat   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
ggt gac ttc cct gga cct ctc atc tct ggg aag aag ggg gat cac ttc   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
cag ctc aac gtg atc aac aag ttg acc aac cac acc atg ctg aag acg   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
acc agt ata cac tgg cac gga ctc ttc cag gaa cac act aac tgg gcc   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gac ggt ccc gca ttc gtc aat cag tgt ccc att gct tct gga cac tcc   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttc cta tac gac ttc cat gtg ccc gat caa gcc ggc acg tac tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cac agc cat ctg tcc acg cag tac tgc gac gga ttg cga gga ccg ctt   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gtc gtg tac gac ccc cac gat cct cag gcg cat ctg tat gat gtt gac   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aac gat gac act gtc att acc ttg gcg gat tgg tac cat gtc gcg gcc   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aag ctg ggc ccg caa ttc ccg agg ggc gcg aac tct acc ctc atc aac   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
ggc ctt gga cgc gcg gca acg gat agc act tcc gac ttg act gtc att   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
acc gtg gag cat ggg aag cgc tat cgt ttc agg ctt gtg tcg atc tct   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgt gac ccc aat cac acc ttc agc atc gat gga cac aac atg act atc   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
att gaa gtc gat ggc gtc aac agc aag ccc ctc acc gtc gac tcc atc   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
cag atc ttc gcc gct cag cgc tac tcc ttc gtg ttg aat gct aac caa   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
ccg gtg gac aac tac tgg att cgt gcg aat ccg agt ggc gga acc ctg   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
ggc ttc gag ggc ggg atc aac tct gtc atc ctc cgg tac aag ggt gcc   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
ccg gat gcc gaa ccc acc aac acg acg gca ccg aca tct gtg att cct   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
ctt gtg gag aca aat ttg cac cct ctc aag ccc atg caa gtg cct ggc   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
cga tct ggt gtt ggt aac gtc gat tat gcg aag acc ctc aat ttc aac   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttt aac ggc acc aac ttc ttc atc aac aat gcg acg ttc act ccg ccc   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
aca gtc ccc gtc ctc ctc cag atc ctg agc gga gcg cac aac gcg cag   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gac ctc ctg cct gca ggg tct gtt tac acc ctt cct ccg cac agc gcc   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
atc gag atc acc atg ccg gct acg acc atg gcc ccg ggc tca ccc cac   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
ccc ttc cac ttg cac ggc cac gtc ttc gct gtc gta cgc agc gcc ggc   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
agc tcc gag tac aac tac cac gac ccc atc ttc cgc gac gtc gtg agc   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggc cag ccc ggc gac agc gtc acg atc cgg ttc atg acg gac aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
ccg ggc ccg tgg ttc ctc cat tgc cac atc gac ttc cat ctc gag gcc   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
ggc ttc gcg atc gtg ttc gcg gag gac gtg aat gat atc aag tac gcg   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aac ccg gtc ccg ccg tcg tgg gag gag ctc tgc ccc atc tac gac aag   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
ctc ccg gag tcc gac cat tag                                       1557
Leu Pro Glu Ser Asp His  *
        515
 

<210> 26
<211> 518
<212> PRT
<213> P. sanguineus

<400> 26
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 27
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 27
atg ggt tct ggt ttg ttt tct ttg ttt gta gct att gct gct att tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
ggt tct ttg gct gct att ggt cct aag gct gat ttg gtt atc tca gac   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gct gtt gtt aat cca gat ggt act cca cgt gct gcc gta gtt gtt aat   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
ggt gat ttt cca ggt cca ttg att tca ggt aaa aag ggt gac cac ttt   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
caa tta aat gta att aat aaa ttg act aat cat act atg tta aaa act   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
act tct att cat tgg cat ggt ttg ttt caa gaa cat act aat tgg gct   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gac ggt ccc gct ttc gtt aat caa tgt cca att gct tct ggt cat tca   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttt ttg tat gat ttt cat gtt cca gat caa gca ggt act tat tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cat tct cat ttg tca act cag tat tgt gat ggt ttg aga ggt cca ttg   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gtt gtt tat gac cca cac gat cca caa gct cat tta tat gat gtt gat   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aat gat gat act gta att act cta gct gat tgg tat cat gtt gct gca   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aaa tta ggt cca caa ttt cca agg gga gct aat tct aca ttg att aat   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
ggt ttg ggt aga gct gct aca gat tca act tct gat ttg act gtt ata   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
act gtt gaa cat ggt aaa aga tat aga ttt aga ttg gtt tca att tca   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgt gat cca aat cat act ttt tct att gat gga cat aat atg act att   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
att gaa gtt gat ggt gtt aat tct aag cca ttg act gtt gat tct att   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
cag att ttt gct gct caa aga tat tca ttc gtt tta aat gca aat cag   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
cca gtt gat aat tat tgg ata aga gct aac cct tct ggt ggt act cta   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
ggt ttt gag ggt gga att aat tct gta att ttg aga tat aaa ggt gct   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
cca gat gct gaa cca act aat act act gct cca act tct gtt ata cca   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
ttg gtt gaa act aat tta cat cca tta aag cca atg caa gtt cca ggt   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
aga tca ggt gtt ggt aat gtt gat tat gct aaa act cta aat ttt aat   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttt aat ggt act aat ttc ttt att aat aat gca act ttt act cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
act gtt cct gtt ttg ttg caa att ttg tct ggt gct cat aat gct caa   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gat ttg tta ccc gct gga tct gtt tat aca ttg cca cca cat tct gct   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
att gaa att act atg cct gca act act atg gct cca ggt tct cct cat   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
cca ttt cat ttg cac ggt cat gtt ttt gct gtt gtt aga tct gct ggt   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gaa tat aat tat cat gat cca att ttt aga gat gtt gtt tca   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt cag cct ggc gat tct gtt aca att aga ttt atg act gat aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
cct ggt cca tgg ttt tta cat tgt cat att gat ttt cat ttg gaa gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
ggt ttt gct att gtt ttt gct gaa gat gtt aat gat ata aaa tat gct   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aat cca gtt ccg cca tct tgg gaa gag ttg tgt cca att tat gat aaa   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
tta cca gaa tct gat cat                                           1554
Leu Pro Glu Ser Asp His
        515
 

<210> 28
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 28
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 29
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 29
gaatactcca tatg atg ggt tct ggt ttg ttt tct ttg ttt gta gct att   50
                Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile
                 1               5                   10
 
gct gct att tct ggt tct ttg gct gct att ggt cct aag gct gat ttg   98
Ala Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu
         15                  20                  25
 
gtt atc tca gac gct gtt gtt aat cca gat ggt act cca cgt gct gcc   146
Val Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala
     30                  35                  40
 
gta gtt gtt aat ggt gat ttt cca ggt cca ttg att tca ggt aaa aag   194
Val Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys
 45                  50                  55                  60
 
ggt gac cac ttt caa tta aat gta att aat aaa ttg act aat cat act   242
Gly Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr
                 65                  70                  75
 
atg tta aaa act act tct att cat tgg cat ggt ttg ttt caa gaa cat   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His
             80                  85                  90
 
act aat tgg gct gac ggt ccc gct ttc gtt aat caa tgt cca att gct   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
         95                 100                 105
 
tct ggt cat tca ttt ttg tat gat ttt cat gtt cca gat caa gca ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly
    110                 115                 120
 
act tat tgg tat cat tct cat ttg tca act cag tat tgt gat ggt ttg   434
Thr Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
125                 130                 135                 140
 
aga ggt cca ttg gtt gtt tat gac cca cac gat cca caa gct cat tta   482
Arg Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu
                145                 150                 155
 
tat gat gtt gat aat gat gat act gta att act cta gct gat tgg tat   530
Tyr Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
            160                 165                 170
 
cat gtt gct gca aaa tta ggt cca caa ttt cca agg gga gct aat tct   578
His Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser
        175                 180                 185
 
aca ttg att aat ggt ttg ggt aga gct gct aca gat tca act tct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp
    190                 195                 200
 
ttg act gtt ata act gtt gaa cat ggt aaa aga tat aga ttt aga ttg   674
Leu Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu
205                 210                 215                 220
 
gtt tca att tca tgt gat cca aat cat act ttt tct att gat gga cat   722
Val Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
                225                 230                 235
 
aat atg act att att gaa gtt gat ggt gtt aat tct aag cca ttg act   770
Asn Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr
            240                 245                 250
 
gtt gat tct att cag att ttt gct gct caa aga tat tca ttc gtt tta   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
        255                 260                 265
 
aat gca aat cag cca gtt gat aat tat tgg ata aga gct aac cct tct   866
Asn Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
    270                 275                 280
 
ggt ggt act cta ggt ttt gag ggt gga att aat tct gta att ttg aga   914
Gly Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg
285                 290                 295                 300
 
tat aaa ggt gct cca gat gct gaa cca act aat act act gct cca act   962
Tyr Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr
                305                 310                 315
 
tct gtt ata cca ttg gtt gaa act aat tta cat cca tta aag cca atg   1010
Ser Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met
            320                 325                 330
 
caa gtt cca ggt aga tca ggt gtt ggt aat gtt gat tat gct aaa act   1058
Gln Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr
        335                 340                 345
 
cta aat ttt aat ttt aat ggt act aat ttc ttt att aat aat gca act   1106
Leu Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr
    350                 355                 360
 
ttt act cca cca act gtt cct gtt ttg ttg caa att ttg tct ggt gct   1154
Phe Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cat aat gct caa gat ttg tta ccc gct gga tct gtt tat aca ttg cca   1202
His Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro
                385                 390                 395
 
cca cat tct gct att gaa att act atg cct gca act act atg gct cca   1250
Pro His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro
            400                 405                 410
 
ggt tct cct cat cca ttt cat ttg cac ggt cat gtt ttt gct gtt gtt   1298
Gly Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val
        415                 420                 425
 
aga tct gct ggt tct tct gaa tat aat tat cat gat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tca act ggt cag cct ggc gat tct gtt aca att aga ttt   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe
445                 450                 455                 460
 
atg act gat aat cct ggt cca tgg ttt tta cat tgt cat att gat ttt   1442
Met Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat ttg gaa gct ggt ttt gct att gtt ttt gct gaa gat gtt aat gat   1490
His Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp
            480                 485                 490
 
ata aaa tat gct aat cca gtt ccg cca tct tgg gaa gag ttg tgt cca   1538
Ile Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro
        495                 500                 505
 
att tat gat aaa tta cca gaa tct gat cat actagtcagt gcct           1582
Ile Tyr Asp Lys Leu Pro Glu Ser Asp His
    510                 515
 

<210> 30
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 30
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 31
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 31
tactcaagct t atg ggt tct ggt ttg ttt tct ttg ttt gta gct att gct  50
             Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala
              1               5                   10
 
gct att tct ggt tct ttg gct gct att ggt cct aag gct gat ttg gtt   98
Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val
     15                  20                  25
 
atc tca gac gct gtt gtt aat cca gat ggt act cca cgt gct gcc gta   146
Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val
 30                  35                  40                  45
 
gtt gtt aat ggt gat ttt cca ggt cca ttg att tca ggt aaa aag ggt   194
Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly
                 50                  55                  60
 
gac cac ttt caa tta aat gta att aat aaa ttg act aat cat act atg   242
Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met
             65                  70                  75
 
tta aaa act act tct att cat tgg cat ggt ttg ttt caa gaa cat act   290
Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr
         80                  85                  90
 
aat tgg gct gac ggt ccc gct ttc gtt aat caa tgt cca att gct tct   338
Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser
     95                 100                 105
 
ggt cat tca ttt ttg tat gat ttt cat gtt cca gat caa gca ggt act   386
Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr
110                 115                 120                 125
 
tat tgg tat cat tct cat ttg tca act cag tat tgt gat ggt ttg aga   434
Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg
                130                 135                 140
 
ggt cca ttg gtt gtt tat gac cca cac gat cca caa gct cat tta tat   482
Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr
            145                 150                 155
 
gat gtt gat aat gat gat act gta att act cta gct gat tgg tat cat   530
Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His
        160                 165                 170
 
gtt gct gca aaa tta ggt cca caa ttt cca agg gga gct aat tct aca   578
Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr
    175                 180                 185
 
ttg att aat ggt ttg ggt aga gct gct aca gat tca act tct gat ttg   626
Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu
190                 195                 200                 205
 
act gtt ata act gtt gaa cat ggt aaa aga tat aga ttt aga ttg gtt   674
Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val
                210                 215                 220
 
tca att tca tgt gat cca aat cat act ttt tct att gat gga cat aat   722
Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn
            225                 230                 235
 
atg act att att gaa gtt gat ggt gtt aat tct aag cca ttg act gtt   770
Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val
        240                 245                 250
 
gat tct att cag att ttt gct gct caa aga tat tca ttc gtt tta aat   818
Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn
    255                 260                 265
 
gca aat cag cca gtt gat aat tat tgg ata aga gct aac cct tct ggt   866
Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly
270                 275                 280                 285
 
ggt act cta ggt ttt gag ggt gga att aat tct gta att ttg aga tat   914
Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr
                290                 295                 300
 
aaa ggt gct cca gat gct gaa cca act aat act act gct cca act tct   962
Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser
            305                 310                 315
 
gtt ata cca ttg gtt gaa act aat tta cat cca tta aag cca atg caa   1010
Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln
        320                 325                 330
 
gtt cca ggt aga tca ggt gtt ggt aat gtt gat tat gct aaa act cta   1058
Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu
    335                 340                 345
 
aat ttt aat ttt aat ggt act aat ttc ttt att aat aat gca act ttt   1106
Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe
350                 355                 360                 365
 
act cca cca act gtt cct gtt ttg ttg caa att ttg tct ggt gct cat   1154
Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His
                370                 375                 380
 
aat gct caa gat ttg tta ccc gct gga tct gtt tat aca ttg cca cca   1202
Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro
            385                 390                 395
 
cat tct gct att gaa att act atg cct gca act act atg gct cca ggt   1250
His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly
        400                 405                 410
 
tct cct cat cca ttt cat ttg cac ggt cat gtt ttt gct gtt gtt aga   1298
Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg
    415                 420                 425
 
tct gct ggt tct tct gaa tat aat tat cat gat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tca act ggt cag cct ggc gat tct gtt aca att aga ttt atg   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met
                450                 455                 460
 
act gat aat cct ggt cca tgg ttt tta cat tgt cat att gat ttt cat   1442
Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ttg gaa gct ggt ttt gct att gtt ttt gct gaa gat gtt aat gat ata   1490
Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile
        480                 485                 490
 
aaa tat gct aat cca gtt ccg cca tct tgg gaa gag ttg tgt cca att   1538
Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile
    495                 500                 505
 
tat gat aaa tta cca gaa tct gat cat gaattccgat g                  1576
Tyr Asp Lys Leu Pro Glu Ser Asp His
510                 515
 

<210> 32
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 32
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 33
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 33
atg ggt tct ggt ctg ttc tct ctg ttc gtt gct atc gcg gct atc tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
ggt tct ctg gct gca att ggt ccg aaa gca gac ctg gtt atc tct gac   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gcg gtt gtt aac ccg gac ggt act cca cgc gct gct gtt gtt gtt aac   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
ggt gac ttc cca ggc ccg ctg atc tcc ggt aaa aag ggt gac cac ttc   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
caa ctg aac gtt atc aac aaa ctg acc aac cac acc atg ctg aaa acc   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
acc tct atc cat tgg cac ggt ctg ttt cag gaa cac acc aat tgg gcg   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gac ggt cca gcg ttc gtt aac caa tgc ccg atc gcg tct ggt cac tct   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttc ctg tac gac ttc cat gtt cca gat cag gct ggc acc tat tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cac tct cac ctg tct acc cag tac tgc gat ggt ctc cgt ggt ccg ctc   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gtt gtt tac gac ccg cat gac ccg caa gcg cac ctg tat gac gtt gac   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aat gac gac acc gtt atc acc ctg gct gat tgg tat cac gtt gcg gcg   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aaa ctg ggt cca cag ttc cca cgc ggt gct aat tct acc ctc atc aac   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
ggt ctg ggt cgt gcg gct acc gac tct acc tct gac ctg acc gtt att   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
act gtt gaa cac ggc aag cgt tat cgt ttt cgt ctg gtt agc atc tct   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgc gac ccg aac cac acc ttc tct atc gat ggt cac aac atg act atc   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
atc gaa gtt gac ggt gtt aac tct aaa ccg ctg acc gtt gac tct atc   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
cag atc ttc gcg gct caa cgt tac tct ttc gtt ctg aac gcg aac cag   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
cca gtt gac aac tat tgg att cgt gcg aac ccg tcc ggt ggt act ctg   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
ggt ttc gaa ggt ggt atc aac tct gtt atc ctg cgt tac aaa ggt gct   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
cca gat gcg gaa ccg acc aac act acc gcg ccg acc tct gtt atc cca   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
ctg gtt gaa act aac ctc cac cca ctg aaa cca atg cag gtt cca ggt   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
cgt tct ggt gtt ggt aac gtt gac tac gcg aaa acc ctg aac ttc aac   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttc aac ggt act aac ttc ttc atc aac aac gcg acc ttc acc ccg cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
act gtt ccg gtg ctg ctc caa atc ctg tct ggt gcg cat aat gct cag   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gac ctg ttg ccg gcg ggc tct gtt tac acc ctg cct cca cat tct gcg   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
atc gaa atc act atg cca gcg acc acc atg gct cca ggc tcc ccg cac   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
ccg ttc cac ctg cac ggt cac gtt ttc gcg gtt gtt cgc tct gct ggc   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tcc tcc gaa tac aac tac cac gac ccg atc ttt cgt gac gtt gtt agc   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt cag cct ggt gat tct gtt acc atc cgt ttc atg acc gac aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttt cac ctg gag gcg   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
ggt ttc gcg atc gtt ttt gcg gaa gac gtt aac gac atc aaa tat gcg   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aac cca gtg ccg ccg tct tgg gaa gaa ctg tgc ccg atc tac gac aaa   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
ctg ccg gaa tct gac cac                                           1554
Leu Pro Glu Ser Asp His
        515
 

<210> 34
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 34
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 35
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 35
gaatactcca tatg atg ggt tct ggt ctg ttc tct ctg ttc gtt gct atc   50
                Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile
                 1               5                   10
 
gcg gct atc tct ggt tct ctg gct gca att ggt ccg aaa gca gac ctg   98
Ala Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu
         15                  20                  25
 
gtt atc tct gac gcg gtt gtt aac ccg gac ggt act cca cgc gct gct   146
Val Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala
     30                  35                  40
 
gtt gtt gtt aac ggt gac ttc cca ggc ccg ctg atc tcc ggt aaa aag   194
Val Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys
 45                  50                  55                  60
 
ggt gac cac ttc caa ctg aac gtt atc aac aaa ctg acc aac cac acc   242
Gly Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr
                 65                  70                  75
 
atg ctg aaa acc acc tct atc cat tgg cac ggt ctg ttt cag gaa cac   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His
             80                  85                  90
 
acc aat tgg gcg gac ggt cca gcg ttc gtt aac caa tgc ccg atc gcg   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
         95                 100                 105
 
tct ggt cac tct ttc ctg tac gac ttc cat gtt cca gat cag gct ggc   386
Ser Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly
    110                 115                 120
 
acc tat tgg tat cac tct cac ctg tct acc cag tac tgc gat ggt ctc   434
Thr Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
125                 130                 135                 140
 
cgt ggt ccg ctc gtt gtt tac gac ccg cat gac ccg caa gcg cac ctg   482
Arg Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu
                145                 150                 155
 
tat gac gtt gac aat gac gac acc gtt atc acc ctg gct gat tgg tat   530
Tyr Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
            160                 165                 170
 
cac gtt gcg gcg aaa ctg ggt cca cag ttc cca cgc ggt gct aat tct   578
His Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser
        175                 180                 185
 
acc ctc atc aac ggt ctg ggt cgt gcg gct acc gac tct acc tct gac   626
Thr Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp
    190                 195                 200
 
ctg acc gtt att act gtt gaa cac ggc aag cgt tat cgt ttt cgt ctg   674
Leu Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu
205                 210                 215                 220
 
gtt agc atc tct tgc gac ccg aac cac acc ttc tct atc gat ggt cac   722
Val Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
                225                 230                 235
 
aac atg act atc atc gaa gtt gac ggt gtt aac tct aaa ccg ctg acc   770
Asn Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr
            240                 245                 250
 
gtt gac tct atc cag atc ttc gcg gct caa cgt tac tct ttc gtt ctg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
        255                 260                 265
 
aac gcg aac cag cca gtt gac aac tat tgg att cgt gcg aac ccg tcc   866
Asn Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
    270                 275                 280
 
ggt ggt act ctg ggt ttc gaa ggt ggt atc aac tct gtt atc ctg cgt   914
Gly Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg
285                 290                 295                 300
 
tac aaa ggt gct cca gat gcg gaa ccg acc aac act acc gcg ccg acc   962
Tyr Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr
                305                 310                 315
 
tct gtt atc cca ctg gtt gaa act aac ctc cac cca ctg aaa cca atg   1010
Ser Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met
            320                 325                 330
 
cag gtt cca ggt cgt tct ggt gtt ggt aac gtt gac tac gcg aaa acc   1058
Gln Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr
        335                 340                 345
 
ctg aac ttc aac ttc aac ggt act aac ttc ttc atc aac aac gcg acc   1106
Leu Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr
    350                 355                 360
 
ttc acc ccg cca act gtt ccg gtg ctg ctc caa atc ctg tct ggt gcg   1154
Phe Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cat aat gct cag gac ctg ttg ccg gcg ggc tct gtt tac acc ctg cct   1202
His Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro
                385                 390                 395
 
cca cat tct gcg atc gaa atc act atg cca gcg acc acc atg gct cca   1250
Pro His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro
            400                 405                 410
 
ggc tcc ccg cac ccg ttc cac ctg cac ggt cac gtt ttc gcg gtt gtt   1298
Gly Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val
        415                 420                 425
 
cgc tct gct ggc tcc tcc gaa tac aac tac cac gac ccg atc ttt cgt   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg
    430                 435                 440
 
gac gtt gtt agc act ggt cag cct ggt gat tct gtt acc atc cgt ttc   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe
445                 450                 455                 460
 
atg acc gac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttt   1442
Met Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cac ctg gag gcg ggt ttc gcg atc gtt ttt gcg gaa gac gtt aac gac   1490
His Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp
            480                 485                 490
 
atc aaa tat gcg aac cca gtg ccg ccg tct tgg gaa gaa ctg tgc ccg   1538
Ile Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro
        495                 500                 505
 
atc tac gac aaa ctg ccg gaa tct gac cac actagtcagt gcct           1582
Ile Tyr Asp Lys Leu Pro Glu Ser Asp His
    510                 515
 

<210> 36
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 36
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 37
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 37
tactcaagct t atg ggt tct ggt ctg ttc tct ctg ttc gtt gct atc gcg  50
             Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala
              1               5                   10
 
gct atc tct ggt tct ctg gct gca att ggt ccg aaa gca gac ctg gtt   98
Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val
     15                  20                  25
 
atc tct gac gcg gtt gtt aac ccg gac ggt act cca cgc gct gct gtt   146
Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val
 30                  35                  40                  45
 
gtt gtt aac ggt gac ttc cca ggc ccg ctg atc tcc ggt aaa aag ggt   194
Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly
                 50                  55                  60
 
gac cac ttc caa ctg aac gtt atc aac aaa ctg acc aac cac acc atg   242
Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met
             65                  70                  75
 
ctg aaa acc acc tct atc cat tgg cac ggt ctg ttt cag gaa cac acc   290
Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr
         80                  85                  90
 
aat tgg gcg gac ggt cca gcg ttc gtt aac caa tgc ccg atc gcg tct   338
Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser
     95                 100                 105
 
ggt cac tct ttc ctg tac gac ttc cat gtt cca gat cag gct ggc acc   386
Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr
110                 115                 120                 125
 
tat tgg tat cac tct cac ctg tct acc cag tac tgc gat ggt ctc cgt   434
Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg
                130                 135                 140
 
ggt ccg ctc gtt gtt tac gac ccg cat gac ccg caa gcg cac ctg tat   482
Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr
            145                 150                 155
 
gac gtt gac aat gac gac acc gtt atc acc ctg gct gat tgg tat cac   530
Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His
        160                 165                 170
 
gtt gcg gcg aaa ctg ggt cca cag ttc cca cgc ggt gct aat tct acc   578
Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr
    175                 180                 185
 
ctc atc aac ggt ctg ggt cgt gcg gct acc gac tct acc tct gac ctg   626
Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu
190                 195                 200                 205
 
acc gtt att act gtt gaa cac ggc aag cgt tat cgt ttt cgt ctg gtt   674
Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val
                210                 215                 220
 
agc atc tct tgc gac ccg aac cac acc ttc tct atc gat ggt cac aac   722
Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn
            225                 230                 235
 
atg act atc atc gaa gtt gac ggt gtt aac tct aaa ccg ctg acc gtt   770
Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val
        240                 245                 250
 
gac tct atc cag atc ttc gcg gct caa cgt tac tct ttc gtt ctg aac   818
Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn
    255                 260                 265
 
gcg aac cag cca gtt gac aac tat tgg att cgt gcg aac ccg tcc ggt   866
Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly
270                 275                 280                 285
 
ggt act ctg ggt ttc gaa ggt ggt atc aac tct gtt atc ctg cgt tac   914
Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr
                290                 295                 300
 
aaa ggt gct cca gat gcg gaa ccg acc aac act acc gcg ccg acc tct   962
Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser
            305                 310                 315
 
gtt atc cca ctg gtt gaa act aac ctc cac cca ctg aaa cca atg cag   1010
Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln
        320                 325                 330
 
gtt cca ggt cgt tct ggt gtt ggt aac gtt gac tac gcg aaa acc ctg   1058
Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu
    335                 340                 345
 
aac ttc aac ttc aac ggt act aac ttc ttc atc aac aac gcg acc ttc   1106
Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe
350                 355                 360                 365
 
acc ccg cca act gtt ccg gtg ctg ctc caa atc ctg tct ggt gcg cat   1154
Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His
                370                 375                 380
 
aat gct cag gac ctg ttg ccg gcg ggc tct gtt tac acc ctg cct cca   1202
Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro
            385                 390                 395
 
cat tct gcg atc gaa atc act atg cca gcg acc acc atg gct cca ggc   1250
His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly
        400                 405                 410
 
tcc ccg cac ccg ttc cac ctg cac ggt cac gtt ttc gcg gtt gtt cgc   1298
Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg
    415                 420                 425
 
tct gct ggc tcc tcc gaa tac aac tac cac gac ccg atc ttt cgt gac   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt agc act ggt cag cct ggt gat tct gtt acc atc cgt ttc atg   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met
                450                 455                 460
 
acc gac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttt cac   1442
Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ctg gag gcg ggt ttc gcg atc gtt ttt gcg gaa gac gtt aac gac atc   1490
Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile
        480                 485                 490
 
aaa tat gcg aac cca gtg ccg ccg tct tgg gaa gaa ctg tgc ccg atc   1538
Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile
    495                 500                 505
 
tac gac aaa ctg ccg gaa tct gac cac gaattccgat g                  1576
Tyr Asp Lys Leu Pro Glu Ser Asp His
510                 515
 

<210> 38
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 38
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 39
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 39
atg gga tct ggt ttg ttt tca ttg ttt gtt gct att gct gct att tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
gga tca ttg gct gct att gga cct aag gct gat ttg gtt att tca gat   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gct gtt gtt aat cca gat ggt act cct aga gct gcc gtg gtt gtt aat   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
gga gat ttt cct ggt cct ttg att tct ggt aaa aag gga gat cac ttt   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
caa tta aat gtt att aat aaa ttg act aat cat act atg tta aaa act   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
act tct att cat tgg cat gga ttg ttt caa gaa cat act aat tgg gct   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gac ggt cct gct ttt gtt aat cag tgt cca att gca tct ggt cat tca   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttt ttg tat gat ttt cat gtt cct gat caa gct ggt act tat tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cat tct cat ttg tct act caa tat tgt gat gga tta aga gga cca ttg   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gtt gtt tat gat cca cat gac cca caa gca cat tta tat gat gtt gat   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aat gat gat act gtg att aca tta gct gat tgg tat cat gtt gct gca   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aag ttg gga cca caa ttt cca agg gga gct aat tct act tta att aat   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
gga ttg ggt aga gct gct act gat tct act tct gat ttg act gtt att   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
act gtt gaa cat gga aaa aga tat aga ttt aga ttg gtt tct att tct   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgt gat cca aat cat act ttt tct att gat gga cat aat atg act att   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
att gaa gtt gat gga gtt aat tct aaa cct ttg act gtt gat tct att   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
caa att ttc gct gct caa aga tat tct ttt gtt tta aac gct aat cag   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
cca gtt gat aat tat tgg atc aga gct aat cca tca gga ggt act tta   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
gga ttt gag gga gga att aat tct gtt att ttg aga tat aaa ggt gct   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
cca gat gct gaa cca act aat act act gct cca act tct gtt att cca   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
ttg gtt gaa act aat tta cat cca tta aag cca atg caa gtt cca ggt   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
aga tcc gga gtt gga aat gtt gat tat gct aaa act tta aat ttt aat   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttt aat gga aca aat ttc ttt att aat aat gca act ttt act cca cct   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
act gtt cct gtg ttg ttg caa att ttg tct ggt gct cat aac gct caa   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gat ttg tta cct gct gga tca gtt tat act tta cca cca cat tct gct   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
att gaa att act atg cct gct act act atg gct cca gga tct cca cat   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
cca ttt cat ttg cat gga cat gtt ttc gct gtt gtg aga tct gcc ggt   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tca gaa tat aat tat cat gat cca att ttt aga gat gtt gtt tca   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acg ggt caa cca gga gat tct gtt aca att aga ttt atg act gat aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat tta gaa gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
gga ttc gct att gtg ttc gct gaa gac gtt aat gac att aaa tat gct   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aat cct gtt cct cct agt tgg gaa gaa tta tgt cca att tat gat aag   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
ttg cca gaa tct gat cat                                           1554
Leu Pro Glu Ser Asp His
        515
 

<210> 40
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 40
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 41
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 41
gaatactcca tatg atg gga tct ggt ttg ttt tca ttg ttt gtt gct att   50
                Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile
                 1               5                   10
 
gct gct att tct gga tca ttg gct gct att gga cct aag gct gat ttg   98
Ala Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu
         15                  20                  25
 
gtt att tca gat gct gtt gtt aat cca gat ggt act cct aga gct gcc   146
Val Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala
     30                  35                  40
 
gtg gtt gtt aat gga gat ttt cct ggt cct ttg att tct ggt aaa aag   194
Val Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys
 45                  50                  55                  60
 
gga gat cac ttt caa tta aat gtt att aat aaa ttg act aat cat act   242
Gly Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr
                 65                  70                  75
 
atg tta aaa act act tct att cat tgg cat gga ttg ttt caa gaa cat   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His
             80                  85                  90
 
act aat tgg gct gac ggt cct gct ttt gtt aat cag tgt cca att gca   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
         95                 100                 105
 
tct ggt cat tca ttt ttg tat gat ttt cat gtt cct gat caa gct ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly
    110                 115                 120
 
act tat tgg tat cat tct cat ttg tct act caa tat tgt gat gga tta   434
Thr Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
125                 130                 135                 140
 
aga gga cca ttg gtt gtt tat gat cca cat gac cca caa gca cat tta   482
Arg Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu
                145                 150                 155
 
tat gat gtt gat aat gat gat act gtg att aca tta gct gat tgg tat   530
Tyr Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
            160                 165                 170
 
cat gtt gct gca aag ttg gga cca caa ttt cca agg gga gct aat tct   578
His Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser
        175                 180                 185
 
act tta att aat gga ttg ggt aga gct gct act gat tct act tct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp
    190                 195                 200
 
ttg act gtt att act gtt gaa cat gga aaa aga tat aga ttt aga ttg   674
Leu Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu
205                 210                 215                 220
 
gtt tct att tct tgt gat cca aat cat act ttt tct att gat gga cat   722
Val Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
                225                 230                 235
 
aat atg act att att gaa gtt gat gga gtt aat tct aaa cct ttg act   770
Asn Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr
            240                 245                 250
 
gtt gat tct att caa att ttc gct gct caa aga tat tct ttt gtt tta   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
        255                 260                 265
 
aac gct aat cag cca gtt gat aat tat tgg atc aga gct aat cca tca   866
Asn Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
    270                 275                 280
 
gga ggt act tta gga ttt gag gga gga att aat tct gtt att ttg aga   914
Gly Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg
285                 290                 295                 300
 
tat aaa ggt gct cca gat gct gaa cca act aat act act gct cca act   962
Tyr Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr
                305                 310                 315
 
tct gtt att cca ttg gtt gaa act aat tta cat cca tta aag cca atg   1010
Ser Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met
            320                 325                 330
 
caa gtt cca ggt aga tcc gga gtt gga aat gtt gat tat gct aaa act   1058
Gln Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr
        335                 340                 345
 
tta aat ttt aat ttt aat gga aca aat ttc ttt att aat aat gca act   1106
Leu Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr
    350                 355                 360
 
ttt act cca cct act gtt cct gtg ttg ttg caa att ttg tct ggt gct   1154
Phe Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cat aac gct caa gat ttg tta cct gct gga tca gtt tat act tta cca   1202
His Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro
                385                 390                 395
 
cca cat tct gct att gaa att act atg cct gct act act atg gct cca   1250
Pro His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro
            400                 405                 410
 
gga tct cca cat cca ttt cat ttg cat gga cat gtt ttc gct gtt gtg   1298
Gly Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val
        415                 420                 425
 
aga tct gcc ggt tct tca gaa tat aat tat cat gat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tca acg ggt caa cca gga gat tct gtt aca att aga ttt   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe
445                 450                 455                 460
 
atg act gat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt   1442
Met Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat tta gaa gct gga ttc gct att gtg ttc gct gaa gac gtt aat gac   1490
His Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp
            480                 485                 490
 
att aaa tat gct aat cct gtt cct cct agt tgg gaa gaa tta tgt cca   1538
Ile Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro
        495                 500                 505
 
att tat gat aag ttg cca gaa tct gat cat actagtcagt gcct           1582
Ile Tyr Asp Lys Leu Pro Glu Ser Asp His
    510                 515
 

<210> 42
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 42
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 43
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 43
tactcaagct t atg gga tct ggt ttg ttt tca ttg ttt gtt gct att gct  50
             Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala
              1               5                   10
 
gct att tct gga tca ttg gct gct att gga cct aag gct gat ttg gtt   98
Ala Ile Ser Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val
     15                  20                  25
 
att tca gat gct gtt gtt aat cca gat ggt act cct aga gct gcc gtg   146
Ile Ser Asp Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val
 30                  35                  40                  45
 
gtt gtt aat gga gat ttt cct ggt cct ttg att tct ggt aaa aag gga   194
Val Val Asn Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly
                 50                  55                  60
 
gat cac ttt caa tta aat gtt att aat aaa ttg act aat cat act atg   242
Asp His Phe Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met
             65                  70                  75
 
tta aaa act act tct att cat tgg cat gga ttg ttt caa gaa cat act   290
Leu Lys Thr Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr
         80                  85                  90
 
aat tgg gct gac ggt cct gct ttt gtt aat cag tgt cca att gca tct   338
Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser
     95                 100                 105
 
ggt cat tca ttt ttg tat gat ttt cat gtt cct gat caa gct ggt act   386
Gly His Ser Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr
110                 115                 120                 125
 
tat tgg tat cat tct cat ttg tct act caa tat tgt gat gga tta aga   434
Tyr Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg
                130                 135                 140
 
gga cca ttg gtt gtt tat gat cca cat gac cca caa gca cat tta tat   482
Gly Pro Leu Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr
            145                 150                 155
 
gat gtt gat aat gat gat act gtg att aca tta gct gat tgg tat cat   530
Asp Val Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His
        160                 165                 170
 
gtt gct gca aag ttg gga cca caa ttt cca agg gga gct aat tct act   578
Val Ala Ala Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr
    175                 180                 185
 
tta att aat gga ttg ggt aga gct gct act gat tct act tct gat ttg   626
Leu Ile Asn Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu
190                 195                 200                 205
 
act gtt att act gtt gaa cat gga aaa aga tat aga ttt aga ttg gtt   674
Thr Val Ile Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val
                210                 215                 220
 
tct att tct tgt gat cca aat cat act ttt tct att gat gga cat aat   722
Ser Ile Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn
            225                 230                 235
 
atg act att att gaa gtt gat gga gtt aat tct aaa cct ttg act gtt   770
Met Thr Ile Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val
        240                 245                 250
 
gat tct att caa att ttc gct gct caa aga tat tct ttt gtt tta aac   818
Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn
    255                 260                 265
 
gct aat cag cca gtt gat aat tat tgg atc aga gct aat cca tca gga   866
Ala Asn Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly
270                 275                 280                 285
 
ggt act tta gga ttt gag gga gga att aat tct gtt att ttg aga tat   914
Gly Thr Leu Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr
                290                 295                 300
 
aaa ggt gct cca gat gct gaa cca act aat act act gct cca act tct   962
Lys Gly Ala Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser
            305                 310                 315
 
gtt att cca ttg gtt gaa act aat tta cat cca tta aag cca atg caa   1010
Val Ile Pro Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln
        320                 325                 330
 
gtt cca ggt aga tcc gga gtt gga aat gtt gat tat gct aaa act tta   1058
Val Pro Gly Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu
    335                 340                 345
 
aat ttt aat ttt aat gga aca aat ttc ttt att aat aat gca act ttt   1106
Asn Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe
350                 355                 360                 365
 
act cca cct act gtt cct gtg ttg ttg caa att ttg tct ggt gct cat   1154
Thr Pro Pro Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His
                370                 375                 380
 
aac gct caa gat ttg tta cct gct gga tca gtt tat act tta cca cca   1202
Asn Ala Gln Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro
            385                 390                 395
 
cat tct gct att gaa att act atg cct gct act act atg gct cca gga   1250
His Ser Ala Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly
        400                 405                 410
 
tct cca cat cca ttt cat ttg cat gga cat gtt ttc gct gtt gtg aga   1298
Ser Pro His Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg
    415                 420                 425
 
tct gcc ggt tct tca gaa tat aat tat cat gat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tca acg ggt caa cca gga gat tct gtt aca att aga ttt atg   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met
                450                 455                 460
 
act gat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat   1442
Thr Asp Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
tta gaa gct gga ttc gct att gtg ttc gct gaa gac gtt aat gac att   1490
Leu Glu Ala Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile
        480                 485                 490
 
aaa tat gct aat cct gtt cct cct agt tgg gaa gaa tta tgt cca att   1538
Lys Tyr Ala Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile
    495                 500                 505
 
tat gat aag ttg cca gaa tct gat cat gaattccgat g                  1576
Tyr Asp Lys Leu Pro Glu Ser Asp His
510                 515
 

<210> 44
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 44
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 45
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 45
atg ggt tct ggt ttg ttc tca ttg ttc gtt gct att gct gct att tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
ggt tca ttg gct gct att ggt cca aag gcc gat ttg gtt att tct gat   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gct gtt gtt aat cca gac ggt aca cct aga gct gct gta gtg gtt aat   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
ggt gat ttt cct ggt cca ttg att tct ggc aaa aag ggt gat cat ttt   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
cag ctc aat gtt att aat aaa ttg act aat cat act atg tta aag act   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
act tct att cac tgg cat ggt tta ttt caa gaa cat act aat tgg gct   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gac gga cca gca ttc gtt aat caa tgt cca att gct tct ggt cat tct   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttc ttg tat gat ttt cat gtt cca gat caa gca gga act tat tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cat tct cat ttg tct act caa tat tgt gat ggt ttg aga ggt cct tta   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gtt gtt tat gat cca cat gat cct caa gct cat tta tat gat gtt gat   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aat gat gat act gtt atc act tta gct gat tgg tat cac gta gct gcc   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aaa ttg ggt cca caa ttc cct aga gga gca aat tct act tta att aat   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
ggt ttg ggt agg gcc gct act gat tcc aca tca gat ttg act gtt att   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
act gtt gaa cat gga aaa aga tat aga ttc aga ttg gtt tct att tct   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgt gat cca aat cat act ttc tct att gat ggt cat aat atg act att   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
att gaa gtt gat ggt gtt aat tct aaa cca ttg act gta gat tct att   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
cag att ttc gct gct caa aga tat tct ttc gtt tta aat gct aat caa   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
cca gtt gat aat tat tgg att aga gct aac cca tct ggt gga act tta   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
ggt ttc gaa ggt ggt ata aat tct gtt att ttg aga tat aaa gga gcc   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
cct gac gca gaa cca act aat act act gct cca act tct gtt att cca   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
tta gta gaa act aat ttg cat cca tta aaa cca atg caa gta cct gga   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
cgt agt gga gtt gga aat gtt gat tat gct aaa act tta aac ttc aat   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttc aat ggt aca aat ttc ttc att aat aat gct act ttc act cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
act gtt ccg gta ttg ttg caa att ttg tct gga gcg cat aat gca caa   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gat ttg cta cct gct ggc tct gtt tat aca tta ccg cca cat tct gca   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
att gaa att act atg cct gct acc act atg gca cct gga agt cct cat   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
cca ttt cac cta cac ggt cat gtg ttc gct gtg gtt aga tca gct ggt   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
agt agt gaa tat aat tat cac gat cca att ttc aga gat gtt gtt tct   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt caa cct ggt gac agt gta act att aga ttc atg act gat aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
ccg ggt cct tgg ttc tta cat tgt cat att gat ttc cac ttg gaa gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
gga ttc gct atc gtt ttc gcc gaa gat gtt aat gac att aaa tac gct   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aat cct gtg cct cca tct tgg gaa gaa ttg tgt cca atc tat gac aaa   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
ttg cct gag tct gat cat                                           1554
Leu Pro Glu Ser Asp His
        515
 

<210> 46
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 46
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 47
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 47
atg ggt tct ggt ttg ttt tct ttg ttt gtt gcc att gcc gcc att tct   48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                   10                  15
 
ggt tct ttg gct gcc att ggt ccg aaa gcc gat ttg gtt atc tct gac   96
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
             20                  25                  30
 
gcc gtt gtt aat ccg gat ggt aca cct cgt gct gct gtt gtg gtg aat   144
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
         35                  40                  45
 
ggt gat ttt cca ggt ccg ttg att tct ggt aag aaa ggt gat cat ttt   192
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
     50                  55                  60
 
cag ttg aat gtt ata aat aaa ttg acg aat cat acc atg ttg aaa acc   240
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
 65                  70                  75                  80
 
acc tct att cat tgg cat ggt ttg ttc caa gaa cat act aac tgg gcc   288
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                 85                  90                  95
 
gat ggt cct gcg ttt gtt aat cag tgt ccg att gcc tct ggt cat tct   336
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110
 
ttc ttg tat gat ttt cat gtt ccg gat cag gct gga aca tat tgg tat   384
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125
 
cat tct cat ttg tct acc cag tat tgt gat ggt ttg cgt ggt ccg cta   432
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140
 
gta gtt tat gat ccg cat gat ccc cag gcc cat tta tat gat gtt gat   480
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160
 
aat gat gat acc gtt atc acc ttg gct gac tgg tat cat gta gcc gcg   528
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175
 
aaa ttg ggt ccc cag ttt ccg aga gga gcg aac tct acc ttg att aat   576
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190
 
ggt ttg ggt cga gca gca aca gat tct acc tct gat ttg acc gtc att   624
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205
 
acc gtt gaa cat ggt aaa cgt tat cgt ttt cgt ttg gtt tct att tct   672
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220
 
tgt gat ccg aat cat aca ttt tct att gat ggt cat aat atg acg att   720
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240
 
att gaa gtt gat ggt gtt aat tct aaa ccg tta aca gta gat agc att   768
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255
 
cag att ttt gca gcg caa cgg tat tct ttt gtt ttg aat gcc aac cag   816
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270
 
cca gtt gat aat tat tgg att cgt gct aat ccg tct ggt ggt acg ttg   864
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285
 
ggt ttt gaa ggt ggc att aat tct gtc att ttg cgt tat aaa ggt gct   912
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300
 
cct gat gca gag ccg acg aat acc acc gct ccg acc tct gtt atc ccg   960
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320
 
ttg gtc gaa acc aac ttg cat ccg ctt aaa cca atg cag gtc cct ggc   1008
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335
 
aga tct ggt gtt ggt aat gtt gat tat gcc aaa acc ttg aat ttt aat   1056
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350
 
ttt aat ggc act aac ttc ttc atc aac aat gct acg ttt acg cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365
 
aca gta ccg gtt ttg ctt cag att ttg tct gga gcc cat aat gcc cag   1152
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380
 
gat ttg cta cct gct ggc tct gtt tat acc ttg cct cct cat tct gcc   1200
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400
 
atc gaa att aca atg ccc gct aca act atg gct ccg gga tct cct cat   1248
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415
 
cct ttt cat ctt cat gga cat gtt ttt gcc gta gtg cgt tct gcg gga   1296
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
agt tct gaa tat aat tat cat gat ccg att ttt cgt gat gtt gtt tct   1344
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt cag ccg ggc gac tct gtt acc att cgt ttt atg acc gat aat   1392
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460
 
cct ggt cct tgg ttt ttg cat tgt cat att gat ttt cat ttg gaa gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480
 
ggg ttt gcc ata gtc ttt gcg gaa gat gtt aat gat atc aaa tat gct   1488
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495
 
aat ccc gtt cct ccg tct tgg gaa gaa ttg tgt cca atc tat gat aaa   1536
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510
 
ttg ccg gaa tcc gat cat                                           1554
Leu Pro Glu Ser Asp His
        515
 

<210> 48
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 48
Met Gly Ser Gly Leu Phe Ser Leu Phe Val Ala Ile Ala Ala Ile Ser
 1               5                  10                  15      
Gly Ser Leu Ala Ala Ile Gly Pro Lys Ala Asp Leu Val Ile Ser Asp
            20                  25                  30          
Ala Val Val Asn Pro Asp Gly Thr Pro Arg Ala Ala Val Val Val Asn
        35                  40                  45              
Gly Asp Phe Pro Gly Pro Leu Ile Ser Gly Lys Lys Gly Asp His Phe
    50                  55                  60                  
Gln Leu Asn Val Ile Asn Lys Leu Thr Asn His Thr Met Leu Lys Thr
65                  70                  75                  80  
Thr Ser Ile His Trp His Gly Leu Phe Gln Glu His Thr Asn Trp Ala
                85                  90                  95      
Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His Ser
            100                 105                 110         
Phe Leu Tyr Asp Phe His Val Pro Asp Gln Ala Gly Thr Tyr Trp Tyr
        115                 120                 125             
His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro Leu
    130                 135                 140                 
Val Val Tyr Asp Pro His Asp Pro Gln Ala His Leu Tyr Asp Val Asp
145                 150                 155                 160 
Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala Ala
                165                 170                 175     
Lys Leu Gly Pro Gln Phe Pro Arg Gly Ala Asn Ser Thr Leu Ile Asn
            180                 185                 190         
Gly Leu Gly Arg Ala Ala Thr Asp Ser Thr Ser Asp Leu Thr Val Ile
        195                 200                 205             
Thr Val Glu His Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Ile Ser
    210                 215                 220                 
Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Asn Met Thr Ile
225                 230                 235                 240 
Ile Glu Val Asp Gly Val Asn Ser Lys Pro Leu Thr Val Asp Ser Ile
                245                 250                 255     
Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asn Ala Asn Gln
            260                 265                 270         
Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Gly Gly Thr Leu
        275                 280                 285             
Gly Phe Glu Gly Gly Ile Asn Ser Val Ile Leu Arg Tyr Lys Gly Ala
    290                 295                 300                 
Pro Asp Ala Glu Pro Thr Asn Thr Thr Ala Pro Thr Ser Val Ile Pro
305                 310                 315                 320 
Leu Val Glu Thr Asn Leu His Pro Leu Lys Pro Met Gln Val Pro Gly
                325                 330                 335     
Arg Ser Gly Val Gly Asn Val Asp Tyr Ala Lys Thr Leu Asn Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asn Ala Thr Phe Thr Pro Pro
        355                 360                 365             
Thr Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala His Asn Ala Gln
    370                 375                 380                 
Asp Leu Leu Pro Ala Gly Ser Val Tyr Thr Leu Pro Pro His Ser Ala
385                 390                 395                 400 
Ile Glu Ile Thr Met Pro Ala Thr Thr Met Ala Pro Gly Ser Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Val Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr His Asp Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Ser Val Thr Ile Arg Phe Met Thr Asp Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Glu Ala
465                 470                 475                 480 
Gly Phe Ala Ile Val Phe Ala Glu Asp Val Asn Asp Ile Lys Tyr Ala
                485                 490                 495     
Asn Pro Val Pro Pro Ser Trp Glu Glu Leu Cys Pro Ile Tyr Asp Lys
            500                 505                 510         
Leu Pro Glu Ser Asp His
        515             


<210> 49
<211> 1119
<212> DNA
<213> T. versicolor

<220> 
<221> CDS            
<222> (1)...(1119)

<400> 49
atg gct ttc aag tct ctt ctt tct ttt gtc tcg gtc att gga gcg ctc   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
cag ggc gcg aac gcc gcg ttg acc cgc cgc gtc gct tgc ccc gac ggc   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtg aac acc gct acc aac gcg gcg tgc tgc caa ctc ttc gct gtc cgc   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gag gac ctc cag cag aac ctg ttc cac ggc ggt ctc tgc acg gct gag   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gcg cac gag tct ctc cgt ctg acc ttc cac gac gcc atc gcc atc tcc   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
ccc gct ctc gag gcc cag ggc atc ttc ggt ggt ggt ggt gcc gac ggc   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tcc atc gcg atc ttc ccc gag atc gag aca aac ttc cac ccc aac att   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
ggt ctc gac gaa atc atc gag ctc cag aag ccg ttc atc gcc cgt cac   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aac atc tcc gtt gct gac ttc att caa ttc gct ggt gcc atc ggt gcc   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
tcg aac tgc gcg ggt gct ccc cag ctc gct gcc ttc gtc ggc cgc aag   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gac gcc acc cag ccc gcc ccc gac ggc ctc gtc ccc gag ccg ttc cac   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
acg ccc gac cag atc ttc gac cgt ctc gcg gac gcg tct cag ggc gag   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttc gac ccc atc ctg acg gtc tgg ctc ctg acc gcg cac acc gtt gct   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gcc gcc aac gac gtc gac ccc acc aag tcc ggc ctg ccg ttc gac tcc   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
acc ccc gag ctc tgg gac acg cag ttc ttc ctc gag acc cag ctc cgc   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
ggc acg agc ttc ccc ggc tcc ggc ggc aac cag ggc gag gtc gag tct   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
ccc ctt gcg ggc gag atg cgt ctc cag tcc gac cac acc atc gct cgc   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gac tcc cgc acg gca tgc gag tgg cag tcg ttc gtc gac aac cag ccg   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aag gct cag cag atg ttc cag ttc gtg ttc cac gac ctt tcc atc ttc   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
ggc cag gac atc aac acg ctc gtc gac tgc act gaa gtc gtc ccc atc   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
ccg gct gac cct cag ggc cac acg cac ttc ccc gct ggc ctg agc aac   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gcc gac atc gag cag gct tgt gcc gag acc ccc ttc ccg acc ttc ccc   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
acc gac ccc gga ccc aag acc gcc gtc gcc ccc gtc ccc aag ccc cct   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gcc gcc cgg aag taa                                               1119
Ala Ala Arg Lys  *
    370
 

<210> 50
<211> 372
<212> PRT
<213> T. versicolor

<400> 50
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 51
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1116)

<400> 51
atg gca ttt aaa tct ttg ttg tct ttt gta tct gta att ggt gct ttg   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
caa ggt gct aat gcc gca ttg act agg aga gtt gct tgt cca gat ggt   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtt aat act gct aca aat gct gct tgt tgt caa ttg ttt gct gtt aga   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gaa gat ttg caa caa aat tta ttt cat ggt ggt ttg tgt act gct gaa   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gct cat gaa tct ttg aga ttg act ttt cat gat gct att gct att tca   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
cca gct ttg gag gct caa gga att ttt gga ggt ggt gga gct gat ggt   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tct ata gct att ttt cca gaa att gaa act aat ttt cac cct aat ata   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
ggt ttg gat gaa att att gaa ttg caa aaa cca ttt att gct aga cat   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aat ata tct gtt gct gat ttt ata caa ttc gct ggt gct att ggt gct   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
tct aat tgt gcc ggg gct cct cag ttg gca gct ttt gta ggt aga aaa   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gat gca act caa cca gct cca gat ggt cta gtt cca gaa cca ttt cat   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
act cca gat caa att ttc gat aga ttg gct gat gct tca caa gga gaa   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttt gat cca att ttg act gtt tgg ttg ttg act gct cat act gtt gct   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gct gcc aat gat gtt gat cca act aaa tct ggt ttg cca ttt gat tca   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
act cct gaa ttg tgg gat act caa ttc ttt ttg gaa act cag ttg aga   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
ggt act tct ttt cca ggt tct ggt ggt aat caa ggt gaa gta gaa tct   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
cct ttg gct ggt gaa atg agg ttg caa tct gat cat act att gct aga   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gat tct aga act gct tgt gaa tgg caa tct ttt gta gat aat caa cct   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aaa gct caa caa atg ttt caa ttc gtt ttt cat gat ttg tct att ttt   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
gga caa gat ata aat act cta gtt gat tgt act gaa gta gtt cct ata   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
cca gct gac cca caa gga cat act cat ttt cca gcc ggt ttg tct aat   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gct gat ata gaa cag gct tgt gct gaa act cca ttt cca act ttt cca   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
act gat cca ggt cca aaa aca gca gta gca cca gta cct aag cca cca   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gca gct aga aaa                                                   1116
Ala Ala Arg Lys
    370
 

<210> 52
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 52
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 53
<211> 1138
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1127)

<400> 53
tactcaagct t atg gca ttt aaa tct ttg ttg tct ttt gta tct gta att  50
             Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile
              1               5                   10
 
ggt gct ttg caa ggt gct aat gcc gca ttg act agg aga gtt gct tgt   98
Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys
     15                  20                  25
 
cca gat ggt gtt aat act gct aca aat gct gct tgt tgt caa ttg ttt   146
Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe
 30                  35                  40                  45
 
gct gtt aga gaa gat ttg caa caa aat tta ttt cat ggt ggt ttg tgt   194
Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys
                 50                  55                  60
 
act gct gaa gct cat gaa tct ttg aga ttg act ttt cat gat gct att   242
Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
             65                  70                  75
 
gct att tca cca gct ttg gag gct caa gga att ttt gga ggt ggt gga   290
Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly
         80                  85                  90
 
gct gat ggt tct ata gct att ttt cca gaa att gaa act aat ttt cac   338
Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His
     95                 100                 105
 
cct aat ata ggt ttg gat gaa att att gaa ttg caa aaa cca ttt att   386
Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile
110                 115                 120                 125
 
gct aga cat aat ata tct gtt gct gat ttt ata caa ttc gct ggt gct   434
Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala
                130                 135                 140
 
att ggt gct tct aat tgt gcc ggg gct cct cag ttg gca gct ttt gta   482
Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val
            145                 150                 155
 
ggt aga aaa gat gca act caa cca gct cca gat ggt cta gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu
        160                 165                 170
 
cca ttt cat act cca gat caa att ttc gat aga ttg gct gat gct tca   578
Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser
    175                 180                 185
 
caa gga gaa ttt gat cca att ttg act gtt tgg ttg ttg act gct cat   626
Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His
190                 195                 200                 205
 
act gtt gct gct gcc aat gat gtt gat cca act aaa tct ggt ttg cca   674
Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro
                210                 215                 220
 
ttt gat tca act cct gaa ttg tgg gat act caa ttc ttt ttg gaa act   722
Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr
            225                 230                 235
 
cag ttg aga ggt act tct ttt cca ggt tct ggt ggt aat caa ggt gaa   770
Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu
        240                 245                 250
 
gta gaa tct cct ttg gct ggt gaa atg agg ttg caa tct gat cat act   818
Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr
    255                 260                 265
 
att gct aga gat tct aga act gct tgt gaa tgg caa tct ttt gta gat   866
Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp
270                 275                 280                 285
 
aat caa cct aaa gct caa caa atg ttt caa ttc gtt ttt cat gat ttg   914
Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu
                290                 295                 300
 
tct att ttt gga caa gat ata aat act cta gtt gat tgt act gaa gta   962
Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val
            305                 310                 315
 
gtt cct ata cca gct gac cca caa gga cat act cat ttt cca gcc ggt   1010
Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly
        320                 325                 330
 
ttg tct aat gct gat ata gaa cag gct tgt gct gaa act cca ttt cca   1058
Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro
    335                 340                 345
 
act ttt cca act gat cca ggt cca aaa aca gca gta gca cca gta cct   1106
Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro
350                 355                 360                 365
 
aag cca cca gca gct aga aaa gaattccgat g                          1138
Lys Pro Pro Ala Ala Arg Lys
                370
 

<210> 54
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 54
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 55
<211> 1144
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1130)

<400> 55
gaatactcca tatg atg gca ttt aaa tct ttg ttg tct ttt gta tct gta   50
                Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val
                 1               5                   10
 
att ggt gct ttg caa ggt gct aat gcc gca ttg act agg aga gtt gct   98
Ile Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala
         15                  20                  25
 
tgt cca gat ggt gtt aat act gct aca aat gct gct tgt tgt caa ttg   146
Cys Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu
     30                  35                  40
 
ttt gct gtt aga gaa gat ttg caa caa aat tta ttt cat ggt ggt ttg   194
Phe Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu
 45                  50                  55                  60
 
tgt act gct gaa gct cat gaa tct ttg aga ttg act ttt cat gat gct   242
Cys Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala
                 65                  70                  75
 
att gct att tca cca gct ttg gag gct caa gga att ttt gga ggt ggt   290
Ile Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly
             80                  85                  90
 
gga gct gat ggt tct ata gct att ttt cca gaa att gaa act aat ttt   338
Gly Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe
         95                 100                 105
 
cac cct aat ata ggt ttg gat gaa att att gaa ttg caa aaa cca ttt   386
His Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe
    110                 115                 120
 
att gct aga cat aat ata tct gtt gct gat ttt ata caa ttc gct ggt   434
Ile Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly
125                 130                 135                 140
 
gct att ggt gct tct aat tgt gcc ggg gct cct cag ttg gca gct ttt   482
Ala Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe
                145                 150                 155
 
gta ggt aga aaa gat gca act caa cca gct cca gat ggt cta gtt cca   530
Val Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro
            160                 165                 170
 
gaa cca ttt cat act cca gat caa att ttc gat aga ttg gct gat gct   578
Glu Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala
        175                 180                 185
 
tca caa gga gaa ttt gat cca att ttg act gtt tgg ttg ttg act gct   626
Ser Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala
    190                 195                 200
 
cat act gtt gct gct gcc aat gat gtt gat cca act aaa tct ggt ttg   674
His Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu
205                 210                 215                 220
 
cca ttt gat tca act cct gaa ttg tgg gat act caa ttc ttt ttg gaa   722
Pro Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu
                225                 230                 235
 
act cag ttg aga ggt act tct ttt cca ggt tct ggt ggt aat caa ggt   770
Thr Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly
            240                 245                 250
 
gaa gta gaa tct cct ttg gct ggt gaa atg agg ttg caa tct gat cat   818
Glu Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His
        255                 260                 265
 
act att gct aga gat tct aga act gct tgt gaa tgg caa tct ttt gta   866
Thr Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val
    270                 275                 280
 
gat aat caa cct aaa gct caa caa atg ttt caa ttc gtt ttt cat gat   914
Asp Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp
285                 290                 295                 300
 
ttg tct att ttt gga caa gat ata aat act cta gtt gat tgt act gaa   962
Leu Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu
                305                 310                 315
 
gta gtt cct ata cca gct gac cca caa gga cat act cat ttt cca gcc   1010
Val Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala
            320                 325                 330
 
ggt ttg tct aat gct gat ata gaa cag gct tgt gct gaa act cca ttt   1058
Gly Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe
        335                 340                 345
 
cca act ttt cca act gat cca ggt cca aaa aca gca gta gca cca gta   1106
Pro Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val
    350                 355                 360
 
cct aag cca cca gca gct aga aaa actagtcagt gcct                   1144
Pro Lys Pro Pro Ala Ala Arg Lys
365                 370
 

<210> 56
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 56
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 57
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1116)

<400> 57
atg gct ttc aaa tct ctg ctg tct ttc gtt tcg gtt atc ggt gcg ctc   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
cag ggt gcg aac gct gct ctg acc cgt cgt gtt gcg tgc ccg gac ggt   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtt aat acc gcg acc aat gct gct tgt tgc cag ctg ttc gcg gtt cgt   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gaa gac ctc cag cag aac ctg ttc cac ggt ggt ctg tgc act gcg gag   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gct cac gaa tct ctc cgt ctg acc ttt cac gac gcg att gcg atc tct   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
cca gcg ttg gaa gct cag ggt atc ttc ggt ggt ggt ggc gct gat ggt   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tct atc gcg atc ttc cca gaa atc gaa acc aac ttc cac ccg aac atc   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
ggt ctg gac gaa atc atc gaa ctc cag aaa ccg ttc atc gct cgt cac   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aac atc tcc gtt gct gat ttc atc cag ttc gcg ggt gct atc ggt gcg   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
tct aac tgt gcg ggt gcg cca caa ctg gct gct ttc gtt ggt cgt aaa   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gac gcg act cag cca gct ccg gat ggt ctg gtt cca gaa ccg ttc cac   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
acc ccg gac cag atc ttt gat cgt ttg gcg gac gcg tct cag ggt gag   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttc gat ccg att ctg acc gtt tgg ctg ctg acc gcg cac acc gtt gct   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gct gcg aac gac gtt gac ccg acc aaa tct ggt ctg ccg ttc gac tct   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
acc ccg gaa ctg tgg gac acc cag ttc ttc ttg gaa act cag ctg cgt   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
ggt act tct ttc cca ggc tct ggt ggt aac caa ggt gaa gtt gaa tct   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
ccg ctg gct ggt gaa atg cgt ctc cag tct gac cac acc atc gct cgt   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gat tct cgt acc gcg tgc gaa tgg cag tct ttc gtt gac aac cag ccg   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aaa gct cag cag atg ttc caa ttc gtg ttc cat gac ctg tct atc ttc   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
ggt cag gac atc aac acc ctg gtt gac tgc act gaa gtt gtt ccg att   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
ccg gct gat ccg cag ggc cac acc cat ttc cca gcg ggt ctc agc aac   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gcg gac atc gaa cag gct tgc gca gaa acc ccg ttc cca acc ttt ccg   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
acc gac cca ggt ccg aaa acc gct gtt gct cca gtt cca aaa cct ccg   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gca gca cgt aaa                                                   1116
Ala Ala Arg Lys
    370
 

<210> 58
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 58
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 59
<211> 1138
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1127)

<400> 59
tactcaagct t atg gct ttc aaa tct ctg ctg tct ttc gtt tcg gtt atc  50
             Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile
              1               5                   10
 
ggt gcg ctc cag ggt gcg aac gct gct ctg acc cgt cgt gtt gcg tgc   98
Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys
     15                  20                  25
 
ccg gac ggt gtt aat acc gcg acc aat gct gct tgt tgc cag ctg ttc   146
Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe
 30                  35                  40                  45
 
gcg gtt cgt gaa gac ctc cag cag aac ctg ttc cac ggt ggt ctg tgc   194
Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys
                 50                  55                  60
 
act gcg gag gct cac gaa tct ctc cgt ctg acc ttt cac gac gcg att   242
Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
             65                  70                  75
 
gcg atc tct cca gcg ttg gaa gct cag ggt atc ttc ggt ggt ggt ggc   290
Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly
         80                  85                  90
 
gct gat ggt tct atc gcg atc ttc cca gaa atc gaa acc aac ttc cac   338
Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His
     95                 100                 105
 
ccg aac atc ggt ctg gac gaa atc atc gaa ctc cag aaa ccg ttc atc   386
Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile
110                 115                 120                 125
 
gct cgt cac aac atc tcc gtt gct gat ttc atc cag ttc gcg ggt gct   434
Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala
                130                 135                 140
 
atc ggt gcg tct aac tgt gcg ggt gcg cca caa ctg gct gct ttc gtt   482
Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val
            145                 150                 155
 
ggt cgt aaa gac gcg act cag cca gct ccg gat ggt ctg gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu
        160                 165                 170
 
ccg ttc cac acc ccg gac cag atc ttt gat cgt ttg gcg gac gcg tct   578
Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser
    175                 180                 185
 
cag ggt gag ttc gat ccg att ctg acc gtt tgg ctg ctg acc gcg cac   626
Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His
190                 195                 200                 205
 
acc gtt gct gct gcg aac gac gtt gac ccg acc aaa tct ggt ctg ccg   674
Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro
                210                 215                 220
 
ttc gac tct acc ccg gaa ctg tgg gac acc cag ttc ttc ttg gaa act   722
Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr
            225                 230                 235
 
cag ctg cgt ggt act tct ttc cca ggc tct ggt ggt aac caa ggt gaa   770
Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu
        240                 245                 250
 
gtt gaa tct ccg ctg gct ggt gaa atg cgt ctc cag tct gac cac acc   818
Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr
    255                 260                 265
 
atc gct cgt gat tct cgt acc gcg tgc gaa tgg cag tct ttc gtt gac   866
Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp
270                 275                 280                 285
 
aac cag ccg aaa gct cag cag atg ttc caa ttc gtg ttc cat gac ctg   914
Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu
                290                 295                 300
 
tct atc ttc ggt cag gac atc aac acc ctg gtt gac tgc act gaa gtt   962
Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val
            305                 310                 315
 
gtt ccg att ccg gct gat ccg cag ggc cac acc cat ttc cca gcg ggt   1010
Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly
        320                 325                 330
 
ctc agc aac gcg gac atc gaa cag gct tgc gca gaa acc ccg ttc cca   1058
Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro
    335                 340                 345
 
acc ttt ccg acc gac cca ggt ccg aaa acc gct gtt gct cca gtt cca   1106
Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro
350                 355                 360                 365
 
aaa cct ccg gca gca cgt aaa gaattccgat g                          1138
Lys Pro Pro Ala Ala Arg Lys
                370
 

<210> 60
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 60
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 61
<211> 1144
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1130)

<400> 61
gaatactcca tatg atg gct ttc aaa tct ctg ctg tct ttc gtt tcg gtt   50
                Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val
                 1               5                   10
 
atc ggt gcg ctc cag ggt gcg aac gct gct ctg acc cgt cgt gtt gcg   98
Ile Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala
         15                  20                  25
 
tgc ccg gac ggt gtt aat acc gcg acc aat gct gct tgt tgc cag ctg   146
Cys Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu
     30                  35                  40
 
ttc gcg gtt cgt gaa gac ctc cag cag aac ctg ttc cac ggt ggt ctg   194
Phe Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu
 45                  50                  55                  60
 
tgc act gcg gag gct cac gaa tct ctc cgt ctg acc ttt cac gac gcg   242
Cys Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala
                 65                  70                  75
 
att gcg atc tct cca gcg ttg gaa gct cag ggt atc ttc ggt ggt ggt   290
Ile Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly
             80                  85                  90
 
ggc gct gat ggt tct atc gcg atc ttc cca gaa atc gaa acc aac ttc   338
Gly Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe
         95                 100                 105
 
cac ccg aac atc ggt ctg gac gaa atc atc gaa ctc cag aaa ccg ttc   386
His Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe
    110                 115                 120
 
atc gct cgt cac aac atc tcc gtt gct gat ttc atc cag ttc gcg ggt   434
Ile Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly
125                 130                 135                 140
 
gct atc ggt gcg tct aac tgt gcg ggt gcg cca caa ctg gct gct ttc   482
Ala Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe
                145                 150                 155
 
gtt ggt cgt aaa gac gcg act cag cca gct ccg gat ggt ctg gtt cca   530
Val Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro
            160                 165                 170
 
gaa ccg ttc cac acc ccg gac cag atc ttt gat cgt ttg gcg gac gcg   578
Glu Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala
        175                 180                 185
 
tct cag ggt gag ttc gat ccg att ctg acc gtt tgg ctg ctg acc gcg   626
Ser Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala
    190                 195                 200
 
cac acc gtt gct gct gcg aac gac gtt gac ccg acc aaa tct ggt ctg   674
His Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu
205                 210                 215                 220
 
ccg ttc gac tct acc ccg gaa ctg tgg gac acc cag ttc ttc ttg gaa   722
Pro Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu
                225                 230                 235
 
act cag ctg cgt ggt act tct ttc cca ggc tct ggt ggt aac caa ggt   770
Thr Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly
            240                 245                 250
 
gaa gtt gaa tct ccg ctg gct ggt gaa atg cgt ctc cag tct gac cac   818
Glu Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His
        255                 260                 265
 
acc atc gct cgt gat tct cgt acc gcg tgc gaa tgg cag tct ttc gtt   866
Thr Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val
    270                 275                 280
 
gac aac cag ccg aaa gct cag cag atg ttc caa ttc gtg ttc cat gac   914
Asp Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp
285                 290                 295                 300
 
ctg tct atc ttc ggt cag gac atc aac acc ctg gtt gac tgc act gaa   962
Leu Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu
                305                 310                 315
 
gtt gtt ccg att ccg gct gat ccg cag ggc cac acc cat ttc cca gcg   1010
Val Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala
            320                 325                 330
 
ggt ctc agc aac gcg gac atc gaa cag gct tgc gca gaa acc ccg ttc   1058
Gly Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe
        335                 340                 345
 
cca acc ttt ccg acc gac cca ggt ccg aaa acc gct gtt gct cca gtt   1106
Pro Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val
    350                 355                 360
 
cca aaa cct ccg gca gca cgt aaa actagtcagt gcct                   1144
Pro Lys Pro Pro Ala Ala Arg Lys
365                 370
 

<210> 62
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 62
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 63
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1116)

<400> 63
atg gcc ttt aaa tct tta ttg tct ttt gtt tct gtt att gga gct ttg   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
caa gga gct aat gca gca ttg act aga aga gtt gct tgt cca gat gga   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtt aat act gct act aac gct gct tgt tgt caa ttg ttt gca gtt aga   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gaa gat ttg caa caa aat tta ttt cat gga gga ttg tgt act gct gaa   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gct cat gaa tct tta aga ttg act ttt cat gat gca atc gct att tca   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
cct gct tta gag gct caa gga att ttt ggc gga ggt gga gct gat gga   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tct att gct att ttt cca gaa att gaa act aat ttc cac cca aat ata   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
gga ttg gat gaa att att gaa ttg caa aag cca ttt att gct aga cat   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aac att tct gtg gct gat ttt atc cag ttc gca ggt gct att gga gct   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
tct aac tgt gct gga gcc cca caa ttg gca gct ttt gtt ggt aga aaa   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gat gct act caa cca gct cct gac ggt tta gtt cca gaa cca ttt cat   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
aca cca gat caa att ttc gat aga ttg gct gac gca tca caa ggt gag   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttc gat cct att ttg act gtt tgg ttg ttg act gct cat act gtt gcc   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gct gct aat gat gtt gat cca act aaa tct gga ttg cca ttt gat tct   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
act cct gaa ttg tgg gat act caa ttc ttt tta gaa act caa tta aga   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
ggt act tct ttt cca gga tct gga gga aat caa gga gaa gtt gaa tca   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
cca ttg gct gga gaa atg aga ttg cag tct gat cat act att gct aga   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gat tct aga act gct tgt gaa tgg caa tct ttt gtg gat aat caa cca   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aag gct cag caa atg ttt caa ttt gtt ttt cat gat ttg tct att ttt   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
ggt caa gac att aat act tta gtt gat tgt act gaa gtt gtt cct att   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
cca gct gac cca caa gga cat act cat ttt cca gca ggt ttg tca aat   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gca gac att gaa cag gct tgt gct gaa act cca ttt cca act ttt cca   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
act gat cct gga cca aaa aca gca gtt gca cca gta cca aaa cct ccc   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gca gct aga aaa                                                   1116
Ala Ala Arg Lys
    370
 

<210> 64
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 64
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 65
<211> 1138
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1127)

<400> 65
tactcaagct t atg gcc ttt aaa tct tta ttg tct ttt gtt tct gtt att  50
             Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile
              1               5                   10
 
gga gct ttg caa gga gct aat gca gca ttg act aga aga gtt gct tgt   98
Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys
     15                  20                  25
 
cca gat gga gtt aat act gct act aac gct gct tgt tgt caa ttg ttt   146
Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe
 30                  35                  40                  45
 
gca gtt aga gaa gat ttg caa caa aat tta ttt cat gga gga ttg tgt   194
Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys
                 50                  55                  60
 
act gct gaa gct cat gaa tct tta aga ttg act ttt cat gat gca atc   242
Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
             65                  70                  75
 
gct att tca cct gct tta gag gct caa gga att ttt ggc gga ggt gga   290
Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly
         80                  85                  90
 
gct gat gga tct att gct att ttt cca gaa att gaa act aat ttc cac   338
Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His
     95                 100                 105
 
cca aat ata gga ttg gat gaa att att gaa ttg caa aag cca ttt att   386
Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile
110                 115                 120                 125
 
gct aga cat aac att tct gtg gct gat ttt atc cag ttc gca ggt gct   434
Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala
                130                 135                 140
 
att gga gct tct aac tgt gct gga gcc cca caa ttg gca gct ttt gtt   482
Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val
            145                 150                 155
 
ggt aga aaa gat gct act caa cca gct cct gac ggt tta gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu
        160                 165                 170
 
cca ttt cat aca cca gat caa att ttc gat aga ttg gct gac gca tca   578
Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser
    175                 180                 185
 
caa ggt gag ttc gat cct att ttg act gtt tgg ttg ttg act gct cat   626
Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His
190                 195                 200                 205
 
act gtt gcc gct gct aat gat gtt gat cca act aaa tct gga ttg cca   674
Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro
                210                 215                 220
 
ttt gat tct act cct gaa ttg tgg gat act caa ttc ttt tta gaa act   722
Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr
            225                 230                 235
 
caa tta aga ggt act tct ttt cca gga tct gga gga aat caa gga gaa   770
Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu
        240                 245                 250
 
gtt gaa tca cca ttg gct gga gaa atg aga ttg cag tct gat cat act   818
Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr
    255                 260                 265
 
att gct aga gat tct aga act gct tgt gaa tgg caa tct ttt gtg gat   866
Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp
270                 275                 280                 285
 
aat caa cca aag gct cag caa atg ttt caa ttt gtt ttt cat gat ttg   914
Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu
                290                 295                 300
 
tct att ttt ggt caa gac att aat act tta gtt gat tgt act gaa gtt   962
Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val
            305                 310                 315
 
gtt cct att cca gct gac cca caa gga cat act cat ttt cca gca ggt   1010
Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly
        320                 325                 330
 
ttg tca aat gca gac att gaa cag gct tgt gct gaa act cca ttt cca   1058
Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro
    335                 340                 345
 
act ttt cca act gat cct gga cca aaa aca gca gtt gca cca gta cca   1106
Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro
350                 355                 360                 365
 
aaa cct ccc gca gct aga aaa gaattccgat g                          1138
Lys Pro Pro Ala Ala Arg Lys
                370
 

<210> 66
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 66
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 67
<211> 1144
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1130)

<400> 67
gaatactcca tatg atg gcc ttt aaa tct tta ttg tct ttt gtt tct gtt   50
                Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val
                 1               5                   10
 
att gga gct ttg caa gga gct aat gca gca ttg act aga aga gtt gct   98
Ile Gly Ala Leu Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala
         15                  20                  25
 
tgt cca gat gga gtt aat act gct act aac gct gct tgt tgt caa ttg   146
Cys Pro Asp Gly Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu
     30                  35                  40
 
ttt gca gtt aga gaa gat ttg caa caa aat tta ttt cat gga gga ttg   194
Phe Ala Val Arg Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu
 45                  50                  55                  60
 
tgt act gct gaa gct cat gaa tct tta aga ttg act ttt cat gat gca   242
Cys Thr Ala Glu Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala
                 65                  70                  75
 
atc gct att tca cct gct tta gag gct caa gga att ttt ggc gga ggt   290
Ile Ala Ile Ser Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly
             80                  85                  90
 
gga gct gat gga tct att gct att ttt cca gaa att gaa act aat ttc   338
Gly Ala Asp Gly Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe
         95                 100                 105
 
cac cca aat ata gga ttg gat gaa att att gaa ttg caa aag cca ttt   386
His Pro Asn Ile Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe
    110                 115                 120
 
att gct aga cat aac att tct gtg gct gat ttt atc cag ttc gca ggt   434
Ile Ala Arg His Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly
125                 130                 135                 140
 
gct att gga gct tct aac tgt gct gga gcc cca caa ttg gca gct ttt   482
Ala Ile Gly Ala Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe
                145                 150                 155
 
gtt ggt aga aaa gat gct act caa cca gct cct gac ggt tta gtt cca   530
Val Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro
            160                 165                 170
 
gaa cca ttt cat aca cca gat caa att ttc gat aga ttg gct gac gca   578
Glu Pro Phe His Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala
        175                 180                 185
 
tca caa ggt gag ttc gat cct att ttg act gtt tgg ttg ttg act gct   626
Ser Gln Gly Glu Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala
    190                 195                 200
 
cat act gtt gcc gct gct aat gat gtt gat cca act aaa tct gga ttg   674
His Thr Val Ala Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu
205                 210                 215                 220
 
cca ttt gat tct act cct gaa ttg tgg gat act caa ttc ttt tta gaa   722
Pro Phe Asp Ser Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu
                225                 230                 235
 
act caa tta aga ggt act tct ttt cca gga tct gga gga aat caa gga   770
Thr Gln Leu Arg Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly
            240                 245                 250
 
gaa gtt gaa tca cca ttg gct gga gaa atg aga ttg cag tct gat cat   818
Glu Val Glu Ser Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His
        255                 260                 265
 
act att gct aga gat tct aga act gct tgt gaa tgg caa tct ttt gtg   866
Thr Ile Ala Arg Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val
    270                 275                 280
 
gat aat caa cca aag gct cag caa atg ttt caa ttt gtt ttt cat gat   914
Asp Asn Gln Pro Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp
285                 290                 295                 300
 
ttg tct att ttt ggt caa gac att aat act tta gtt gat tgt act gaa   962
Leu Ser Ile Phe Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu
                305                 310                 315
 
gtt gtt cct att cca gct gac cca caa gga cat act cat ttt cca gca   1010
Val Val Pro Ile Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala
            320                 325                 330
 
ggt ttg tca aat gca gac att gaa cag gct tgt gct gaa act cca ttt   1058
Gly Leu Ser Asn Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe
        335                 340                 345
 
cca act ttt cca act gat cct gga cca aaa aca gca gtt gca cca gta   1106
Pro Thr Phe Pro Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val
    350                 355                 360
 
cca aaa cct ccc gca gct aga aaa actagtcagt gcct                   1144
Pro Lys Pro Pro Ala Ala Arg Lys
365                 370
 

<210> 68
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 68
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 69
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1116)

<400> 69
atg gct ttc aaa tct tta ttg tct ttc gtt tct gtt att ggt gct ttg   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
caa ggt gca aat gca gcc ctt act agg aga gtt gct tgt cca gat ggt   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtt aat act gct aca aat gct gca tgt tgt caa ttg ttc gct gtt aga   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gaa gat ttg caa caa aat ttg ttt cat ggt ggt ttg tgt act gct gaa   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gct cat gaa tca ttg aga ttg act ttc cac gat gct att gct att tcc   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
cca gct ttg gaa gca caa ggt ata ttc ggt ggt ggc gga gca gat ggt   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tcc atc gca atc ttc cct gaa att gaa act aat ttt cat cca aat att   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
ggt ttg gac gag att att gaa ttg caa aaa cca ttc att gct aga cat   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aat att tct gtt gct gat ttc att cag ttc gcg gga gct att gga gcg   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
agt aat tgt gct gga gca cca caa ttg gca gct ttc gtt ggt aga aaa   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gat gct act caa cca gct cct gac gga ttg gtt cca gaa cct ttt cat   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
act cca gat caa att ttc gat aga ttg gcc gat gca tct caa ggt gaa   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttt gat cca att ttg act gtt tgg ttg ttg act gct cat act gtt gca   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gca gct aat gat gtt gat cca act aaa tct ggt ttg cca ttc gat tct   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
act cct gaa ttg tgg gat act caa ttc ttc ttg gaa act caa ttg cgt   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
gga aca tct ttc cct ggt agt ggt ggt aat caa ggt gag gta gaa tca   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
cca ttg gcg ggc gaa atg aga ttg caa tcg gat cat act att gct aga   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gat tct aga act gct tgt gaa tgg cag tct ttt gta gat aat caa cca   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aaa gct caa caa atg ttc cag ttc gtt ttt cat gat ttg tct att ttc   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
ggt caa gac att aat aca ttg gtg gat tgt act gaa gtt gtt cca att   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
cca gct gat cca caa ggt cat act cat ttt cct gct ggt tta agc aat   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gca gac att gaa cag gct tgt gcg gaa act cca ttt cca act ttt cca   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
act gac cct gga cca aaa act gct gtt gcc ccg gtt cca aag cca cca   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gct gca cgt aaa                                                   1116
Ala Ala Arg Lys
    370
 

<210> 70
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 70
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 71
<211> 1116
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1116)

<400> 71
atg gcc ttc aaa tct ttg ttg tct ttt gtt tct gtc att ggt gct ctt   48
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                   10                  15
 
cag ggt gct aat gcc gct tta acc cgc cgt gta gct tgt ccg gat ggt   96
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
             20                  25                  30
 
gtt aat acc gcc aca aat gca gca tgt tgt cag ttg ttt gcc gtt cgt   144
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
         35                  40                  45
 
gaa gat ttg cag cag aat ttg ttt cat ggt ggt ttg tgt acc gct gaa   192
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
     50                  55                  60
 
gct cat gaa tct ttg cgt ttg acc ttt cat gac gcc att gcc att tct   240
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
 65                  70                  75                  80
 
ccg gcc ctt gag gcg caa gga att ttt ggt ggt gga ggt gct gat ggt   288
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                 85                  90                  95
 
tct att gcc atc ttt ccc gaa att gaa acc aac ttt cat ccg aat att   336
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110
 
ggt ttg gat gaa att att gaa ttg cag aaa ccg ttt att gct cgt cat   384
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125
 
aat att tct gtt gcc gat ttt att cag ttt gct ggc gcg att gga gcc   432
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140
 
tct aat tgt gct gga gcc cca cag ttg gcc gcc ttc gtt ggt cgt aaa   480
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160
 
gat gct acc cag cct gct ccc gac gga ttg gtt cct gaa ccg ttt cat   528
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175
 
acc cca gat cag att ttt gat cgt ttg gct gat gct agt caa ggt gaa   576
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190
 
ttt gat ccg att ttg acc gtc tgg ttg ttg aca gct cat acg gtc gcc   624
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205
 
gca gct aat gat gtt gat ccg acc aaa tct ggt ttg cct ttt gat tct   672
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220
 
acc cct gaa ttg tgg gat acc cag ttt ttc ttg gaa acc caa ctt aga   720
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240
 
gga acc tct ttt ccg ggt tct ggt ggt aat cag ggc gag gtc gaa tct   768
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255
 
ccg tta gcg ggc gaa atg cgt ttg cag tct gat cat acc att gct cgg   816
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270
 
gat tct cgt acc gcg tgt gaa tgg cag tct ttt gtt gat aat cag ccg   864
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285
 
aaa gcc cag caa atg ttt cag ttt gtt ttt cat gat ttg tct att ttt   912
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300
 
ggt cag gac att aat acc ttg gtt gat tgt acc gaa gtt gtt ccg att   960
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320
 
ccg gca gat ccg cag ggt cat aca cat ttt cct gct ggt ctt agc aat   1008
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335
 
gct gat atc gaa cag gct tgt gcc gaa act cca ttc ccg acc ttt ccg   1056
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350
 
act gat cct ggt ccc aaa acg gca gtc gca cct gtt cca aaa cca ccg   1104
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365
 
gct gct cgt aag                                                   1116
Ala Ala Arg Lys
    370
 

<210> 72
<211> 372
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 72
Met Ala Phe Lys Ser Leu Leu Ser Phe Val Ser Val Ile Gly Ala Leu
 1               5                  10                  15      
Gln Gly Ala Asn Ala Ala Leu Thr Arg Arg Val Ala Cys Pro Asp Gly
            20                  25                  30          
Val Asn Thr Ala Thr Asn Ala Ala Cys Cys Gln Leu Phe Ala Val Arg
        35                  40                  45              
Glu Asp Leu Gln Gln Asn Leu Phe His Gly Gly Leu Cys Thr Ala Glu
    50                  55                  60                  
Ala His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Ala Ile Ser
65                  70                  75                  80  
Pro Ala Leu Glu Ala Gln Gly Ile Phe Gly Gly Gly Gly Ala Asp Gly
                85                  90                  95      
Ser Ile Ala Ile Phe Pro Glu Ile Glu Thr Asn Phe His Pro Asn Ile
            100                 105                 110         
Gly Leu Asp Glu Ile Ile Glu Leu Gln Lys Pro Phe Ile Ala Arg His
        115                 120                 125             
Asn Ile Ser Val Ala Asp Phe Ile Gln Phe Ala Gly Ala Ile Gly Ala
    130                 135                 140                 
Ser Asn Cys Ala Gly Ala Pro Gln Leu Ala Ala Phe Val Gly Arg Lys
145                 150                 155                 160 
Asp Ala Thr Gln Pro Ala Pro Asp Gly Leu Val Pro Glu Pro Phe His
                165                 170                 175     
Thr Pro Asp Gln Ile Phe Asp Arg Leu Ala Asp Ala Ser Gln Gly Glu
            180                 185                 190         
Phe Asp Pro Ile Leu Thr Val Trp Leu Leu Thr Ala His Thr Val Ala
        195                 200                 205             
Ala Ala Asn Asp Val Asp Pro Thr Lys Ser Gly Leu Pro Phe Asp Ser
    210                 215                 220                 
Thr Pro Glu Leu Trp Asp Thr Gln Phe Phe Leu Glu Thr Gln Leu Arg
225                 230                 235                 240 
Gly Thr Ser Phe Pro Gly Ser Gly Gly Asn Gln Gly Glu Val Glu Ser
                245                 250                 255     
Pro Leu Ala Gly Glu Met Arg Leu Gln Ser Asp His Thr Ile Ala Arg
            260                 265                 270         
Asp Ser Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asp Asn Gln Pro
        275                 280                 285             
Lys Ala Gln Gln Met Phe Gln Phe Val Phe His Asp Leu Ser Ile Phe
    290                 295                 300                 
Gly Gln Asp Ile Asn Thr Leu Val Asp Cys Thr Glu Val Val Pro Ile
305                 310                 315                 320 
Pro Ala Asp Pro Gln Gly His Thr His Phe Pro Ala Gly Leu Ser Asn
                325                 330                 335     
Ala Asp Ile Glu Gln Ala Cys Ala Glu Thr Pro Phe Pro Thr Phe Pro
            340                 345                 350         
Thr Asp Pro Gly Pro Lys Thr Ala Val Ala Pro Val Pro Lys Pro Pro
        355                 360                 365             
Ala Ala Arg Lys
    370         


<210> 73
<211> 1095
<212> DNA
<213> T. versicolor

<220> 
<221> CDS            
<222> (1)...(1095)

<400> 73
atg gcg ttc aag ctc ctt ggt tcc ttc gtc tcc ctc ctc gcg gcc ctt   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
cag gtc gct aac ggt gcc ctc acc cgc cgt gtg acg tgc gcc acc ggc   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
cag gtc acc tcg aac gcg gcc tgc tgc gcg ctc ttc ccc gtc atc gac   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac atc cag acg aac ctg ttc gac ggc ggc gag tgc ggc gag gag gtc   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cac gag tcc ctc cgc ctc acc ttc cac gac gcc atc ggc atc tcg ccc   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gcc atc gcc aag acc ggt gtc ttc ggt ggt gga ggc gcg gac ggc tcc   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
att gcc atc ttc gcc gac atc gag acg aac ttc cac gcg aac aac ggt   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtc gac gag atc atc ggc gag cag gcg ccc ttc atc gcc cgc cac aac   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ctc acc acc gcc gac ttc atc cag ttg gcc ggt gcc atc ggt gtc tcc   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aac tgc cct ggc gcg ccc cgc ctg aac gtc ttc att ggc cgc aag gac   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gcg acc cag ccc gct ccc gac ctg acg gtc ccc gag ccc ttc gac gac   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtc acc aag att ctt gct cgc ttc gag gat gcc ggc aag ttc acc ccc   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gct gag gtt gtt gcc ctg ctc gcc tcg cac acg atc gcc gct gcc gac   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cac gtc gac ccc acc atc ccg gga acg ccc ttc gac tcc acc ccc gag   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ctg ttc gac acc cag ttc ttc atc gag acc cag ctc cgc ggc acg ctc   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttc ccc ggc aac ggc agc aac cag ggt gag gtc cag tct ccc ctc ggc   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
ggt gag ctc cgt ctc cag tcc gac gga cta ctt gcc cgc gac cag cgc   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
acg gcc tgc gag tgg cag tcg ttc gtc aac aac cag gcg aag ctc cag   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
agc gcg ttc aag gcc gcg ttc gcg agg atg acc gtg ctc ggc cag aac   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
acg cgc gcg ctc atc gac tgc tcg gac gtc gtc ccc acc ccg ccc gcc   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
ccc gcc agc aag gca cac ttc ccc gcc ggc ctc tcc cgc cgc gac atc   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gag cag gcg tgc cgc gcg acg ccc ttc ccc acg ctc ccc act gac ccc   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
gga ccc gtt acc acc gtc gcc cct gtc ccc ccg tcc taa               1095
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser  *
        355                 360
 

<210> 74
<211> 364
<212> PRT
<213> T. versicolor

<400> 74
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 75
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 75
atg gca ttt aaa ttg ttg ggt tct ttt gta tct ttg ttg gct gct ttg   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
caa gtt gct aat ggt gct ttg act agg aga gtt act tgt gca act ggt   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
caa gtt act tca aat gct gca tgt tgt gct ctc ttt cca gta att gat   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac att cag act aat ttg ttt gat ggt ggt gaa tgt ggt gaa gaa gtt   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cat gaa tct ttg aga ttg act ttt cat gat gct att gga att tca cca   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gct att gca aag aca ggt gtt ttt gga ggt ggt ggt gca gat ggt tct   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
att gct att ttt gct gat ata gaa act aat ttt cat gct aat aat ggt   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtt gat gaa att att ggt gaa caa gct cca ttt att gct aga cat aat   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ttg act act gct gat ttt ata caa ttg gct ggt gct att ggt gtt tca   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aat tgt cca ggt gct cct aga tta aat gtt ttt att ggt aga aaa gat   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gct aca caa cca gct cca gat ttg act gtt cca gaa cca ttt gat gat   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtt act aaa att ttg gct aga ttt gaa gat gca ggt aaa ttt act cca   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gct gag gtt gtt gct ttg ttg gct tct cat act ata gcc gct gct gat   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cat gtt gat cca act att cca ggt act cca ttt gat tca act cct gaa   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ttg ttt gat act caa ttc ttt att gaa act cag ttg aga ggt aca ttg   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttt cca ggt aat ggt tct aat caa ggt gaa gtt caa tct cct ttg ggt   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
ggt gaa ttg agg ttg caa tct gat ggt ttg ttg gct aga gat caa aga   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
act gct tgt gaa tgg caa tct ttc gtt aat aat caa gct aaa ttg cag   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
tct gct ttt aaa gct gct ttt gct aga atg act gtt ttg ggt caa aat   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
act aga gct ttg att gat tgt tct gac gtc gtt cca act cca cca gct   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
cca gct tct aag gct cat ttt cca gca ggt ttg tct aga agg gat ata   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gaa cag gct tgt aga gca act cca ttt cca aca ttg cca aca gat cct   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
ggt cct gtt act act gtt gct cct gta cca cca tca                   1092
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360
 

<210> 76
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 76
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 77
<211> 1120
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1106)

<400> 77
gaatactcca tatg atg gca ttt aaa ttg ttg ggt tct ttt gta tct ttg   50
                Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu
                 1               5                   10
 
ttg gct gct ttg caa gtt gct aat ggt gct ttg act agg aga gtt act   98
Leu Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr
         15                  20                  25
 
tgt gca act ggt caa gtt act tca aat gct gca tgt tgt gct ctc ttt   146
Cys Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe
     30                  35                  40
 
cca gta att gat gac att cag act aat ttg ttt gat ggt ggt gaa tgt   194
Pro Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys
 45                  50                  55                  60
 
ggt gaa gaa gtt cat gaa tct ttg aga ttg act ttt cat gat gct att   242
Gly Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
                 65                  70                  75
 
gga att tca cca gct att gca aag aca ggt gtt ttt gga ggt ggt ggt   290
Gly Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly
             80                  85                  90
 
gca gat ggt tct att gct att ttt gct gat ata gaa act aat ttt cat   338
Ala Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His
         95                 100                 105
 
gct aat aat ggt gtt gat gaa att att ggt gaa caa gct cca ttt att   386
Ala Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile
    110                 115                 120
 
gct aga cat aat ttg act act gct gat ttt ata caa ttg gct ggt gct   434
Ala Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala
125                 130                 135                 140
 
att ggt gtt tca aat tgt cca ggt gct cct aga tta aat gtt ttt att   482
Ile Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile
                145                 150                 155
 
ggt aga aaa gat gct aca caa cca gct cca gat ttg act gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu
            160                 165                 170
 
cca ttt gat gat gtt act aaa att ttg gct aga ttt gaa gat gca ggt   578
Pro Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly
        175                 180                 185
 
aaa ttt act cca gct gag gtt gtt gct ttg ttg gct tct cat act ata   626
Lys Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile
    190                 195                 200
 
gcc gct gct gat cat gtt gat cca act att cca ggt act cca ttt gat   674
Ala Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp
205                 210                 215                 220
 
tca act cct gaa ttg ttt gat act caa ttc ttt att gaa act cag ttg   722
Ser Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu
                225                 230                 235
 
aga ggt aca ttg ttt cca ggt aat ggt tct aat caa ggt gaa gtt caa   770
Arg Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln
            240                 245                 250
 
tct cct ttg ggt ggt gaa ttg agg ttg caa tct gat ggt ttg ttg gct   818
Ser Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala
        255                 260                 265
 
aga gat caa aga act gct tgt gaa tgg caa tct ttc gtt aat aat caa   866
Arg Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln
    270                 275                 280
 
gct aaa ttg cag tct gct ttt aaa gct gct ttt gct aga atg act gtt   914
Ala Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val
285                 290                 295                 300
 
ttg ggt caa aat act aga gct ttg att gat tgt tct gac gtc gtt cca   962
Leu Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro
                305                 310                 315
 
act cca cca gct cca gct tct aag gct cat ttt cca gca ggt ttg tct   1010
Thr Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser
            320                 325                 330
 
aga agg gat ata gaa cag gct tgt aga gca act cca ttt cca aca ttg   1058
Arg Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu
        335                 340                 345
 
cca aca gat cct ggt cct gtt act act gtt gct cct gta cca cca tca   1106
Pro Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
    350                 355                 360
 
actagtcagt gcct                                                   1120

<210> 78
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 78
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 79
<211> 1114
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1103)

<400> 79
tactcaagct t atg gca ttt aaa ttg ttg ggt tct ttt gta tct ttg ttg  50
             Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu
              1               5                   10
 
gct gct ttg caa gtt gct aat ggt gct ttg act agg aga gtt act tgt   98
Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys
     15                  20                  25
 
gca act ggt caa gtt act tca aat gct gca tgt tgt gct ctc ttt cca   146
Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro
 30                  35                  40                  45
 
gta att gat gac att cag act aat ttg ttt gat ggt ggt gaa tgt ggt   194
Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly
                 50                  55                  60
 
gaa gaa gtt cat gaa tct ttg aga ttg act ttt cat gat gct att gga   242
Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly
             65                  70                  75
 
att tca cca gct att gca aag aca ggt gtt ttt gga ggt ggt ggt gca   290
Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala
         80                  85                  90
 
gat ggt tct att gct att ttt gct gat ata gaa act aat ttt cat gct   338
Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala
     95                 100                 105
 
aat aat ggt gtt gat gaa att att ggt gaa caa gct cca ttt att gct   386
Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala
110                 115                 120                 125
 
aga cat aat ttg act act gct gat ttt ata caa ttg gct ggt gct att   434
Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile
                130                 135                 140
 
ggt gtt tca aat tgt cca ggt gct cct aga tta aat gtt ttt att ggt   482
Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly
            145                 150                 155
 
aga aaa gat gct aca caa cca gct cca gat ttg act gtt cca gaa cca   530
Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro
        160                 165                 170
 
ttt gat gat gtt act aaa att ttg gct aga ttt gaa gat gca ggt aaa   578
Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys
    175                 180                 185
 
ttt act cca gct gag gtt gtt gct ttg ttg gct tct cat act ata gcc   626
Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala
190                 195                 200                 205
 
gct gct gat cat gtt gat cca act att cca ggt act cca ttt gat tca   674
Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser
                210                 215                 220
 
act cct gaa ttg ttt gat act caa ttc ttt att gaa act cag ttg aga   722
Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg
            225                 230                 235
 
ggt aca ttg ttt cca ggt aat ggt tct aat caa ggt gaa gtt caa tct   770
Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser
        240                 245                 250
 
cct ttg ggt ggt gaa ttg agg ttg caa tct gat ggt ttg ttg gct aga   818
Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg
    255                 260                 265
 
gat caa aga act gct tgt gaa tgg caa tct ttc gtt aat aat caa gct   866
Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala
270                 275                 280                 285
 
aaa ttg cag tct gct ttt aaa gct gct ttt gct aga atg act gtt ttg   914
Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu
                290                 295                 300
 
ggt caa aat act aga gct ttg att gat tgt tct gac gtc gtt cca act   962
Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr
            305                 310                 315
 
cca cca gct cca gct tct aag gct cat ttt cca gca ggt ttg tct aga   1010
Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg
        320                 325                 330
 
agg gat ata gaa cag gct tgt aga gca act cca ttt cca aca ttg cca   1058
Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro
    335                 340                 345
 
aca gat cct ggt cct gtt act act gtt gct cct gta cca cca tca       1103
Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
350                 355                 360
 
gaattccgat g                                                      1114

<210> 80
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 80
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 81
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 81
atg gct ttc aaa ctg ctg ggt tct ttc gtt agc ctg ctc gcg gcg ctc   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
cag gtt gcg aac ggt gct ctg act cgt cgt gtt acc tgc gct acc ggt   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
cag gtt acc tct aat gct gct tgc tgt gcg ctc ttt ccg gtt att gac   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac atc cag acc aac ctg ttc gac ggt ggt gaa tgc ggt gaa gaa gtt   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cac gaa tct ctg cgt ctg acc ttc cac gat gcg atc ggt atc tct ccg   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gcg att gcg aag act ggt gtt ttc ggt ggt ggc ggc gcg gat ggt tct   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
atc gct atc ttc gcg gac atc gaa acc aac ttc cac gcg aac aac ggt   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtt gac gaa atc atc ggt gaa cag gct ccg ttc atc gct cgt cac aac   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ctg act acc gca gac ttc att caa ctg gct ggt gct att ggt gtt tcg   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aac tgt ccg ggc gct cca cgt ctg aat gtt ttc atc ggt cgt aaa gac   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gcg act cag cca gcg ccg gat ctg acc gtt cca gaa cca ttc gac gac   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtt act aaa atc ctg gct cgt ttc gaa gac gcg ggt aaa ttc acc cca   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gcg gaa gtt gtt gct ctg ctg gct tct cac acc att gct gcg gcg gac   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cac gtt gac cca acc atc ccg ggt act ccg ttc gac tct acc ccg gaa   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ctg ttc gac acc cag ttc ttc atc gaa act cag ctc cgt ggc acc ctc   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttc cca ggt aac ggt tct aac cag ggt gaa gtt cag tct ccg ctg ggt   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
ggt gaa ctg cgt ctc cag tct gac ggt ctg ctg gct cgc gat caa cgt   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
acc gct tgc gaa tgg cag tct ttc gtt aac aac cag gct aaa ctc cag   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
tct gcg ttc aag gcg gcg ttt gcg cgt atg acc gtt ctg ggt cag aac   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
acc cgt gct ctg att gac tgc tct gac gtt gtt ccg act cct cct gca   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
ccg gct tcc aag gcg cac ttt ccg gcg ggt ctg tct cgt cgt gac atc   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gaa cag gct tgc cgt gcg acc ccg ttc cca acc ctg ccg acc gac cct   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
ggt ccg gtt acc act gtt gct cca gtt cca ccg tcc                   1092
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360
 

<210> 82
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 82
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 83
<211> 1114
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1103)

<400> 83
tactcaagct t atg gct ttc aaa ctg ctg ggt tct ttc gtt agc ctg ctc  50
             Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu
              1               5                   10
 
gcg gcg ctc cag gtt gcg aac ggt gct ctg act cgt cgt gtt acc tgc   98
Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys
     15                  20                  25
 
gct acc ggt cag gtt acc tct aat gct gct tgc tgt gcg ctc ttt ccg   146
Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro
 30                  35                  40                  45
 
gtt att gac gac atc cag acc aac ctg ttc gac ggt ggt gaa tgc ggt   194
Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly
                 50                  55                  60
 
gaa gaa gtt cac gaa tct ctg cgt ctg acc ttc cac gat gcg atc ggt   242
Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly
             65                  70                  75
 
atc tct ccg gcg att gcg aag act ggt gtt ttc ggt ggt ggc ggc gcg   290
Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala
         80                  85                  90
 
gat ggt tct atc gct atc ttc gcg gac atc gaa acc aac ttc cac gcg   338
Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala
     95                 100                 105
 
aac aac ggt gtt gac gaa atc atc ggt gaa cag gct ccg ttc atc gct   386
Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala
110                 115                 120                 125
 
cgt cac aac ctg act acc gca gac ttc att caa ctg gct ggt gct att   434
Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile
                130                 135                 140
 
ggt gtt tcg aac tgt ccg ggc gct cca cgt ctg aat gtt ttc atc ggt   482
Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly
            145                 150                 155
 
cgt aaa gac gcg act cag cca gcg ccg gat ctg acc gtt cca gaa cca   530
Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro
        160                 165                 170
 
ttc gac gac gtt act aaa atc ctg gct cgt ttc gaa gac gcg ggt aaa   578
Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys
    175                 180                 185
 
ttc acc cca gcg gaa gtt gtt gct ctg ctg gct tct cac acc att gct   626
Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala
190                 195                 200                 205
 
gcg gcg gac cac gtt gac cca acc atc ccg ggt act ccg ttc gac tct   674
Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser
                210                 215                 220
 
acc ccg gaa ctg ttc gac acc cag ttc ttc atc gaa act cag ctc cgt   722
Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg
            225                 230                 235
 
ggc acc ctc ttc cca ggt aac ggt tct aac cag ggt gaa gtt cag tct   770
Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser
        240                 245                 250
 
ccg ctg ggt ggt gaa ctg cgt ctc cag tct gac ggt ctg ctg gct cgc   818
Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg
    255                 260                 265
 
gat caa cgt acc gct tgc gaa tgg cag tct ttc gtt aac aac cag gct   866
Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala
270                 275                 280                 285
 
aaa ctc cag tct gcg ttc aag gcg gcg ttt gcg cgt atg acc gtt ctg   914
Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu
                290                 295                 300
 
ggt cag aac acc cgt gct ctg att gac tgc tct gac gtt gtt ccg act   962
Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr
            305                 310                 315
 
cct cct gca ccg gct tcc aag gcg cac ttt ccg gcg ggt ctg tct cgt   1010
Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg
        320                 325                 330
 
cgt gac atc gaa cag gct tgc cgt gcg acc ccg ttc cca acc ctg ccg   1058
Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro
    335                 340                 345
 
acc gac cct ggt ccg gtt acc act gtt gct cca gtt cca ccg tcc       1103
Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
350                 355                 360
 
gaattccgat g                                                      1114

<210> 84
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 84
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 85
<211> 1120
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1106)

<400> 85
gaatactcca tatg atg gct ttc aaa ctg ctg ggt tct ttc gtt agc ctg   50
                Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu
                 1               5                   10
 
ctc gcg gcg ctc cag gtt gcg aac ggt gct ctg act cgt cgt gtt acc   98
Leu Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr
         15                  20                  25
 
tgc gct acc ggt cag gtt acc tct aat gct gct tgc tgt gcg ctc ttt   146
Cys Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe
     30                  35                  40
 
ccg gtt att gac gac atc cag acc aac ctg ttc gac ggt ggt gaa tgc   194
Pro Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys
 45                  50                  55                  60
 
ggt gaa gaa gtt cac gaa tct ctg cgt ctg acc ttc cac gat gcg atc   242
Gly Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
                 65                  70                  75
 
ggt atc tct ccg gcg att gcg aag act ggt gtt ttc ggt ggt ggc ggc   290
Gly Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly
             80                  85                  90
 
gcg gat ggt tct atc gct atc ttc gcg gac atc gaa acc aac ttc cac   338
Ala Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His
         95                 100                 105
 
gcg aac aac ggt gtt gac gaa atc atc ggt gaa cag gct ccg ttc atc   386
Ala Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile
    110                 115                 120
 
gct cgt cac aac ctg act acc gca gac ttc att caa ctg gct ggt gct   434
Ala Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala
125                 130                 135                 140
 
att ggt gtt tcg aac tgt ccg ggc gct cca cgt ctg aat gtt ttc atc   482
Ile Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile
                145                 150                 155
 
ggt cgt aaa gac gcg act cag cca gcg ccg gat ctg acc gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu
            160                 165                 170
 
cca ttc gac gac gtt act aaa atc ctg gct cgt ttc gaa gac gcg ggt   578
Pro Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly
        175                 180                 185
 
aaa ttc acc cca gcg gaa gtt gtt gct ctg ctg gct tct cac acc att   626
Lys Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile
    190                 195                 200
 
gct gcg gcg gac cac gtt gac cca acc atc ccg ggt act ccg ttc gac   674
Ala Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp
205                 210                 215                 220
 
tct acc ccg gaa ctg ttc gac acc cag ttc ttc atc gaa act cag ctc   722
Ser Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu
                225                 230                 235
 
cgt ggc acc ctc ttc cca ggt aac ggt tct aac cag ggt gaa gtt cag   770
Arg Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln
            240                 245                 250
 
tct ccg ctg ggt ggt gaa ctg cgt ctc cag tct gac ggt ctg ctg gct   818
Ser Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala
        255                 260                 265
 
cgc gat caa cgt acc gct tgc gaa tgg cag tct ttc gtt aac aac cag   866
Arg Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln
    270                 275                 280
 
gct aaa ctc cag tct gcg ttc aag gcg gcg ttt gcg cgt atg acc gtt   914
Ala Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val
285                 290                 295                 300
 
ctg ggt cag aac acc cgt gct ctg att gac tgc tct gac gtt gtt ccg   962
Leu Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro
                305                 310                 315
 
act cct cct gca ccg gct tcc aag gcg cac ttt ccg gcg ggt ctg tct   1010
Thr Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser
            320                 325                 330
 
cgt cgt gac atc gaa cag gct tgc cgt gcg acc ccg ttc cca acc ctg   1058
Arg Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu
        335                 340                 345
 
ccg acc gac cct ggt ccg gtt acc act gtt gct cca gtt cca ccg tcc   1106
Pro Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
    350                 355                 360
 
actagtcagt gcct                                                   1120

<210> 86
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 86
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 87
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 87
atg gcc ttt aaa ttg ttg gga tct ttt gtt tca ttg ttg gct gca ttg   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
caa gtt gct aat gga gct ttg act aga aga gtt aca tgt gct act gga   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
caa gtt act tct aac gct gct tgt tgt gct ttg ttt cca gtt att gat   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac att caa act aat ttg ttc gat gga ggt gaa tgt gga gaa gaa gtt   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cat gaa tct tta aga ttg act ttt cat gat gct att gga att tct cca   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gct att gca aag aca gga gtt ttc gga ggt gga gga gct gat gga tct   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
att gct att ttt gca gac att gaa act aat ttt cat gct aat aat gga   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtt gat gaa att att gga gaa caa gct cct ttt att gct aga cat aat   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ttg act act gct gat ttt att caa tta gct ggt gct att gga gtt tct   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aat tgt cca ggt gct cct aga tta aat gtt ttt att ggt aga aaa gat   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gct act cag cca gct cca gat ttg act gtt cca gaa cct ttt gat gat   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtt act aaa att ttg gct aga ttt gag gat gct gga aaa ttt aca cct   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gct gaa gtt gtt gct ttg ttg gct tct cat act att gct gcc gct gat   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cat gtt gat cca act att cca ggt act cca ttt gat tct act cct gaa   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ttg ttt gat act caa ttc ttt att gaa act caa tta aga ggt act tta   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttt cca gga aac gga tct aat caa gga gaa gtt caa tca cca ttg gga   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
gga gaa ttg cgt ttg cag agt gat ggt ttg ttg gct aga gat caa aga   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
act gct tgt gaa tgg caa tct ttt gtt aat aat caa gct aaa ttg caa   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
tct gct ttt aaa gct gcc ttt gca aga atg act gtg ttg gga caa aat   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
act aga gct ttg att gat tgt tct gac gtt gtt cct act cct ccc gca   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
cca gct tct aag gct cat ttt cct gct ggt ttg tct aga aga gat ata   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gaa cag gct tgt aga gct act cca ttc cca act tta cca act gat cca   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
ggt cct gtt act act gtg gct cct gtt cca cca tct                   1092
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360
 

<210> 88
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 88
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 89
<211> 1120
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1106)

<400> 89
gaatactcca tatg atg gcc ttt aaa ttg ttg gga tct ttt gtt tca ttg   50
                Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu
                 1               5                   10
 
ttg gct gca ttg caa gtt gct aat gga gct ttg act aga aga gtt aca   98
Leu Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr
         15                  20                  25
 
tgt gct act gga caa gtt act tct aac gct gct tgt tgt gct ttg ttt   146
Cys Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe
     30                  35                  40
 
cca gtt att gat gac att caa act aat ttg ttc gat gga ggt gaa tgt   194
Pro Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys
 45                  50                  55                  60
 
gga gaa gaa gtt cat gaa tct tta aga ttg act ttt cat gat gct att   242
Gly Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile
                 65                  70                  75
 
gga att tct cca gct att gca aag aca gga gtt ttc gga ggt gga gga   290
Gly Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly
             80                  85                  90
 
gct gat gga tct att gct att ttt gca gac att gaa act aat ttt cat   338
Ala Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His
         95                 100                 105
 
gct aat aat gga gtt gat gaa att att gga gaa caa gct cct ttt att   386
Ala Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile
    110                 115                 120
 
gct aga cat aat ttg act act gct gat ttt att caa tta gct ggt gct   434
Ala Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala
125                 130                 135                 140
 
att gga gtt tct aat tgt cca ggt gct cct aga tta aat gtt ttt att   482
Ile Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile
                145                 150                 155
 
ggt aga aaa gat gct act cag cca gct cca gat ttg act gtt cca gaa   530
Gly Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu
            160                 165                 170
 
cct ttt gat gat gtt act aaa att ttg gct aga ttt gag gat gct gga   578
Pro Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly
        175                 180                 185
 
aaa ttt aca cct gct gaa gtt gtt gct ttg ttg gct tct cat act att   626
Lys Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile
    190                 195                 200
 
gct gcc gct gat cat gtt gat cca act att cca ggt act cca ttt gat   674
Ala Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp
205                 210                 215                 220
 
tct act cct gaa ttg ttt gat act caa ttc ttt att gaa act caa tta   722
Ser Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu
                225                 230                 235
 
aga ggt act tta ttt cca gga aac gga tct aat caa gga gaa gtt caa   770
Arg Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln
            240                 245                 250
 
tca cca ttg gga gga gaa ttg cgt ttg cag agt gat ggt ttg ttg gct   818
Ser Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala
        255                 260                 265
 
aga gat caa aga act gct tgt gaa tgg caa tct ttt gtt aat aat caa   866
Arg Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln
    270                 275                 280
 
gct aaa ttg caa tct gct ttt aaa gct gcc ttt gca aga atg act gtg   914
Ala Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val
285                 290                 295                 300
 
ttg gga caa aat act aga gct ttg att gat tgt tct gac gtt gtt cct   962
Leu Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro
                305                 310                 315
 
act cct ccc gca cca gct tct aag gct cat ttt cct gct ggt ttg tct   1010
Thr Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser
            320                 325                 330
 
aga aga gat ata gaa cag gct tgt aga gct act cca ttc cca act tta   1058
Arg Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu
        335                 340                 345
 
cca act gat cca ggt cct gtt act act gtg gct cct gtt cca cca tct   1106
Pro Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
    350                 355                 360
 
actagtcagt gcct                                                   1120

<210> 90
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 90
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 91
<211> 1114
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1103)

<400> 91
tactcaagct t atg gcc ttt aaa ttg ttg gga tct ttt gtt tca ttg ttg  50
             Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu
              1               5                   10
 
gct gca ttg caa gtt gct aat gga gct ttg act aga aga gtt aca tgt   98
Ala Ala Leu Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys
     15                  20                  25
 
gct act gga caa gtt act tct aac gct gct tgt tgt gct ttg ttt cca   146
Ala Thr Gly Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro
 30                  35                  40                  45
 
gtt att gat gac att caa act aat ttg ttc gat gga ggt gaa tgt gga   194
Val Ile Asp Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly
                 50                  55                  60
 
gaa gaa gtt cat gaa tct tta aga ttg act ttt cat gat gct att gga   242
Glu Glu Val His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly
             65                  70                  75
 
att tct cca gct att gca aag aca gga gtt ttc gga ggt gga gga gct   290
Ile Ser Pro Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala
         80                  85                  90
 
gat gga tct att gct att ttt gca gac att gaa act aat ttt cat gct   338
Asp Gly Ser Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala
     95                 100                 105
 
aat aat gga gtt gat gaa att att gga gaa caa gct cct ttt att gct   386
Asn Asn Gly Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala
110                 115                 120                 125
 
aga cat aat ttg act act gct gat ttt att caa tta gct ggt gct att   434
Arg His Asn Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile
                130                 135                 140
 
gga gtt tct aat tgt cca ggt gct cct aga tta aat gtt ttt att ggt   482
Gly Val Ser Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly
            145                 150                 155
 
aga aaa gat gct act cag cca gct cca gat ttg act gtt cca gaa cct   530
Arg Lys Asp Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro
        160                 165                 170
 
ttt gat gat gtt act aaa att ttg gct aga ttt gag gat gct gga aaa   578
Phe Asp Asp Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys
    175                 180                 185
 
ttt aca cct gct gaa gtt gtt gct ttg ttg gct tct cat act att gct   626
Phe Thr Pro Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala
190                 195                 200                 205
 
gcc gct gat cat gtt gat cca act att cca ggt act cca ttt gat tct   674
Ala Ala Asp His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser
                210                 215                 220
 
act cct gaa ttg ttt gat act caa ttc ttt att gaa act caa tta aga   722
Thr Pro Glu Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg
            225                 230                 235
 
ggt act tta ttt cca gga aac gga tct aat caa gga gaa gtt caa tca   770
Gly Thr Leu Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser
        240                 245                 250
 
cca ttg gga gga gaa ttg cgt ttg cag agt gat ggt ttg ttg gct aga   818
Pro Leu Gly Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg
    255                 260                 265
 
gat caa aga act gct tgt gaa tgg caa tct ttt gtt aat aat caa gct   866
Asp Gln Arg Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala
270                 275                 280                 285
 
aaa ttg caa tct gct ttt aaa gct gcc ttt gca aga atg act gtg ttg   914
Lys Leu Gln Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu
                290                 295                 300
 
gga caa aat act aga gct ttg att gat tgt tct gac gtt gtt cct act   962
Gly Gln Asn Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr
            305                 310                 315
 
cct ccc gca cca gct tct aag gct cat ttt cct gct ggt ttg tct aga   1010
Pro Pro Ala Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg
        320                 325                 330
 
aga gat ata gaa cag gct tgt aga gct act cca ttc cca act tta cca   1058
Arg Asp Ile Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro
    335                 340                 345
 
act gat cca ggt cct gtt act act gtg gct cct gtt cca cca tct       1103
Thr Asp Pro Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
350                 355                 360
 
gaattccgat g                                                      1114

<210> 92
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 92
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 93
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 93
atg gct ttc aaa ttg ttg ggt tct ttc gtt tct tta ttg gct gct ttg   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
caa gtt gct aat ggt gct ttg act agg aga gtt act tgt gct act ggt   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
caa gtt act tct aat gct gcc tgt tgt gct ttg ttt cca gtt att gat   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac atc caa act aat ttg ttc gat ggt ggt gaa tgt ggt gaa gaa gtt   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cat gaa tca ttg aga ttg act ttc cac gat gct att gga atc tca cca   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gct att gct aaa act ggt gtt ttc ggt gga gga ggt gct gat ggt tct   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
att gct att ttc gct gac att gaa act aat ttt cat gct aat aat ggt   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtt gat gaa att att ggt gaa caa gct cca ttc att gct aga cat aat   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ttg act act gct gat ttc att cag ttg gct ggt gct att ggg gtt tct   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aat tgt cca ggt gct cct aga tta aat gtt ttc att ggt aga aaa gat   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gct act caa cca gct cca gat ttg act gtt cca gaa cca ttc gat gat   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtt act aaa att ttg gct aga ttc gaa gat gct ggt aag ttc act cca   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gct gag gtt gtt gct ttg ttg gca agt cat act att gca gcg gca gat   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cat gtt gat cca act att cca gga act cca ttt gac tct act cca gaa   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ttg ttc gat act caa ttc ttc att gaa aca caa ttg cgt gga act tta   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttt cca ggt aat ggt agt aat caa ggt gaa gtt caa tct cct ttg ggt   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
ggg gaa ctt aga ttg cag agt gac ggt ttg tta gca agg gat caa aga   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
act gcg tgt gaa tgg caa tct ttc gtc aat aat caa gct aaa ttg cag   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
tct gct ttc aaa gct gcg ttc gct aga atg act gtt ttg ggt caa aat   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
act aga gct ttg att gat tgt tct gat gtt gtg cct acg cca cct gcc   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
ccg gct tct aaa gct cat ttt cca gcg ggt ttg tct agg agg gac att   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gaa cag gct tgt aga gct act cca ttc cct aca ttg cca acc gat cca   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
ggt cct gtt act act gtt gct cct gtt cca cca agc                   1092
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360
 

<210> 94
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 94
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 95
<211> 1092
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1092)

<400> 95
atg gcg ttt aaa ttg ttg ggt tct ttt gtt tct ttg ttg gcc gcg ttg   48
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                   10                  15
 
cag gtt gcc aac ggt gcc ctt acc cgc cgt gtt acc tgt gcc acg gga   96
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
             20                  25                  30
 
caa gtt acc tct aat gcc gct tgt tgt gct ctt ttt ccg gtc att gat   144
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
         35                  40                  45
 
gac att cag acc aac ttg ttt gat ggt ggt gaa tgt ggt gaa gaa gtt   192
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
     50                  55                  60
 
cat gaa tct ttg cgt ttg acc ttt cat gac gcc att ggc att tct ccg   240
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
 65                  70                  75                  80
 
gct ata gcg aaa act ggt gtt ttt ggt gga gga ggc gca gat ggt tct   288
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                 85                  90                  95
 
att gcc att ttt gcc gac att gaa acc aac ttt cat gct aat aat ggt   336
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110
 
gtt gat gaa att att ggt gaa cag gct ccc ttt att gcc aga cat aat   384
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125
 
ttg acc acc gca gat ttt att cag ttg gct ggt gct ata ggt gtt agt   432
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140
 
aat tgt ccg ggt gct cct cgt ttg aat gtt ttt att ggt cgt aaa gat   480
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160
 
gct acc cag cct gcc cca gat ttg acc gtt ccc gaa cct ttt gat gat   528
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175
 
gtt acc aaa att cta gcc aga ttt gaa gat gct ggt aaa ttt acc cct   576
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190
 
gct gaa gtt gtt gct ctt ttg gcc tct cat acc att gcc gca gct gac   624
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205
 
cat gtt gat ccg acc att ccg ggc aca ccg ttt gat tct acc cca gaa   672
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220
 
ttg ttt gat acc cag ttc ttt att gaa acg cag ttg aga ggt aca ttg   720
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240
 
ttt ccg ggt aat ggt tct aat cag ggt gaa gtt cag tct ccg cta ggt   768
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255
 
gga gaa ttg cgt ctt cag tct gat ggt ttg ttg gct aga gat cag cgt   816
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270
 
acc gca tgt gaa tgg cag tct ttt gtt aat aat cag gct aag ttg cag   864
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285
 
tcc gct ttc aaa gcc gcc ttc gct cgt atg acc gtt ttg ggt cag aat   912
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300
 
acc cgc gca ttg att gat tgt tct gat gtt gtt ccc act cct cct gct   960
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320
 
ccc gct tct aaa gca cat ttt ccg gca ggt ttg tct cgt cgt gac att   1008
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335
 
gaa caa gca tgt cgt gcc acc cct ttc ccc acc ttg cct acc gat cct   1056
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350
 
ggt cct gtt acc act gtt gct cct gtt cct ccg agt                   1092
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360
 

<210> 96
<211> 364
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 96
Met Ala Phe Lys Leu Leu Gly Ser Phe Val Ser Leu Leu Ala Ala Leu
 1               5                  10                  15      
Gln Val Ala Asn Gly Ala Leu Thr Arg Arg Val Thr Cys Ala Thr Gly
            20                  25                  30          
Gln Val Thr Ser Asn Ala Ala Cys Cys Ala Leu Phe Pro Val Ile Asp
        35                  40                  45              
Asp Ile Gln Thr Asn Leu Phe Asp Gly Gly Glu Cys Gly Glu Glu Val
    50                  55                  60                  
His Glu Ser Leu Arg Leu Thr Phe His Asp Ala Ile Gly Ile Ser Pro
65                  70                  75                  80  
Ala Ile Ala Lys Thr Gly Val Phe Gly Gly Gly Gly Ala Asp Gly Ser
                85                  90                  95      
Ile Ala Ile Phe Ala Asp Ile Glu Thr Asn Phe His Ala Asn Asn Gly
            100                 105                 110         
Val Asp Glu Ile Ile Gly Glu Gln Ala Pro Phe Ile Ala Arg His Asn
        115                 120                 125             
Leu Thr Thr Ala Asp Phe Ile Gln Leu Ala Gly Ala Ile Gly Val Ser
    130                 135                 140                 
Asn Cys Pro Gly Ala Pro Arg Leu Asn Val Phe Ile Gly Arg Lys Asp
145                 150                 155                 160 
Ala Thr Gln Pro Ala Pro Asp Leu Thr Val Pro Glu Pro Phe Asp Asp
                165                 170                 175     
Val Thr Lys Ile Leu Ala Arg Phe Glu Asp Ala Gly Lys Phe Thr Pro
            180                 185                 190         
Ala Glu Val Val Ala Leu Leu Ala Ser His Thr Ile Ala Ala Ala Asp
        195                 200                 205             
His Val Asp Pro Thr Ile Pro Gly Thr Pro Phe Asp Ser Thr Pro Glu
    210                 215                 220                 
Leu Phe Asp Thr Gln Phe Phe Ile Glu Thr Gln Leu Arg Gly Thr Leu
225                 230                 235                 240 
Phe Pro Gly Asn Gly Ser Asn Gln Gly Glu Val Gln Ser Pro Leu Gly
                245                 250                 255     
Gly Glu Leu Arg Leu Gln Ser Asp Gly Leu Leu Ala Arg Asp Gln Arg
            260                 265                 270         
Thr Ala Cys Glu Trp Gln Ser Phe Val Asn Asn Gln Ala Lys Leu Gln
        275                 280                 285             
Ser Ala Phe Lys Ala Ala Phe Ala Arg Met Thr Val Leu Gly Gln Asn
    290                 295                 300                 
Thr Arg Ala Leu Ile Asp Cys Ser Asp Val Val Pro Thr Pro Pro Ala
305                 310                 315                 320 
Pro Ala Ser Lys Ala His Phe Pro Ala Gly Leu Ser Arg Arg Asp Ile
                325                 330                 335     
Glu Gln Ala Cys Arg Ala Thr Pro Phe Pro Thr Leu Pro Thr Asp Pro
            340                 345                 350         
Gly Pro Val Thr Thr Val Ala Pro Val Pro Pro Ser
        355                 360                 


<210> 97
<211> 1860
<212> DNA
<213> N. crassa

<220> 
<221> CDS            
<222> (1)...(1860)

<400> 97
atg aaa ttc ttg ggc att gcc gcc ctc gtt gcg ggc ctt ctt gcc cct   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tca ctt gtt ctc ggt gct cct gca cct ggc acc gag gga gtg aat ctc   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
ctc act ccc gtt gat aag aga cag gac tcc caa gcc gaa cgt tat gga   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
ggt ggc gga ggc ggt ggt tgc aac tcc ccg acc aac cgg cag tgt tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
tct cca gga ttc aac atc aac acc gac tat gaa ctc gga act cct aat   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
acc ggc aag acc aga cgg tac aaa ctc acc ctc acc gag act gat aac   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg ctt ggc cct gat ggt gtc ata aag gat aag gtc atg atg gtc aac   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gac aac atc att gga cct acc att cag gct gat tgg ggc gac tat att   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gag atc acc gtc atc aac aaa ctg aag tcg aac ggc acc tcg atc cac   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cat ggc atg cac cag cgc aac tcc aac atc cag gac ggc gtc aac   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
ggc gtt acc gag tgc ccc atc cca ccc aga ggc ggc agc aaa gta tac   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
cgc tgg cgg gcc acc cag tac ggg acg tcg tgg tac cac tcg cat ttc   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tca gcg cag tac ggc aat ggc att gtt ggg ccc att gtt atc aac gga   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
ccg gcc tcg gcc aac tac gac gtg gac ctc ggc cct ttc ccg ctc acg   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gac tac tat tac gac aca gcc gac cgt ctc gtg ctg ctc aca cag cat   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gcc ggc cct ccg ccg agc aac aat gtg ctc ttc aac ggc ttc gcc aag   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cat ccg acc aca ggc gct ggc cag tat gct acc gtg tcg ctc acc aag   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggc aag aag cat cgg ctg cgg ctc atc aac acc tcg gtc gag aac cac   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttc caa ctg tcg ctg gtg aat cac tcc atg acc atc atc tcg gcg gat   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
ctg gtt ccc gtg cag ccc tac aag gtc gac agc ctg ctg ctc ggc atc   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
ggc cag cgc tac gac gtc atc atc gac gcc aac cag gcc gtt ggg aac   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tac tgg ttc aat gtg acg ttt ggt ggc aac gac cta tgc ggt acc tcg   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gac aac aag tac ccg gcc gcc atc ttc cgg tac cag ggc gcg cca aag   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gca ctg ccg acc aac aag ggc gtt gcg ccg cct gac cac caa tgc ctg   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gac ctc aac gac ctg aag ccc gtc ctg cag cgc agc ctg aac acc aac   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
agc atc gca ctc aac act ggc aac acg atc ccc atc acg ctc gac ggg   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttc gtc tgg cgg gtc aat gga acg gcc atc aac atc aac tgg aac aag   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
ccg gtg ctg gag tac gtg atg acg ggc aac acc aac tac tcg cag tcc   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gac aac att gtg cag gtc gag ggc gtc aac caa tgg aag tac tgg ctc   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
atc gag aac gac ccc gat ggt gcc ttt agc ctg ccg cat ccc atc cac   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
ctg cac ggc cac gac ttt ctc atc ctc ggt cgg tcg ccc gac gtg acc   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gcc atc agc cag acg cgc tac gtg ttt gac ccg gcc gtg gac atg gct   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
cgg ttg aac ggc aac aac ccg acg cgg cgc gac acg gcc atg ctc ccg   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gcc aag ggc tgg ctg ctc atc gcg ttc cgc acc gac aat ccc ggc tcg   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg ctg atg cac tgc cac att gcc tgg cac gtc tcg ggg ggt ctg tcg   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aac cag ttc ctg gag cgg gcg cag gac ctc agg aac agt atc agc cct   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gca gat aag aag gcc ttt aac gac aac tgt gac gcg tgg agg gcg tac   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttc cct gac aat gcg ccg ttc ccc aag gac gac tct ggc ctc agg agt   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
ggc gtc aag gca aga gag gtg aag atg aag tgg tag                   1860
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp  *
    610                 615
 

<210> 98
<211> 619
<212> PRT
<213> N. crassa

<400> 98
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 99
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1857)

<400> 99
atg aaa ttt ttg gga att gct gct ttg gtt gct ggt ttg ttg gct cca   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tct ttg gtg tta ggt gct cca gct ccc ggt act gaa ggt gta aat ttg   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
tta act cca gtt gat aaa aga caa gat tca caa gct gaa aga tat ggt   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
ggc ggt ggt ggt ggt ggt tgt aat tct cct act aat aga caa tgt tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
tca cca ggt ttt aat ata aat act gat tat gaa ttg ggt act ccg aat   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
act ggt aaa act aga agg tat aaa ttg aca ttg act gaa act gat aat   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg ttg ggt cca gat ggt gta att aaa gat aaa gta atg atg gtt aat   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gat aat ata att ggt cca act ata caa gct gat tgg ggt gat tat att   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gaa att act gta att aac aaa tta aaa tct aat ggt act tct att cat   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cat ggt atg cat caa aga aat tct aat ata caa gat ggt gtt aat   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
gga gtt act gaa tgt cca att cct cct aga ggt ggt tct aag gtt tat   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
aga tgg cgt gca act caa tac ggt act tcg tgg tat cat tct cat ttt   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tct gca caa tat ggt aat gga att gtt ggt cca att gtt ata aat ggt   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
cca gct tct gct aat tat gat gtt gat ttg ggt cca ttt cca ttg act   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gat tat tat tat gat act gct gat aga ttg gtt ttg tta act caa cat   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gct ggt cct cct cct tct aat aat gtt tta ttt aat ggt ttt gct aaa   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cat cca act act ggt gcg gga caa tat gct aca gtt tca ttg act aaa   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggt aaa aag cat aga ttg aga ttg att aat act tct gtt gag aat cat   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttt caa ttg tct ttg gtt aat cat tct atg act att att tct gct gat   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
ttg gtt cca gtt caa cca tat aaa gta gat tct ttg ttg ttg gga att   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
ggt caa aga tat gat gta att att gat gct aat caa gct gtt ggt aat   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tat tgg ttt aat gtt act ttt gga ggt aat gat ttg tgt ggt act tct   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gat aat aaa tat cca gct gct att ttt aga tat caa ggt gct cca aag   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gct tta cca act aat aaa ggg gtt gct cca cca gat cat caa tgt ttg   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gat tta aat gat tta aaa cct gtt ttg caa aga tct tta aat act aat   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
tct att gct tta aat act ggt aat act att cca att act cta gat ggt   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttt gtc tgg agg gtt aac ggt act gct att aat ata aat tgg aat aaa   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
ccc gtt cta gaa tat gtt atg act ggg aat aca aat tat tca caa tct   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gat aat ata gtt caa gtt gaa ggt gtt aat caa tgg aaa tat tgg ttg   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
att gaa aat gat cca gat ggt gct ttt tct ttg cca cat cca att cac   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
ttg cac ggt cat gac ttt ttg att ttg ggt aga tct cct gat gtt aca   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gct att tca caa act aga tat gtt ttt gat cca gct gtt gat atg gct   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
aga tta aat ggt aat aat cca act aga agg gat act gct atg ttg cca   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gct aaa ggt tgg ttg ttg att gct ttt aga act gat aat cct ggt tct   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg ttg atg cat tgt cat att gct tgg cat gtt tca ggt ggt ttg tct   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aat caa ttt ttg gaa aga gca caa gat ttg aga aat tct att tca cca   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gct gat aaa aag gcg ttt aat gat aat tgt gat gcg tgg aga gct tat   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttt cca gat aat gct cca ttt cca aag gat gat agc ggt ttg aga tct   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
ggt gtt aaa gct aga gaa gtt aaa atg aaa tgg                       1857
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615
 

<210> 100
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 100
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 101
<211> 1885
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1871)

<400> 101
gaatactcca tatg atg aaa ttt ttg gga att gct gct ttg gtt gct ggt   50
                Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly
                 1               5                   10
 
ttg ttg gct cca tct ttg gtg tta ggt gct cca gct ccc ggt act gaa   98
Leu Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu
         15                  20                  25
 
ggt gta aat ttg tta act cca gtt gat aaa aga caa gat tca caa gct   146
Gly Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala
     30                  35                  40
 
gaa aga tat ggt ggc ggt ggt ggt ggt ggt tgt aat tct cct act aat   194
Glu Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn
 45                  50                  55                  60
 
aga caa tgt tgg tca cca ggt ttt aat ata aat act gat tat gaa ttg   242
Arg Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu
                 65                  70                  75
 
ggt act ccg aat act ggt aaa act aga agg tat aaa ttg aca ttg act   290
Gly Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr
             80                  85                  90
 
gaa act gat aat tgg ttg ggt cca gat ggt gta att aaa gat aaa gta   338
Glu Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val
         95                 100                 105
 
atg atg gtt aat gat aat ata att ggt cca act ata caa gct gat tgg   386
Met Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp
    110                 115                 120
 
ggt gat tat att gaa att act gta att aac aaa tta aaa tct aat ggt   434
Gly Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly
125                 130                 135                 140
 
act tct att cat tgg cat ggt atg cat caa aga aat tct aat ata caa   482
Thr Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln
                145                 150                 155
 
gat ggt gtt aat gga gtt act gaa tgt cca att cct cct aga ggt ggt   530
Asp Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly
            160                 165                 170
 
tct aag gtt tat aga tgg cgt gca act caa tac ggt act tcg tgg tat   578
Ser Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr
        175                 180                 185
 
cat tct cat ttt tct gca caa tat ggt aat gga att gtt ggt cca att   626
His Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile
    190                 195                 200
 
gtt ata aat ggt cca gct tct gct aat tat gat gtt gat ttg ggt cca   674
Val Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro
205                 210                 215                 220
 
ttt cca ttg act gat tat tat tat gat act gct gat aga ttg gtt ttg   722
Phe Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu
                225                 230                 235
 
tta act caa cat gct ggt cct cct cct tct aat aat gtt tta ttt aat   770
Leu Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn
            240                 245                 250
 
ggt ttt gct aaa cat cca act act ggt gcg gga caa tat gct aca gtt   818
Gly Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val
        255                 260                 265
 
tca ttg act aaa ggt aaa aag cat aga ttg aga ttg att aat act tct   866
Ser Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser
    270                 275                 280
 
gtt gag aat cat ttt caa ttg tct ttg gtt aat cat tct atg act att   914
Val Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile
285                 290                 295                 300
 
att tct gct gat ttg gtt cca gtt caa cca tat aaa gta gat tct ttg   962
Ile Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu
                305                 310                 315
 
ttg ttg gga att ggt caa aga tat gat gta att att gat gct aat caa   1010
Leu Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln
            320                 325                 330
 
gct gtt ggt aat tat tgg ttt aat gtt act ttt gga ggt aat gat ttg   1058
Ala Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu
        335                 340                 345
 
tgt ggt act tct gat aat aaa tat cca gct gct att ttt aga tat caa   1106
Cys Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln
    350                 355                 360
 
ggt gct cca aag gct tta cca act aat aaa ggg gtt gct cca cca gat   1154
Gly Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp
365                 370                 375                 380
 
cat caa tgt ttg gat tta aat gat tta aaa cct gtt ttg caa aga tct   1202
His Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser
                385                 390                 395
 
tta aat act aat tct att gct tta aat act ggt aat act att cca att   1250
Leu Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile
            400                 405                 410
 
act cta gat ggt ttt gtc tgg agg gtt aac ggt act gct att aat ata   1298
Thr Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile
        415                 420                 425
 
aat tgg aat aaa ccc gtt cta gaa tat gtt atg act ggg aat aca aat   1346
Asn Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn
    430                 435                 440
 
tat tca caa tct gat aat ata gtt caa gtt gaa ggt gtt aat caa tgg   1394
Tyr Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp
445                 450                 455                 460
 
aaa tat tgg ttg att gaa aat gat cca gat ggt gct ttt tct ttg cca   1442
Lys Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro
                465                 470                 475
 
cat cca att cac ttg cac ggt cat gac ttt ttg att ttg ggt aga tct   1490
His Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser
            480                 485                 490
 
cct gat gtt aca gct att tca caa act aga tat gtt ttt gat cca gct   1538
Pro Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala
        495                 500                 505
 
gtt gat atg gct aga tta aat ggt aat aat cca act aga agg gat act   1586
Val Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr
    510                 515                 520
 
gct atg ttg cca gct aaa ggt tgg ttg ttg att gct ttt aga act gat   1634
Ala Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp
525                 530                 535                 540
 
aat cct ggt tct tgg ttg atg cat tgt cat att gct tgg cat gtt tca   1682
Asn Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser
                545                 550                 555
 
ggt ggt ttg tct aat caa ttt ttg gaa aga gca caa gat ttg aga aat   1730
Gly Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn
            560                 565                 570
 
tct att tca cca gct gat aaa aag gcg ttt aat gat aat tgt gat gcg   1778
Ser Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala
        575                 580                 585
 
tgg aga gct tat ttt cca gat aat gct cca ttt cca aag gat gat agc   1826
Trp Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser
    590                 595                 600
 
ggt ttg aga tct ggt gtt aaa gct aga gaa gtt aaa atg aaa tgg       1871
Gly Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
605                 610                 615
 
actagtcagt gcct                                                   1885

<210> 102
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 102
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 103
<211> 1879
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1868)

<400> 103
tactcaagct t atg aaa ttt ttg gga att gct gct ttg gtt gct ggt ttg  50
             Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu
              1               5                   10
 
ttg gct cca tct ttg gtg tta ggt gct cca gct ccc ggt act gaa ggt   98
Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly
     15                  20                  25
 
gta aat ttg tta act cca gtt gat aaa aga caa gat tca caa gct gaa   146
Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu
 30                  35                  40                  45
 
aga tat ggt ggc ggt ggt ggt ggt ggt tgt aat tct cct act aat aga   194
Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg
                 50                  55                  60
 
caa tgt tgg tca cca ggt ttt aat ata aat act gat tat gaa ttg ggt   242
Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly
             65                  70                  75
 
act ccg aat act ggt aaa act aga agg tat aaa ttg aca ttg act gaa   290
Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu
         80                  85                  90
 
act gat aat tgg ttg ggt cca gat ggt gta att aaa gat aaa gta atg   338
Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met
     95                 100                 105
 
atg gtt aat gat aat ata att ggt cca act ata caa gct gat tgg ggt   386
Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly
110                 115                 120                 125
 
gat tat att gaa att act gta att aac aaa tta aaa tct aat ggt act   434
Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr
                130                 135                 140
 
tct att cat tgg cat ggt atg cat caa aga aat tct aat ata caa gat   482
Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp
            145                 150                 155
 
ggt gtt aat gga gtt act gaa tgt cca att cct cct aga ggt ggt tct   530
Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser
        160                 165                 170
 
aag gtt tat aga tgg cgt gca act caa tac ggt act tcg tgg tat cat   578
Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His
    175                 180                 185
 
tct cat ttt tct gca caa tat ggt aat gga att gtt ggt cca att gtt   626
Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val
190                 195                 200                 205
 
ata aat ggt cca gct tct gct aat tat gat gtt gat ttg ggt cca ttt   674
Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe
                210                 215                 220
 
cca ttg act gat tat tat tat gat act gct gat aga ttg gtt ttg tta   722
Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu
            225                 230                 235
 
act caa cat gct ggt cct cct cct tct aat aat gtt tta ttt aat ggt   770
Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly
        240                 245                 250
 
ttt gct aaa cat cca act act ggt gcg gga caa tat gct aca gtt tca   818
Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser
    255                 260                 265
 
ttg act aaa ggt aaa aag cat aga ttg aga ttg att aat act tct gtt   866
Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val
270                 275                 280                 285
 
gag aat cat ttt caa ttg tct ttg gtt aat cat tct atg act att att   914
Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile
                290                 295                 300
 
tct gct gat ttg gtt cca gtt caa cca tat aaa gta gat tct ttg ttg   962
Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu
            305                 310                 315
 
ttg gga att ggt caa aga tat gat gta att att gat gct aat caa gct   1010
Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala
        320                 325                 330
 
gtt ggt aat tat tgg ttt aat gtt act ttt gga ggt aat gat ttg tgt   1058
Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys
    335                 340                 345
 
ggt act tct gat aat aaa tat cca gct gct att ttt aga tat caa ggt   1106
Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly
350                 355                 360                 365
 
gct cca aag gct tta cca act aat aaa ggg gtt gct cca cca gat cat   1154
Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His
                370                 375                 380
 
caa tgt ttg gat tta aat gat tta aaa cct gtt ttg caa aga tct tta   1202
Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu
            385                 390                 395
 
aat act aat tct att gct tta aat act ggt aat act att cca att act   1250
Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr
        400                 405                 410
 
cta gat ggt ttt gtc tgg agg gtt aac ggt act gct att aat ata aat   1298
Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn
    415                 420                 425
 
tgg aat aaa ccc gtt cta gaa tat gtt atg act ggg aat aca aat tat   1346
Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr
430                 435                 440                 445
 
tca caa tct gat aat ata gtt caa gtt gaa ggt gtt aat caa tgg aaa   1394
Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys
                450                 455                 460
 
tat tgg ttg att gaa aat gat cca gat ggt gct ttt tct ttg cca cat   1442
Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His
            465                 470                 475
 
cca att cac ttg cac ggt cat gac ttt ttg att ttg ggt aga tct cct   1490
Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro
        480                 485                 490
 
gat gtt aca gct att tca caa act aga tat gtt ttt gat cca gct gtt   1538
Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val
    495                 500                 505
 
gat atg gct aga tta aat ggt aat aat cca act aga agg gat act gct   1586
Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala
510                 515                 520                 525
 
atg ttg cca gct aaa ggt tgg ttg ttg att gct ttt aga act gat aat   1634
Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn
                530                 535                 540
 
cct ggt tct tgg ttg atg cat tgt cat att gct tgg cat gtt tca ggt   1682
Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly
            545                 550                 555
 
ggt ttg tct aat caa ttt ttg gaa aga gca caa gat ttg aga aat tct   1730
Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser
        560                 565                 570
 
att tca cca gct gat aaa aag gcg ttt aat gat aat tgt gat gcg tgg   1778
Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp
    575                 580                 585
 
aga gct tat ttt cca gat aat gct cca ttt cca aag gat gat agc ggt   1826
Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly
590                 595                 600                 605
 
ttg aga tct ggt gtt aaa gct aga gaa gtt aaa atg aaa tgg           1868
Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
                610                 615
 
gaattccgat g                                                      1879

<210> 104
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 104
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 105
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1857)

<400> 105
atg aaa ttc ctg ggt atc gcg gct ctg gtt gcg ggt ctg ctg gct ccg   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tct ctg gtt ctg ggt gcg ccg gct cca ggt act gag ggt gtt aac ctg   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
ctg acc ccg gtt gac aaa cgt cag gac tct cag gct gag cgt tac ggt   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
ggt ggt ggt ggc ggc ggc tgc aac tct ccg acc aac cgt cag tgc tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
tct ccg ggt ttc aac atc aac acc gac tac gaa ctg ggt act ccg aac   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
acc ggt aaa acc cgt cgt tac aaa ctg acc ctg acc gaa acc gac aat   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg ctg ggt ccg gac ggt gtt atc aaa gac aag gta atg atg gtc aac   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gac aac atc atc ggt ccg acc atc cag gct gat tgg ggt gac tac atc   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gag atc acc gtg atc aac aag ctg aaa tct aac ggc act tct atc cat   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cac ggt atg cac cag cgt aac tct aac atc cag gac ggt gtt aac   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
ggt gtt acc gaa tgc ccg atc ccg ccg cgt ggt ggt tct aaa gtt tac   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
cgt tgg cgt gcg acc cag tac ggt act tct tgg tat cac tct cac ttc   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tct gcg cag tac ggt aac ggt atc gtt ggt ccg atc gtt atc aac ggt   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
ccg gcg tct gcg aac tac gac gtt gac ctg ggt ccg ttc cca ctg acc   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gac tac tac tac gac acc gct gat cgt ctg gtt ctg ctg acc cag cac   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gcg ggt ccg ccg ccg tct aac aac gtt ctg ttc aac ggt ttc gcg aaa   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cac ccg acc acc ggt gcg ggt cag tac gcg acc gtt agc ctg acc aaa   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggt aaa aag cac cgt ctg cgt ctg atc aac acc tcg gtt gaa aac cac   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttt cag ctg agc ctg gtt aac cac tct atg acc atc atc tct gcg gac   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
ctg gtt ccg gtt cag ccg tac aaa gtt gac tct ctg ctg ctg ggt atc   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
ggt cag cgt tac gac gtt atc att gac gcg aat cag gct gtt ggc aac   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tat tgg ttc aac gtc acg ttc ggt ggt aac gac ctg tgc ggc act tcg   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gac aac aaa tac ccg gct gcg atc ttt cgt tac cag ggt gcg ccg aaa   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gct ctg ccg acc aac aaa ggt gtt gcg ccg ccg gac cac cag tgc ctg   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gac ctg aac gac ctg aaa ccg gtt ctc cag cgt tct ctg aac acc aac   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
tct atc gcg ttg aac acc ggt aac acc atc ccg atc acc ctg gac ggt   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttc gtt tgg cgt gtt aac ggc acc gcg atc aac atc aat tgg aac aaa   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
ccg gtc ctc gaa tac gtt atg acc ggt aac act aac tac tct cag tct   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gac aac atc gtt cag gtt gaa ggc gtt aac cag tgg aaa tat tgg ctg   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
atc gaa aac gac ccg gac ggt gcg ttc tct ctg ccg cac ccg atc cac   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
ctg cac ggt cac gac ttc ctg atc ctg ggt cgt tct ccg gac gtt acc   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gcg atc tct cag acc cgt tac gtt ttc gac ccg gcg gtt gac atg gct   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
cgt ctg aac ggt aac aac ccg acc cgt cgt gac acc gct atg ctg ccg   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gcg aaa ggt tgg ctg ctg atc gcg ttt cgt acc gac aac ccg ggt tct   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg ctg atg cac tgc cac atc gcg tgg cac gtt agc ggt ggt ctg tct   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aac cag ttc ttg gaa cgt gcg cag gac ctg cgt aac tct atc tct ccg   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gcg gac aaa aag gcg ttc aac gac aac tgc gac gcg tgg cgt gcg tac   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttc cca gac aac gcg ccg ttc cca aaa gac gac tct ggt ctg cgt tct   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
ggt gtc aaa gct cgt gaa gtt aaa atg aaa tgg                       1857
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615
 

<210> 106
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 106
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 107
<211> 1879
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1868)

<400> 107
tactcaagct t atg aaa ttc ctg ggt atc gcg gct ctg gtt gcg ggt ctg  50
             Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu
              1               5                   10
 
ctg gct ccg tct ctg gtt ctg ggt gcg ccg gct cca ggt act gag ggt   98
Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly
     15                  20                  25
 
gtt aac ctg ctg acc ccg gtt gac aaa cgt cag gac tct cag gct gag   146
Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu
 30                  35                  40                  45
 
cgt tac ggt ggt ggt ggt ggc ggc ggc tgc aac tct ccg acc aac cgt   194
Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg
                 50                  55                  60
 
cag tgc tgg tct ccg ggt ttc aac atc aac acc gac tac gaa ctg ggt   242
Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly
             65                  70                  75
 
act ccg aac acc ggt aaa acc cgt cgt tac aaa ctg acc ctg acc gaa   290
Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu
         80                  85                  90
 
acc gac aat tgg ctg ggt ccg gac ggt gtt atc aaa gac aag gta atg   338
Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met
     95                 100                 105
 
atg gtc aac gac aac atc atc ggt ccg acc atc cag gct gat tgg ggt   386
Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly
110                 115                 120                 125
 
gac tac atc gag atc acc gtg atc aac aag ctg aaa tct aac ggc act   434
Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr
                130                 135                 140
 
tct atc cat tgg cac ggt atg cac cag cgt aac tct aac atc cag gac   482
Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp
            145                 150                 155
 
ggt gtt aac ggt gtt acc gaa tgc ccg atc ccg ccg cgt ggt ggt tct   530
Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser
        160                 165                 170
 
aaa gtt tac cgt tgg cgt gcg acc cag tac ggt act tct tgg tat cac   578
Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His
    175                 180                 185
 
tct cac ttc tct gcg cag tac ggt aac ggt atc gtt ggt ccg atc gtt   626
Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val
190                 195                 200                 205
 
atc aac ggt ccg gcg tct gcg aac tac gac gtt gac ctg ggt ccg ttc   674
Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe
                210                 215                 220
 
cca ctg acc gac tac tac tac gac acc gct gat cgt ctg gtt ctg ctg   722
Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu
            225                 230                 235
 
acc cag cac gcg ggt ccg ccg ccg tct aac aac gtt ctg ttc aac ggt   770
Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly
        240                 245                 250
 
ttc gcg aaa cac ccg acc acc ggt gcg ggt cag tac gcg acc gtt agc   818
Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser
    255                 260                 265
 
ctg acc aaa ggt aaa aag cac cgt ctg cgt ctg atc aac acc tcg gtt   866
Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val
270                 275                 280                 285
 
gaa aac cac ttt cag ctg agc ctg gtt aac cac tct atg acc atc atc   914
Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile
                290                 295                 300
 
tct gcg gac ctg gtt ccg gtt cag ccg tac aaa gtt gac tct ctg ctg   962
Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu
            305                 310                 315
 
ctg ggt atc ggt cag cgt tac gac gtt atc att gac gcg aat cag gct   1010
Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala
        320                 325                 330
 
gtt ggc aac tat tgg ttc aac gtc acg ttc ggt ggt aac gac ctg tgc   1058
Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys
    335                 340                 345
 
ggc act tcg gac aac aaa tac ccg gct gcg atc ttt cgt tac cag ggt   1106
Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly
350                 355                 360                 365
 
gcg ccg aaa gct ctg ccg acc aac aaa ggt gtt gcg ccg ccg gac cac   1154
Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His
                370                 375                 380
 
cag tgc ctg gac ctg aac gac ctg aaa ccg gtt ctc cag cgt tct ctg   1202
Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu
            385                 390                 395
 
aac acc aac tct atc gcg ttg aac acc ggt aac acc atc ccg atc acc   1250
Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr
        400                 405                 410
 
ctg gac ggt ttc gtt tgg cgt gtt aac ggc acc gcg atc aac atc aat   1298
Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn
    415                 420                 425
 
tgg aac aaa ccg gtc ctc gaa tac gtt atg acc ggt aac act aac tac   1346
Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr
430                 435                 440                 445
 
tct cag tct gac aac atc gtt cag gtt gaa ggc gtt aac cag tgg aaa   1394
Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys
                450                 455                 460
 
tat tgg ctg atc gaa aac gac ccg gac ggt gcg ttc tct ctg ccg cac   1442
Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His
            465                 470                 475
 
ccg atc cac ctg cac ggt cac gac ttc ctg atc ctg ggt cgt tct ccg   1490
Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro
        480                 485                 490
 
gac gtt acc gcg atc tct cag acc cgt tac gtt ttc gac ccg gcg gtt   1538
Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val
    495                 500                 505
 
gac atg gct cgt ctg aac ggt aac aac ccg acc cgt cgt gac acc gct   1586
Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala
510                 515                 520                 525
 
atg ctg ccg gcg aaa ggt tgg ctg ctg atc gcg ttt cgt acc gac aac   1634
Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn
                530                 535                 540
 
ccg ggt tct tgg ctg atg cac tgc cac atc gcg tgg cac gtt agc ggt   1682
Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly
            545                 550                 555
 
ggt ctg tct aac cag ttc ttg gaa cgt gcg cag gac ctg cgt aac tct   1730
Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser
        560                 565                 570
 
atc tct ccg gcg gac aaa aag gcg ttc aac gac aac tgc gac gcg tgg   1778
Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp
    575                 580                 585
 
cgt gcg tac ttc cca gac aac gcg ccg ttc cca aaa gac gac tct ggt   1826
Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly
590                 595                 600                 605
 
ctg cgt tct ggt gtc aaa gct cgt gaa gtt aaa atg aaa tgg           1868
Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
                610                 615
 
gaattccgat g                                                      1879

<210> 108
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 108
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 109
<211> 1885
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1871)

<400> 109
gaatactcca tatg atg aaa ttc ctg ggt atc gcg gct ctg gtt gcg ggt   50
                Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly
                 1               5                   10
 
ctg ctg gct ccg tct ctg gtt ctg ggt gcg ccg gct cca ggt act gag   98
Leu Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu
         15                  20                  25
 
ggt gtt aac ctg ctg acc ccg gtt gac aaa cgt cag gac tct cag gct   146
Gly Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala
     30                  35                  40
 
gag cgt tac ggt ggt ggt ggt ggc ggc ggc tgc aac tct ccg acc aac   194
Glu Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn
 45                  50                  55                  60
 
cgt cag tgc tgg tct ccg ggt ttc aac atc aac acc gac tac gaa ctg   242
Arg Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu
                 65                  70                  75
 
ggt act ccg aac acc ggt aaa acc cgt cgt tac aaa ctg acc ctg acc   290
Gly Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr
             80                  85                  90
 
gaa acc gac aat tgg ctg ggt ccg gac ggt gtt atc aaa gac aag gta   338
Glu Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val
         95                 100                 105
 
atg atg gtc aac gac aac atc atc ggt ccg acc atc cag gct gat tgg   386
Met Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp
    110                 115                 120
 
ggt gac tac atc gag atc acc gtg atc aac aag ctg aaa tct aac ggc   434
Gly Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly
125                 130                 135                 140
 
act tct atc cat tgg cac ggt atg cac cag cgt aac tct aac atc cag   482
Thr Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln
                145                 150                 155
 
gac ggt gtt aac ggt gtt acc gaa tgc ccg atc ccg ccg cgt ggt ggt   530
Asp Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly
            160                 165                 170
 
tct aaa gtt tac cgt tgg cgt gcg acc cag tac ggt act tct tgg tat   578
Ser Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr
        175                 180                 185
 
cac tct cac ttc tct gcg cag tac ggt aac ggt atc gtt ggt ccg atc   626
His Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile
    190                 195                 200
 
gtt atc aac ggt ccg gcg tct gcg aac tac gac gtt gac ctg ggt ccg   674
Val Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro
205                 210                 215                 220
 
ttc cca ctg acc gac tac tac tac gac acc gct gat cgt ctg gtt ctg   722
Phe Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu
                225                 230                 235
 
ctg acc cag cac gcg ggt ccg ccg ccg tct aac aac gtt ctg ttc aac   770
Leu Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn
            240                 245                 250
 
ggt ttc gcg aaa cac ccg acc acc ggt gcg ggt cag tac gcg acc gtt   818
Gly Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val
        255                 260                 265
 
agc ctg acc aaa ggt aaa aag cac cgt ctg cgt ctg atc aac acc tcg   866
Ser Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser
    270                 275                 280
 
gtt gaa aac cac ttt cag ctg agc ctg gtt aac cac tct atg acc atc   914
Val Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile
285                 290                 295                 300
 
atc tct gcg gac ctg gtt ccg gtt cag ccg tac aaa gtt gac tct ctg   962
Ile Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu
                305                 310                 315
 
ctg ctg ggt atc ggt cag cgt tac gac gtt atc att gac gcg aat cag   1010
Leu Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln
            320                 325                 330
 
gct gtt ggc aac tat tgg ttc aac gtc acg ttc ggt ggt aac gac ctg   1058
Ala Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu
        335                 340                 345
 
tgc ggc act tcg gac aac aaa tac ccg gct gcg atc ttt cgt tac cag   1106
Cys Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln
    350                 355                 360
 
ggt gcg ccg aaa gct ctg ccg acc aac aaa ggt gtt gcg ccg ccg gac   1154
Gly Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp
365                 370                 375                 380
 
cac cag tgc ctg gac ctg aac gac ctg aaa ccg gtt ctc cag cgt tct   1202
His Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser
                385                 390                 395
 
ctg aac acc aac tct atc gcg ttg aac acc ggt aac acc atc ccg atc   1250
Leu Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile
            400                 405                 410
 
acc ctg gac ggt ttc gtt tgg cgt gtt aac ggc acc gcg atc aac atc   1298
Thr Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile
        415                 420                 425
 
aat tgg aac aaa ccg gtc ctc gaa tac gtt atg acc ggt aac act aac   1346
Asn Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn
    430                 435                 440
 
tac tct cag tct gac aac atc gtt cag gtt gaa ggc gtt aac cag tgg   1394
Tyr Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp
445                 450                 455                 460
 
aaa tat tgg ctg atc gaa aac gac ccg gac ggt gcg ttc tct ctg ccg   1442
Lys Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro
                465                 470                 475
 
cac ccg atc cac ctg cac ggt cac gac ttc ctg atc ctg ggt cgt tct   1490
His Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser
            480                 485                 490
 
ccg gac gtt acc gcg atc tct cag acc cgt tac gtt ttc gac ccg gcg   1538
Pro Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala
        495                 500                 505
 
gtt gac atg gct cgt ctg aac ggt aac aac ccg acc cgt cgt gac acc   1586
Val Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr
    510                 515                 520
 
gct atg ctg ccg gcg aaa ggt tgg ctg ctg atc gcg ttt cgt acc gac   1634
Ala Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp
525                 530                 535                 540
 
aac ccg ggt tct tgg ctg atg cac tgc cac atc gcg tgg cac gtt agc   1682
Asn Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser
                545                 550                 555
 
ggt ggt ctg tct aac cag ttc ttg gaa cgt gcg cag gac ctg cgt aac   1730
Gly Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn
            560                 565                 570
 
tct atc tct ccg gcg gac aaa aag gcg ttc aac gac aac tgc gac gcg   1778
Ser Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala
        575                 580                 585
 
tgg cgt gcg tac ttc cca gac aac gcg ccg ttc cca aaa gac gac tct   1826
Trp Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser
    590                 595                 600
 
ggt ctg cgt tct ggt gtc aaa gct cgt gaa gtt aaa atg aaa tgg       1871
Gly Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
605                 610                 615
 
actagtcagt gcct                                                   1885

<210> 110
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 110
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 111
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1857)

<400> 111
atg aaa ttt ttg gga atc gca gct ttg gtt gca gga ttg ttg gcc cca   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tct tta gtt cta ggt gct cct gct ccc ggt act gag ggt gtt aat tta   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
ttg act cct gtt gat aaa aga caa gat tct caa gct gaa aga tac gga   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
ggt ggc gga ggt gga gga tgt aat tca ccc aca aat aga caa tgt tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
tct cca gga ttt aac att aat act gat tat gaa ttg gga aca cct aat   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
act gga aaa act aga aga tat aaa ttg aca ttg act gaa act gat aat   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg ttg ggt ccc gat gga gtt att aaa gat aaa gtt atg atg gtt aat   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gat aat ata att gga cct act atc cag gct gat tgg gga gat tat att   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gaa att act gtt att aat aaa tta aaa tct aac gga aca tct att cat   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cac gga atg cat caa aga aat tct aac att caa gat gga gtt aac   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
gga gtt aca gaa tgt cca att cca cct aga gga gga tct aaa gtt tat   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
aga tgg cga gct act caa tat ggt act tct tgg tat cat tct cat ttt   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tct gca cag tat ggt aat gga att gtt gga cca att gtt att aac gga   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
cct gca tct gct aat tat gat gtt gat ttg gga cca ttt cca ttg act   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gat tat tat tat gat act gct gat aga ttg gtt tta ttg act caa cac   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gca gga cca cca cct tct aac aat gtt tta ttt aat gga ttc gct aaa   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cat cct act act gga gct gga caa tat gct act gtt tca ttg act aaa   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggt aaa aag cat aga ttg aga ttg att aat act tct gtt gag aat cat   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttt caa ttg tct tta gtt aat cat tct atg act att att tct gct gat   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
tta gtt cca gtt caa cca tat aaa gtt gat tca ttg ttg ttg gga att   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
gga caa aga tat gat gtt att att gac gct aat cag gct gtt gga aat   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tat tgg ttt aat gtt act ttt ggc gga aat gat ttg tgt ggt act tct   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gat aat aaa tat cca gct gca att ttt aga tat caa gga gca cct aaa   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gca ttg cct act aac aaa ggt gtg gct cct cct gat cat caa tgt ttg   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gat tta aat gat ttg aag cca gtt ttg caa agg tct tta aat act aat   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
tct att gct tta aac aca ggt aat act att cca att act tta gat gga   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttt gtt tgg agg gtt aat gga aca gct att aac att aat tgg aac aaa   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
cct gta ctc gaa tat gtt atg act gga aat act aat tat tct caa tct   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gat aat ata gtt caa gtt gaa gga gtt aat caa tgg aaa tat tgg ttg   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
att gaa aat gat cct gat ggt gct ttt tca ttg cca cat cct att cat   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
ttg cac gga cat gac ttt ttg att ttg ggt aga tct cca gac gtt act   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gct att tct caa act aga tat gtt ttt gat cca gct gtt gat atg gca   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
aga tta aat gga aat aat cct act aga aga gat act gca atg ttg cca   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gct aaa gga tgg ttg ttg att gct ttt aga act gat aat cct gga tct   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg tta atg cat tgt cat att gct tgg cat gtt tct gga gga ttg tct   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aat caa ttt tta gaa aga gca caa gat ttg aga aat tct atc tct cca   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gct gat aaa aag gct ttc aat gat aac tgt gat gca tgg aga gct tat   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttt cca gat aac gct cca ttt cca aaa gat gat tct gga ttg aga tct   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
gga gtt aaa gct aga gaa gtt aaa atg aag tgg                       1857
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615
 

<210> 112
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 112
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 113
<211> 1885
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1871)

<400> 113
gaatactcca tatg atg aaa ttt ttg gga atc gca gct ttg gtt gca gga   50
                Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly
                 1               5                   10
 
ttg ttg gcc cca tct tta gtt cta ggt gct cct gct ccc ggt act gag   98
Leu Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu
         15                  20                  25
 
ggt gtt aat tta ttg act cct gtt gat aaa aga caa gat tct caa gct   146
Gly Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala
     30                  35                  40
 
gaa aga tac gga ggt ggc gga ggt gga gga tgt aat tca ccc aca aat   194
Glu Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn
 45                  50                  55                  60
 
aga caa tgt tgg tct cca gga ttt aac att aat act gat tat gaa ttg   242
Arg Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu
                 65                  70                  75
 
gga aca cct aat act gga aaa act aga aga tat aaa ttg aca ttg act   290
Gly Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr
             80                  85                  90
 
gaa act gat aat tgg ttg ggt ccc gat gga gtt att aaa gat aaa gtt   338
Glu Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val
         95                 100                 105
 
atg atg gtt aat gat aat ata att gga cct act atc cag gct gat tgg   386
Met Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp
    110                 115                 120
 
gga gat tat att gaa att act gtt att aat aaa tta aaa tct aac gga   434
Gly Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly
125                 130                 135                 140
 
aca tct att cat tgg cac gga atg cat caa aga aat tct aac att caa   482
Thr Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln
                145                 150                 155
 
gat gga gtt aac gga gtt aca gaa tgt cca att cca cct aga gga gga   530
Asp Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly
            160                 165                 170
 
tct aaa gtt tat aga tgg cga gct act caa tat ggt act tct tgg tat   578
Ser Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr
        175                 180                 185
 
cat tct cat ttt tct gca cag tat ggt aat gga att gtt gga cca att   626
His Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile
    190                 195                 200
 
gtt att aac gga cct gca tct gct aat tat gat gtt gat ttg gga cca   674
Val Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro
205                 210                 215                 220
 
ttt cca ttg act gat tat tat tat gat act gct gat aga ttg gtt tta   722
Phe Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu
                225                 230                 235
 
ttg act caa cac gca gga cca cca cct tct aac aat gtt tta ttt aat   770
Leu Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn
            240                 245                 250
 
gga ttc gct aaa cat cct act act gga gct gga caa tat gct act gtt   818
Gly Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val
        255                 260                 265
 
tca ttg act aaa ggt aaa aag cat aga ttg aga ttg att aat act tct   866
Ser Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser
    270                 275                 280
 
gtt gag aat cat ttt caa ttg tct tta gtt aat cat tct atg act att   914
Val Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile
285                 290                 295                 300
 
att tct gct gat tta gtt cca gtt caa cca tat aaa gtt gat tca ttg   962
Ile Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu
                305                 310                 315
 
ttg ttg gga att gga caa aga tat gat gtt att att gac gct aat cag   1010
Leu Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln
            320                 325                 330
 
gct gtt gga aat tat tgg ttt aat gtt act ttt ggc gga aat gat ttg   1058
Ala Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu
        335                 340                 345
 
tgt ggt act tct gat aat aaa tat cca gct gca att ttt aga tat caa   1106
Cys Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln
    350                 355                 360
 
gga gca cct aaa gca ttg cct act aac aaa ggt gtg gct cct cct gat   1154
Gly Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp
365                 370                 375                 380
 
cat caa tgt ttg gat tta aat gat ttg aag cca gtt ttg caa agg tct   1202
His Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser
                385                 390                 395
 
tta aat act aat tct att gct tta aac aca ggt aat act att cca att   1250
Leu Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile
            400                 405                 410
 
act tta gat gga ttt gtt tgg agg gtt aat gga aca gct att aac att   1298
Thr Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile
        415                 420                 425
 
aat tgg aac aaa cct gta ctc gaa tat gtt atg act gga aat act aat   1346
Asn Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn
    430                 435                 440
 
tat tct caa tct gat aat ata gtt caa gtt gaa gga gtt aat caa tgg   1394
Tyr Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp
445                 450                 455                 460
 
aaa tat tgg ttg att gaa aat gat cct gat ggt gct ttt tca ttg cca   1442
Lys Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro
                465                 470                 475
 
cat cct att cat ttg cac gga cat gac ttt ttg att ttg ggt aga tct   1490
His Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser
            480                 485                 490
 
cca gac gtt act gct att tct caa act aga tat gtt ttt gat cca gct   1538
Pro Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala
        495                 500                 505
 
gtt gat atg gca aga tta aat gga aat aat cct act aga aga gat act   1586
Val Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr
    510                 515                 520
 
gca atg ttg cca gct aaa gga tgg ttg ttg att gct ttt aga act gat   1634
Ala Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp
525                 530                 535                 540
 
aat cct gga tct tgg tta atg cat tgt cat att gct tgg cat gtt tct   1682
Asn Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser
                545                 550                 555
 
gga gga ttg tct aat caa ttt tta gaa aga gca caa gat ttg aga aat   1730
Gly Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn
            560                 565                 570
 
tct atc tct cca gct gat aaa aag gct ttc aat gat aac tgt gat gca   1778
Ser Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala
        575                 580                 585
 
tgg aga gct tat ttt cca gat aac gct cca ttt cca aaa gat gat tct   1826
Trp Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser
    590                 595                 600
 
gga ttg aga tct gga gtt aaa gct aga gaa gtt aaa atg aag tgg       1871
Gly Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
605                 610                 615
 
actagtcagt gcct                                                   1885

<210> 114
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 114
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 115
<211> 1879
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1868)

<400> 115
tactcaagct t atg aaa ttt ttg gga atc gca gct ttg gtt gca gga ttg  50
             Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu
              1               5                   10
 
ttg gcc cca tct tta gtt cta ggt gct cct gct ccc ggt act gag ggt   98
Leu Ala Pro Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly
     15                  20                  25
 
gtt aat tta ttg act cct gtt gat aaa aga caa gat tct caa gct gaa   146
Val Asn Leu Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu
 30                  35                  40                  45
 
aga tac gga ggt ggc gga ggt gga gga tgt aat tca ccc aca aat aga   194
Arg Tyr Gly Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg
                 50                  55                  60
 
caa tgt tgg tct cca gga ttt aac att aat act gat tat gaa ttg gga   242
Gln Cys Trp Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly
             65                  70                  75
 
aca cct aat act gga aaa act aga aga tat aaa ttg aca ttg act gaa   290
Thr Pro Asn Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu
         80                  85                  90
 
act gat aat tgg ttg ggt ccc gat gga gtt att aaa gat aaa gtt atg   338
Thr Asp Asn Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met
     95                 100                 105
 
atg gtt aat gat aat ata att gga cct act atc cag gct gat tgg gga   386
Met Val Asn Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly
110                 115                 120                 125
 
gat tat att gaa att act gtt att aat aaa tta aaa tct aac gga aca   434
Asp Tyr Ile Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr
                130                 135                 140
 
tct att cat tgg cac gga atg cat caa aga aat tct aac att caa gat   482
Ser Ile His Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp
            145                 150                 155
 
gga gtt aac gga gtt aca gaa tgt cca att cca cct aga gga gga tct   530
Gly Val Asn Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser
        160                 165                 170
 
aaa gtt tat aga tgg cga gct act caa tat ggt act tct tgg tat cat   578
Lys Val Tyr Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His
    175                 180                 185
 
tct cat ttt tct gca cag tat ggt aat gga att gtt gga cca att gtt   626
Ser His Phe Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val
190                 195                 200                 205
 
att aac gga cct gca tct gct aat tat gat gtt gat ttg gga cca ttt   674
Ile Asn Gly Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe
                210                 215                 220
 
cca ttg act gat tat tat tat gat act gct gat aga ttg gtt tta ttg   722
Pro Leu Thr Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu
            225                 230                 235
 
act caa cac gca gga cca cca cct tct aac aat gtt tta ttt aat gga   770
Thr Gln His Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly
        240                 245                 250
 
ttc gct aaa cat cct act act gga gct gga caa tat gct act gtt tca   818
Phe Ala Lys His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser
    255                 260                 265
 
ttg act aaa ggt aaa aag cat aga ttg aga ttg att aat act tct gtt   866
Leu Thr Lys Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val
270                 275                 280                 285
 
gag aat cat ttt caa ttg tct tta gtt aat cat tct atg act att att   914
Glu Asn His Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile
                290                 295                 300
 
tct gct gat tta gtt cca gtt caa cca tat aaa gtt gat tca ttg ttg   962
Ser Ala Asp Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu
            305                 310                 315
 
ttg gga att gga caa aga tat gat gtt att att gac gct aat cag gct   1010
Leu Gly Ile Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala
        320                 325                 330
 
gtt gga aat tat tgg ttt aat gtt act ttt ggc gga aat gat ttg tgt   1058
Val Gly Asn Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys
    335                 340                 345
 
ggt act tct gat aat aaa tat cca gct gca att ttt aga tat caa gga   1106
Gly Thr Ser Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly
350                 355                 360                 365
 
gca cct aaa gca ttg cct act aac aaa ggt gtg gct cct cct gat cat   1154
Ala Pro Lys Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His
                370                 375                 380
 
caa tgt ttg gat tta aat gat ttg aag cca gtt ttg caa agg tct tta   1202
Gln Cys Leu Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu
            385                 390                 395
 
aat act aat tct att gct tta aac aca ggt aat act att cca att act   1250
Asn Thr Asn Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr
        400                 405                 410
 
tta gat gga ttt gtt tgg agg gtt aat gga aca gct att aac att aat   1298
Leu Asp Gly Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn
    415                 420                 425
 
tgg aac aaa cct gta ctc gaa tat gtt atg act gga aat act aat tat   1346
Trp Asn Lys Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr
430                 435                 440                 445
 
tct caa tct gat aat ata gtt caa gtt gaa gga gtt aat caa tgg aaa   1394
Ser Gln Ser Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys
                450                 455                 460
 
tat tgg ttg att gaa aat gat cct gat ggt gct ttt tca ttg cca cat   1442
Tyr Trp Leu Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His
            465                 470                 475
 
cct att cat ttg cac gga cat gac ttt ttg att ttg ggt aga tct cca   1490
Pro Ile His Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro
        480                 485                 490
 
gac gtt act gct att tct caa act aga tat gtt ttt gat cca gct gtt   1538
Asp Val Thr Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val
    495                 500                 505
 
gat atg gca aga tta aat gga aat aat cct act aga aga gat act gca   1586
Asp Met Ala Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala
510                 515                 520                 525
 
atg ttg cca gct aaa gga tgg ttg ttg att gct ttt aga act gat aat   1634
Met Leu Pro Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn
                530                 535                 540
 
cct gga tct tgg tta atg cat tgt cat att gct tgg cat gtt tct gga   1682
Pro Gly Ser Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly
            545                 550                 555
 
gga ttg tct aat caa ttt tta gaa aga gca caa gat ttg aga aat tct   1730
Gly Leu Ser Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser
        560                 565                 570
 
atc tct cca gct gat aaa aag gct ttc aat gat aac tgt gat gca tgg   1778
Ile Ser Pro Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp
    575                 580                 585
 
aga gct tat ttt cca gat aac gct cca ttt cca aaa gat gat tct gga   1826
Arg Ala Tyr Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly
590                 595                 600                 605
 
ttg aga tct gga gtt aaa gct aga gaa gtt aaa atg aag tgg           1868
Leu Arg Ser Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
                610                 615
 
gaattccgat g                                                      1879

<210> 116
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 116
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 117
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. Lactis

<220> 
<221> CDS            
<222> (1)...(1857)

<400> 117
atg aaa ttc ttg gga atc gct gct ttg gtt gct ggt ttg ttg gct cca   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tca ttg gtt tta ggg gct cca gct cca ggt aca gaa ggt gtt aat ttg   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
ttg aca cct gtg gac aaa agg caa gat tct caa gct gaa aga tat gga   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
gga gga ggt ggt gga gga tgt aat tca cct aca aat aga caa tgt tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
agt cca ggc ttc aac ata aat acc gat tat gaa ttg gga aca cca aat   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
act gga aag act agg aga tat aaa ttg aca ttg act gaa act gat aat   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg tta ggc cct gat ggt gtg att aaa gac aag gtt atg atg gtt aat   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gac aat att att ggt cca act atc caa gca gat tgg ggt gat tac ata   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gag ata aca gtg att aat aag cta aag agt aat ggt aca tct att cat   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cat ggt atg cac cag cgt aat tct aat ata caa gat gga gta aat   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
ggt gtt act gaa tgt cct att cca cca agg gga gga agt aag gtt tat   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
aga tgg aga gct act caa tat gga aca agt tgg tat cat tct cat ttt   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tct gct caa tac ggt aat ggt ata gtt ggt cct att gtt att aat ggt   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
cct gca agt gct aat tat gat gtt gat ttg gga ccg ttt cct ttg aca   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gat tat tat tat gat acc gct gac aga ttg gtt tta ttg aca caa cat   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gcc gga cct ccg ccg agt aat aat gtt ttg ttc aat ggt ttc gct aaa   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cat cca act acg ggt gca ggc cag tat gct act gtt agt tta act aaa   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggc aaa aag cac aga ttg aga ttg att aat act tct gtt gaa aat cat   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttt cag ttg tca ttg gtt aat cat tct atg act att att tct gcg gac   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
tta gta cca gtt caa cca tat aaa gtt gat tca ttg ttg ttg gga att   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
gga cag aga tat gat gtt att att gat gct aat caa gca gtt ggt aat   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tat tgg ttc aat gtt act ttc ggt ggt aat gat ttg tgt gga act tct   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gat aat aaa tat cca gca gct att ttc aga tat caa ggc gca ccg aag   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gct ttg cca act aat aaa gga gtg gca cca cca gac cac cag tgt tta   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gat tta aac gat tta aag cca gtt tta cag aga tcc cta aat act aat   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
tct att gct ctg aac aca gga aat act att cca att act tta gat ggt   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttt gta tgg aga gtt aat gga acc gca atc aac att aac tgg aat aaa   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
ccg gtc ttg gaa tat gtt atg act ggt aac act aat tat tct cag agt   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gac aat att gtt caa gtt gaa gga gtt aac cag tgg aaa tat tgg ctg   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
atc gaa aat gat cca gac ggg gca ttc tca ctg cct cat cca att cat   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
tta cat ggg cat gat ttc ttg att ttg gga agg tca cct gac gtg act   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gct att tct caa act aga tat gtt ttc gat cct gct gta gac atg gct   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
aga tta aat ggt aat aat cca act agg aga gat aca gct atg tta cct   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gct aaa ggt tgg ttg ttg atc gct ttc aga act gat aat cct ggt tct   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg ttg atg cac tgt cat att gct tgg cat gtg agt gga gga ctt agt   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aat caa ttc ttg gaa aga gca cag gac ttg aga aat tct att tca ccg   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gct gac aaa aag gct ttc aat gat aat tgt gat gca tgg agg gct tat   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttt cca gat aat gct cca ttt cca aaa gat gat tct ggt tta aga tct   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
ggc gtt aaa gct aga gaa gtt aaa atg aag tgg                       1857
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615
 

<210> 118
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 118
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 119
<211> 1857
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1857)

<400> 119
atg aaa ttt ttg ggc att gcc gct ctt gtt gcc ggg ttg ttg gct ccc   48
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                   10                  15
 
tct ttg gtt ttg ggt gcc cct gcc cct ggt acg gaa ggt gtt aat ttg   96
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
             20                  25                  30
 
ttg acc cct gtt gat aaa cgt cag gat tct cag gcc gaa cgt tat ggc   144
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
         35                  40                  45
 
ggt gga gga gga ggt ggc tgt aat tct ccg act aat cgt caa tgt tgg   192
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
     50                  55                  60
 
tct cct ggc ttc aac atc aac acg gat tat gaa ttg ggt act ccg aat   240
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
 65                  70                  75                  80
 
acc ggt aaa acc cgc cgt tat aaa ttg acc ttg acc gaa act gat aat   288
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                 85                  90                  95
 
tgg tta ggt ccg gat ggt gtt atc aag gat aaa gtt atg atg gtt aac   336
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110
 
gat aat att att ggt cct aca att cag gct gat tgg ggt gat tat atc   384
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125
 
gaa att acc gtc att aac aaa ctt aaa tct aat ggt acg tct att cat   432
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140
 
tgg cat ggt atg cat cag cgc aat tct aat att cag gat ggt gtt aat   480
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160
 
ggt gtt acc gaa tgt ccg ata cct cca cgc ggc ggc agt aaa gtt tat   528
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175
 
cgt tgg cgt gcc act cag tat ggt act agc tgg tat cat tct cat ttt   576
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190
 
tct gca cag tat gga aat ggc atc gtt ggt ccg att gtc att aat ggt   624
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205
 
ccg gcc tct gcc aac tat gat gtt gat ttg ggt ccg ttt ccg tta acc   672
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220
 
gac tat tat tat gac acc gcc gat cgt ttg gtt ttg ttg acg cag cat   720
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240
 
gca ggt cct cct ccc agc aat aat gtc ttg ttt aat ggt ttt gcc aaa   768
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255
 
cat ccg acc acg gga gct ggt cag tat gcc acg gtc tct ttg acg aaa   816
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270
 
ggt aag aaa cat cgt ttg cgt ttg att aat acc tct gtt gaa aat cat   864
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285
 
ttt cag ttg tct ttg gtt aat cat tct atg acc att att tct gcc gat   912
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300
 
ttg gtt ccg gtt cag ccg tat aaa gtt gat tct ttg ttg ttg ggc att   960
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320
 
ggt cag cgt tat gat gtc att att gat gct aat cag gcc gtt ggc aat   1008
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335
 
tat tgg ttt aat gtt acc ttt ggt ggt aat gat ttg tgt ggt acg tct   1056
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350
 
gat aat aaa tat cca gcc gcc att ttt cgt tat cag ggt gcg cca aaa   1104
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365
 
gcc tta cct acg aat aag gga gta gca cct ccg gat cat cag tgt ttg   1152
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380
 
gat ttg aat gat ttg aaa cct gtt ttg cag cgt tct ttg aat acc aac   1200
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400
 
tct att gct ctt aat acc ggt aat acc att ccg att acc ttg gat ggt   1248
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415
 
ttt gtt tgg cgt gtt aat ggc acc gcg atc aac att aat tgg aat aaa   1296
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430
 
ccg gtc ctt gaa tat gtt atg acg ggc aat acg aat tat tct cag agt   1344
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445
 
gat aat att gtg cag gtt gaa ggt gtt aat cag tgg aaa tat tgg ttg   1392
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460
 
att gaa aat gat ccg gac ggc gct ttc tct ttg cct cat ccg att cat   1440
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480
 
ttg cat ggt cat gac ttt ttg att ttg ggt cgt tct ccg gat gtt act   1488
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495
 
gcc att tct cag acg cga tat gtt ttt gat ccg gca gtt gat atg gct   1536
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510
 
cgt ttg aat ggt aat aat cct acg cgt cgt gat acc gct atg ttg cca   1584
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525
 
gcc aaa ggt tgg ttg ttg att gcg ttt cgt acc gat aat ccg ggt tct   1632
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540
 
tgg tta atg cat tgt cat att gcg tgg cat gtt tct ggt ggt ttg tct   1680
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560
 
aat cag ttt ttg gaa cgt gcc cag gat ttg cgt aat tct att tct ccg   1728
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575
 
gct gat aaa aag gct ttc aat gat aac tgt gat gct tgg cgt gct tat   1776
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590
 
ttt ccg gat aat gcc ccg ttt cct aaa gat gat tct ggt ttg cgt tct   1824
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605
 
ggg gtt aaa gcc cgc gaa gtt aaa atg aaa tgg                       1857
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615
 

<210> 120
<211> 619
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 120
Met Lys Phe Leu Gly Ile Ala Ala Leu Val Ala Gly Leu Leu Ala Pro
 1               5                  10                  15      
Ser Leu Val Leu Gly Ala Pro Ala Pro Gly Thr Glu Gly Val Asn Leu
            20                  25                  30          
Leu Thr Pro Val Asp Lys Arg Gln Asp Ser Gln Ala Glu Arg Tyr Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Cys Asn Ser Pro Thr Asn Arg Gln Cys Trp
    50                  55                  60                  
Ser Pro Gly Phe Asn Ile Asn Thr Asp Tyr Glu Leu Gly Thr Pro Asn
65                  70                  75                  80  
Thr Gly Lys Thr Arg Arg Tyr Lys Leu Thr Leu Thr Glu Thr Asp Asn
                85                  90                  95      
Trp Leu Gly Pro Asp Gly Val Ile Lys Asp Lys Val Met Met Val Asn
            100                 105                 110         
Asp Asn Ile Ile Gly Pro Thr Ile Gln Ala Asp Trp Gly Asp Tyr Ile
        115                 120                 125             
Glu Ile Thr Val Ile Asn Lys Leu Lys Ser Asn Gly Thr Ser Ile His
    130                 135                 140                 
Trp His Gly Met His Gln Arg Asn Ser Asn Ile Gln Asp Gly Val Asn
145                 150                 155                 160 
Gly Val Thr Glu Cys Pro Ile Pro Pro Arg Gly Gly Ser Lys Val Tyr
                165                 170                 175     
Arg Trp Arg Ala Thr Gln Tyr Gly Thr Ser Trp Tyr His Ser His Phe
            180                 185                 190         
Ser Ala Gln Tyr Gly Asn Gly Ile Val Gly Pro Ile Val Ile Asn Gly
        195                 200                 205             
Pro Ala Ser Ala Asn Tyr Asp Val Asp Leu Gly Pro Phe Pro Leu Thr
    210                 215                 220                 
Asp Tyr Tyr Tyr Asp Thr Ala Asp Arg Leu Val Leu Leu Thr Gln His
225                 230                 235                 240 
Ala Gly Pro Pro Pro Ser Asn Asn Val Leu Phe Asn Gly Phe Ala Lys
                245                 250                 255     
His Pro Thr Thr Gly Ala Gly Gln Tyr Ala Thr Val Ser Leu Thr Lys
            260                 265                 270         
Gly Lys Lys His Arg Leu Arg Leu Ile Asn Thr Ser Val Glu Asn His
        275                 280                 285             
Phe Gln Leu Ser Leu Val Asn His Ser Met Thr Ile Ile Ser Ala Asp
    290                 295                 300                 
Leu Val Pro Val Gln Pro Tyr Lys Val Asp Ser Leu Leu Leu Gly Ile
305                 310                 315                 320 
Gly Gln Arg Tyr Asp Val Ile Ile Asp Ala Asn Gln Ala Val Gly Asn
                325                 330                 335     
Tyr Trp Phe Asn Val Thr Phe Gly Gly Asn Asp Leu Cys Gly Thr Ser
            340                 345                 350         
Asp Asn Lys Tyr Pro Ala Ala Ile Phe Arg Tyr Gln Gly Ala Pro Lys
        355                 360                 365             
Ala Leu Pro Thr Asn Lys Gly Val Ala Pro Pro Asp His Gln Cys Leu
    370                 375                 380                 
Asp Leu Asn Asp Leu Lys Pro Val Leu Gln Arg Ser Leu Asn Thr Asn
385                 390                 395                 400 
Ser Ile Ala Leu Asn Thr Gly Asn Thr Ile Pro Ile Thr Leu Asp Gly
                405                 410                 415     
Phe Val Trp Arg Val Asn Gly Thr Ala Ile Asn Ile Asn Trp Asn Lys
            420                 425                 430         
Pro Val Leu Glu Tyr Val Met Thr Gly Asn Thr Asn Tyr Ser Gln Ser
        435                 440                 445             
Asp Asn Ile Val Gln Val Glu Gly Val Asn Gln Trp Lys Tyr Trp Leu
    450                 455                 460                 
Ile Glu Asn Asp Pro Asp Gly Ala Phe Ser Leu Pro His Pro Ile His
465                 470                 475                 480 
Leu His Gly His Asp Phe Leu Ile Leu Gly Arg Ser Pro Asp Val Thr
                485                 490                 495     
Ala Ile Ser Gln Thr Arg Tyr Val Phe Asp Pro Ala Val Asp Met Ala
            500                 505                 510         
Arg Leu Asn Gly Asn Asn Pro Thr Arg Arg Asp Thr Ala Met Leu Pro
        515                 520                 525             
Ala Lys Gly Trp Leu Leu Ile Ala Phe Arg Thr Asp Asn Pro Gly Ser
    530                 535                 540                 
Trp Leu Met His Cys His Ile Ala Trp His Val Ser Gly Gly Leu Ser
545                 550                 555                 560 
Asn Gln Phe Leu Glu Arg Ala Gln Asp Leu Arg Asn Ser Ile Ser Pro
                565                 570                 575     
Ala Asp Lys Lys Ala Phe Asn Asp Asn Cys Asp Ala Trp Arg Ala Tyr
            580                 585                 590         
Phe Pro Asp Asn Ala Pro Phe Pro Lys Asp Asp Ser Gly Leu Arg Ser
        595                 600                 605             
Gly Val Lys Ala Arg Glu Val Lys Met Lys Trp
    610                 615                 


<210> 121
<211> 1557
<212> DNA
<213> P. cinnabarinus

<220> 
<221> CDS            
<222> (1)...(1557)

<400> 121
atg tcg agg ttc cag tcc ctc ttc ttc ttc gtc ctc gtc tcc ctc acc   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gct gtg gcc aac gca gcc ata ggg cct gtg gcg gac ctg acc ctt acc   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gcc cag gtc agc ccc gat ggc ttc gct cgc gag gcc gtc gtg gtg   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aac ggt atc acc cct gcc cct ctc atc aca ggc aat aag ggc gat cga   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttc cag ctc aat gtc atc gac cag ttg aca aat cat acc atg ttg aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
aca tct agt att cat tgg cac ggc ttc ttc cag caa ggc acg aac tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gcc gat ggt ccc gcg ttc gtg aac cag tgt ccc atc gct tcg ggc cac   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tcg ttc ttg tat gac ttt caa gtt ccc gac caa gca ggg act ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tac cat agc cat ctc tcc acg caa tac tgc gat ggt ttg agg ggg cct   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtc gtc tac gac ccc aac gat cct cac gct agc ctg tat gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aac gac gac act gtc att acg ctg gct gat tgg tat cac gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gcc aag ctc gga cct cgc ttc cca ttt ggc tcc gat tca acc ctt atc   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aat gga ctt ggt cga acc act ggc ata gca ccg tcc gac ttg gca gtt   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
atc aag gtc acg cag ggc aag cgc tac cgc ttc cgc ttg gtg tcg ctt   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgc gat ccg aac cat aca ttc agc att gat aat cac aca atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
ata att gag gcg gac tcg atc aac act caa ccc cta gag gtt gat tca   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
atc cag att ttt gcc gcg cag cgc tac tcc ttc gtg ctg gat gct agc   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccg gtg gat aac tac tgg atc cgc gca aac cct gcc ttc gga aac   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
aca ggt ttt gct ggt gga atc aat tct gcc atc ctg cgt tat gat ggc   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gca ccc gag atc gag cct acg tct gtc cag act act cct acg aag cct   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
ctg aac gag gtc gac ttg cat cct ctc tcg cct atg cct gtg cct ggc   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
agc ccc gag ccc gga ggt gtc gac aag cct ctg aac ttg gtc ttc aac   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttc aac ggc acc aac ttc ttc atc aac gac cac acc ttt gtc ccg ccg   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
tct gtc cca gtc ttg cta caa atc ctc agt ggg gcg cag gcg gct cag   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gac ctg gtc ccg gag ggc agc gtg ttc gtt ctt ccc agc aac tcg tcc   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gag ata tcc ttc cct gcc act gcc aat gcc cct gga ttc ccc cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
ccg ttc cac ttg cac ggt cac gcc ttc gct gtc gtc cgg agc gcc ggg   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
agc agc gtc tac aac tac gac aac ccg atc ttc cgc gac gtc gtc agc   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggc cag ccc ggc gac aac gtc acg att cgc ttc gag acc aat aac   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
cca ggc ccg tgg ttc ctc cac tgc cac att gac ttc cac ctc gac gca   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggc ttt gct gta gtc atg gcc gag gac act ccg gac acc aag gcc gcg   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aac cct gtt cct cag gcg tgg tcg gac ttg tgc ccc atc tat gat gca   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
ctt gac ccc agc gac ctc tga                                       1557
Leu Asp Pro Ser Asp Leu  *
        515
 

<210> 122
<211> 518
<212> PRT
<213> P. cinnabarinus

<400> 122
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 123
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 123
atg tct aga ttt caa tct ttg ttc ttc ttt gta ttg gtt tca ttg act   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gct gtt gct aat gct gct att ggt cca gtt gct gat ttg aca ttg act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gct caa gtt tca cca gat ggt ttt gct aga gaa gct gtt gtt gtt   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aac gga att act cca gct cca ttg att aca ggt aat aaa ggt gat aga   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttt caa tta aat gtc att gat caa ttg act aat cat act atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act tct tct att cat tgg cat ggt ttc ttt caa caa ggt act aat tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gct gac ggt cct gca ttc gtt aat caa tgt cca att gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tca ttt ttg tat gat ttt cag gtt cca gat caa gca ggt act ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cac tct cat ttg tca act caa tat tgt gat ggt ttg aga ggt cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttt gta gtt tat gat cca aat gat cca cat gct tct ttg tat gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat act gta att aca ttg gct gat tgg tat cat gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg ggt cct aga ttt cca ttc ggt tct gat tct aca ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aat ggt ttg ggt aga act act gga att gct cct tct gat ttg gct gta   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
att aaa gta act caa ggt aaa aga tat aga ttt aga tta gta tct ttg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat cca aat cat act ttt tct att gat aat cac act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
att att gaa gca gat tct att aat act caa cca ttg gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
ata caa att ttt gct gct caa aga tat tct ttc gtt ttg gat gct tca   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att aga gct aac cca gca ttt gga aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
aca ggt ttt gca ggt gga att aat tct gct att ttg aga tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct cca gaa att gaa cca act tct gtt caa act act cca act aaa cca   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
tta aat gaa gtt gat tta cat cca tta tca cca atg cct gtt ccc ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
tcc cct gag cct ggt ggt gtt gat aag cca cta aat ttg gtt ttt aat   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttt aat ggt act aat ttc ttt att aat gat cat act ttc gtt cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt ttg ttg caa att ttg tct ggt gca caa gct gct caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gtt cct gaa ggt tct gtt ttt gta ttg cca tct aat tct tct   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt cca gct aca gct aat gct cca ggt ttt cca cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
cca ttt cac tta cat ggt cat gct ttt gct gtt gtt aga tct gct ggt   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gtt tat aat tat gat aat cca att ttt aga gat gtt gtt tca   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt caa ccc gga gat aat gtt act att aga ttt gaa act aat aat   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
cct ggt cca tgg ttt ttg cat tgt cat att gat ttt cat ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttt gct gtt gta atg gct gaa gat act cca gat act aaa gct gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aat cca gtt cct cag gct tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat cca tct gat ttg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 124
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 124
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 125
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 125
tactcaagct t atg tct aga ttt caa tct ttg ttc ttc ttt gta ttg gtt  50
             Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val
              1               5                   10
 
tca ttg act gct gtt gct aat gct gct att ggt cca gtt gct gat ttg   98
Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu
     15                  20                  25
 
aca ttg act aat gct caa gtt tca cca gat ggt ttt gct aga gaa gct   146
Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala
 30                  35                  40                  45
 
gtt gtt gtt aac gga att act cca gct cca ttg att aca ggt aat aaa   194
Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys
                 50                  55                  60
 
ggt gat aga ttt caa tta aat gtc att gat caa ttg act aat cat act   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr
             65                  70                  75
 
atg tta aaa act tct tct att cat tgg cat ggt ttc ttt caa caa ggt   290
Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly
         80                  85                  90
 
act aat tgg gct gac ggt cct gca ttc gtt aat caa tgt cca att gct   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
tct ggt cat tca ttt ttg tat gat ttt cag gtt cca gat caa gca ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
act ttt tgg tat cac tct cat ttg tca act caa tat tgt gat ggt ttg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
aga ggt cca ttt gta gtt tat gat cca aat gat cca cat gct tct ttg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu
            145                 150                 155
 
tat gac att gat aat gat gat act gta att aca ttg gct gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
        160                 165                 170
 
cat gtt gct gct aaa ttg ggt cct aga ttt cca ttc ggt tct gat tct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser
    175                 180                 185
 
aca ttg att aat ggt ttg ggt aga act act gga att gct cct tct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp
190                 195                 200                 205
 
ttg gct gta att aaa gta act caa ggt aaa aga tat aga ttt aga tta   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gta tct ttg tct tgt gat cca aat cat act ttt tct att gat aat cac   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His
            225                 230                 235
 
act atg act att att gaa gca gat tct att aat act caa cca ttg gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtt gat tct ata caa att ttt gct gct caa aga tat tct ttc gtt ttg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gat gct tca caa cca gtt gat aat tat tgg att aga gct aac cca gca   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala
270                 275                 280                 285
 
ttt gga aat aca ggt ttt gca ggt gga att aat tct gct att ttg aga   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tat gat ggt gct cca gaa att gaa cca act tct gtt caa act act cca   962
Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro
            305                 310                 315
 
act aaa cca tta aat gaa gtt gat tta cat cca tta tca cca atg cct   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro
        320                 325                 330
 
gtt ccc ggt tcc cct gag cct ggt ggt gtt gat aag cca cta aat ttg   1058
Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu
    335                 340                 345
 
gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat act ttc   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe
350                 355                 360                 365
 
gtt cca cca tct gtt cca gtt ttg ttg caa att ttg tct ggt gca caa   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct caa gat ttg gtt cct gaa ggt tct gtt ttt gta ttg cca tct   1202
Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser
            385                 390                 395
 
aat tct tct att gaa att tct ttt cca gct aca gct aat gct cca ggt   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
ttt cca cat cca ttt cac tta cat ggt cat gct ttt gct gtt gtt aga   1298
Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg
    415                 420                 425
 
tct gct ggt tct tct gtt tat aat tat gat aat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tca act ggt caa ccc gga gat aat gtt act att aga ttt gaa   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu
                450                 455                 460
 
act aat aat cct ggt cca tgg ttt ttg cat tgt cat att gat ttt cat   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ttg gat gct ggt ttt gct gtt gta atg gct gaa gat act cca gat act   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
aaa gct gct aat cca gtt cct cag gct tgg tct gat ttg tgt cca att   1538
Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tat gat gct tta gat cca tct gat ttg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 126
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 126
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 127
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 127
gaatactcca tatg atg tct aga ttt caa tct ttg ttc ttc ttt gta ttg   50
                Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu
                 1               5                   10
 
gtt tca ttg act gct gtt gct aat gct gct att ggt cca gtt gct gat   98
Val Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp
         15                  20                  25
 
ttg aca ttg act aat gct caa gtt tca cca gat ggt ttt gct aga gaa   146
Leu Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu
     30                  35                  40
 
gct gtt gtt gtt aac gga att act cca gct cca ttg att aca ggt aat   194
Ala Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn
 45                  50                  55                  60
 
aaa ggt gat aga ttt caa tta aat gtc att gat caa ttg act aat cat   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His
                 65                  70                  75
 
act atg tta aaa act tct tct att cat tgg cat ggt ttc ttt caa caa   290
Thr Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln
             80                  85                  90
 
ggt act aat tgg gct gac ggt cct gca ttc gtt aat caa tgt cca att   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile
         95                 100                 105
 
gct tct ggt cat tca ttt ttg tat gat ttt cag gtt cca gat caa gca   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggt act ttt tgg tat cac tct cat ttg tca act caa tat tgt gat ggt   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ttg aga ggt cca ttt gta gtt tat gat cca aat gat cca cat gct tct   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser
                145                 150                 155
 
ttg tat gac att gat aat gat gat act gta att aca ttg gct gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp
            160                 165                 170
 
tat cat gtt gct gct aaa ttg ggt cct aga ttt cca ttc ggt tct gat   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp
        175                 180                 185
 
tct aca ttg att aat ggt ttg ggt aga act act gga att gct cct tct   626
Ser Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser
    190                 195                 200
 
gat ttg gct gta att aaa gta act caa ggt aaa aga tat aga ttt aga   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
tta gta tct ttg tct tgt gat cca aat cat act ttt tct att gat aat   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn
                225                 230                 235
 
cac act atg act att att gaa gca gat tct att aat act caa cca ttg   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtt gat tct ata caa att ttt gct gct caa aga tat tct ttc gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
ttg gat gct tca caa cca gtt gat aat tat tgg att aga gct aac cca   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
gca ttt gga aat aca ggt ttt gca ggt gga att aat tct gct att ttg   914
Ala Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
aga tat gat ggt gct cca gaa att gaa cca act tct gtt caa act act   962
Arg Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr
                305                 310                 315
 
cca act aaa cca tta aat gaa gtt gat tta cat cca tta tca cca atg   1010
Pro Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met
            320                 325                 330
 
cct gtt ccc ggt tcc cct gag cct ggt ggt gtt gat aag cca cta aat   1058
Pro Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn
        335                 340                 345
 
ttg gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat act   1106
Leu Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr
    350                 355                 360
 
ttc gtt cca cca tct gtt cca gtt ttg ttg caa att ttg tct ggt gca   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
caa gct gct caa gat ttg gtt cct gaa ggt tct gtt ttt gta ttg cca   1202
Gln Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro
                385                 390                 395
 
tct aat tct tct att gaa att tct ttt cca gct aca gct aat gct cca   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
ggt ttt cca cat cca ttt cac tta cat ggt cat gct ttt gct gtt gtt   1298
Gly Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val
        415                 420                 425
 
aga tct gct ggt tct tct gtt tat aat tat gat aat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tca act ggt caa ccc gga gat aat gtt act att aga ttt   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
gaa act aat aat cct ggt cca tgg ttt ttg cat tgt cat att gat ttt   1442
Glu Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat ttg gat gct ggt ttt gct gtt gta atg gct gaa gat act cca gat   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
act aaa gct gct aat cca gtt cct cag gct tgg tct gat ttg tgt cca   1538
Thr Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
att tat gat gct tta gat cca tct gat ttg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 128
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 128
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 129
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 129
atg tct cgt ttt cag tct ctg ttc ttc ttc gtt ctg gta tct ctg act   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gcg gtt gcg aat gcg gcg att ggt ccg gtt gct gat ctg act ctg acc   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aac gct cag gtt agc ccg gac ggt ttt gcg cgt gag gcg gtt gtt gtt   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aat ggt atc acc cca gcg cca ctc atc acc ggt aac aaa ggt gac cgt   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttc caa ctg aac gtt att gac cag ctg acc aac cac acc atg ctg aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
acc tct tct atc cat tgg cac ggt ttc ttc caa cag ggt act aat tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gcg gac ggt cca gcg ttc gtt aac cag tgc ccg atc gcg tct ggc cat   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ctg tac gac ttt cag gtt cca gac caa gcg ggt act ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cac tct cac ctg tct acc cag tac tgc gac ggt ctg cgt ggt cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtt tac gac ccg aac gac cca cac gct tct ctg tac gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gac aac gac gac acc gtt atc acc ctc gcg gat tgg tat cac gtt gcg   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gcg aaa ctg ggt cca cgt ttc cca ttc ggt tct gac tct acc ctg atc   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aac ggt ctg ggt cgt acc acc ggt atc gcg cca tct gac ctg gct gtt   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
atc aaa gtt acc cag ggc aag cgt tac cgt ttt cgt ctg gtt agc ctg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgc gac ccg aac cac acc ttc tct atc gat aac cac acc atg acc   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
atc atc gaa gct gat tct atc aac acc cag ccg ctc gaa gtt gac tct   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
atc cag atc ttc gct gct caa cgt tac tct ttc gtt ctg gac gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccg gtt gat aac tat tgg att cgt gcg aac cca gct ttc ggt aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
act ggt ttt gcg ggt ggc atc aac tct gcg att ctg cgt tac gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct ccg gaa atc gaa ccg acc tcc gtt cag acc acc ccg acc aaa ccg   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
ctg aac gaa gtt gac ctg cat cca ctg tct cca atg ccg gtg cca ggc   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
tct cca gaa cca ggc ggc gtg gac aaa cct ctg aac ctc gtt ttc aac   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttc aac ggt act aac ttc ttc atc aac gac cac acc ttt gtt ccg cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
tct gtt ccg gtt ctg ctc caa att ctg tct ggt gcg caa gct gct cag   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gac ctg gtt cca gaa ggt tct gtt ttc gtt ctg ccg tcc aac tct tct   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
atc gaa atc tct ttc cct gcg act gcg aac gct ccg ggt ttc cca cac   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
cca ttc cac ctg cac ggt cac gcg ttt gcg gtt gtt cgt agc gct ggt   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gtt tac aac tac gac aac ccg atc ttt cgt gac gtt gtg tct   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggc caa cca ggt gat aac gtt acc atc cgt ttc gaa act aac aat   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc cac ctg gat gcg   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac acc aaa gct gcg   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aac cca gtt cct cag gct tgg agc gac ctg tgc ccg atc tat gac gct   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
ctg gac cca tct gac ctg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 130
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 130
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 131
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 131
tactcaagct t atg tct cgt ttt cag tct ctg ttc ttc ttc gtt ctg gta  50
             Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val
              1               5                   10
 
tct ctg act gcg gtt gcg aat gcg gcg att ggt ccg gtt gct gat ctg   98
Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu
     15                  20                  25
 
act ctg acc aac gct cag gtt agc ccg gac ggt ttt gcg cgt gag gcg   146
Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala
 30                  35                  40                  45
 
gtt gtt gtt aat ggt atc acc cca gcg cca ctc atc acc ggt aac aaa   194
Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys
                 50                  55                  60
 
ggt gac cgt ttc caa ctg aac gtt att gac cag ctg acc aac cac acc   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr
             65                  70                  75
 
atg ctg aaa acc tct tct atc cat tgg cac ggt ttc ttc caa cag ggt   290
Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly
         80                  85                  90
 
act aat tgg gcg gac ggt cca gcg ttc gtt aac cag tgc ccg atc gcg   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
tct ggc cat tct ttc ctg tac gac ttt cag gtt cca gac caa gcg ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
act ttt tgg tat cac tct cac ctg tct acc cag tac tgc gac ggt ctg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
cgt ggt cca ttc gtt gtt tac gac ccg aac gac cca cac gct tct ctg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu
            145                 150                 155
 
tac gac att gac aac gac gac acc gtt atc acc ctc gcg gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
        160                 165                 170
 
cac gtt gcg gcg aaa ctg ggt cca cgt ttc cca ttc ggt tct gac tct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser
    175                 180                 185
 
acc ctg atc aac ggt ctg ggt cgt acc acc ggt atc gcg cca tct gac   626
Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp
190                 195                 200                 205
 
ctg gct gtt atc aaa gtt acc cag ggc aag cgt tac cgt ttt cgt ctg   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gtt agc ctg tct tgc gac ccg aac cac acc ttc tct atc gat aac cac   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His
            225                 230                 235
 
acc atg acc atc atc gaa gct gat tct atc aac acc cag ccg ctc gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtt gac tct atc cag atc ttc gct gct caa cgt tac tct ttc gtt ctg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gac gct tct cag ccg gtt gat aac tat tgg att cgt gcg aac cca gct   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala
270                 275                 280                 285
 
ttc ggt aat act ggt ttt gcg ggt ggc atc aac tct gcg att ctg cgt   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tac gat ggt gct ccg gaa atc gaa ccg acc tcc gtt cag acc acc ccg   962
Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro
            305                 310                 315
 
acc aaa ccg ctg aac gaa gtt gac ctg cat cca ctg tct cca atg ccg   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro
        320                 325                 330
 
gtg cca ggc tct cca gaa cca ggc ggc gtg gac aaa cct ctg aac ctc   1058
Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu
    335                 340                 345
 
gtt ttc aac ttc aac ggt act aac ttc ttc atc aac gac cac acc ttt   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe
350                 355                 360                 365
 
gtt ccg cca tct gtt ccg gtt ctg ctc caa att ctg tct ggt gcg caa   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct cag gac ctg gtt cca gaa ggt tct gtt ttc gtt ctg ccg tcc   1202
Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser
            385                 390                 395
 
aac tct tct atc gaa atc tct ttc cct gcg act gcg aac gct ccg ggt   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
ttc cca cac cca ttc cac ctg cac ggt cac gcg ttt gcg gtt gtt cgt   1298
Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg
    415                 420                 425
 
agc gct ggt tct tct gtt tac aac tac gac aac ccg atc ttt cgt gac   1346
Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtg tct acc ggc caa cca ggt gat aac gtt acc atc cgt ttc gaa   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu
                450                 455                 460
 
act aac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc cac   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ctg gat gcg ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac acc   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
aaa gct gcg aac cca gtt cct cag gct tgg agc gac ctg tgc ccg atc   1538
Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tat gac gct ctg gac cca tct gac ctg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 132
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 132
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 133
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 133
gaatactcca tatg atg tct cgt ttt cag tct ctg ttc ttc ttc gtt ctg   50
                Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu
                 1               5                   10
 
gta tct ctg act gcg gtt gcg aat gcg gcg att ggt ccg gtt gct gat   98
Val Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp
         15                  20                  25
 
ctg act ctg acc aac gct cag gtt agc ccg gac ggt ttt gcg cgt gag   146
Leu Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu
     30                  35                  40
 
gcg gtt gtt gtt aat ggt atc acc cca gcg cca ctc atc acc ggt aac   194
Ala Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn
 45                  50                  55                  60
 
aaa ggt gac cgt ttc caa ctg aac gtt att gac cag ctg acc aac cac   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His
                 65                  70                  75
 
acc atg ctg aaa acc tct tct atc cat tgg cac ggt ttc ttc caa cag   290
Thr Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln
             80                  85                  90
 
ggt act aat tgg gcg gac ggt cca gcg ttc gtt aac cag tgc ccg atc   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile
         95                 100                 105
 
gcg tct ggc cat tct ttc ctg tac gac ttt cag gtt cca gac caa gcg   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggt act ttt tgg tat cac tct cac ctg tct acc cag tac tgc gac ggt   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ctg cgt ggt cca ttc gtt gtt tac gac ccg aac gac cca cac gct tct   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser
                145                 150                 155
 
ctg tac gac att gac aac gac gac acc gtt atc acc ctc gcg gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp
            160                 165                 170
 
tat cac gtt gcg gcg aaa ctg ggt cca cgt ttc cca ttc ggt tct gac   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp
        175                 180                 185
 
tct acc ctg atc aac ggt ctg ggt cgt acc acc ggt atc gcg cca tct   626
Ser Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser
    190                 195                 200
 
gac ctg gct gtt atc aaa gtt acc cag ggc aag cgt tac cgt ttt cgt   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
ctg gtt agc ctg tct tgc gac ccg aac cac acc ttc tct atc gat aac   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn
                225                 230                 235
 
cac acc atg acc atc atc gaa gct gat tct atc aac acc cag ccg ctc   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtt gac tct atc cag atc ttc gct gct caa cgt tac tct ttc gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
ctg gac gct tct cag ccg gtt gat aac tat tgg att cgt gcg aac cca   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
gct ttc ggt aat act ggt ttt gcg ggt ggc atc aac tct gcg att ctg   914
Ala Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
cgt tac gat ggt gct ccg gaa atc gaa ccg acc tcc gtt cag acc acc   962
Arg Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr
                305                 310                 315
 
ccg acc aaa ccg ctg aac gaa gtt gac ctg cat cca ctg tct cca atg   1010
Pro Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met
            320                 325                 330
 
ccg gtg cca ggc tct cca gaa cca ggc ggc gtg gac aaa cct ctg aac   1058
Pro Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn
        335                 340                 345
 
ctc gtt ttc aac ttc aac ggt act aac ttc ttc atc aac gac cac acc   1106
Leu Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr
    350                 355                 360
 
ttt gtt ccg cca tct gtt ccg gtt ctg ctc caa att ctg tct ggt gcg   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
caa gct gct cag gac ctg gtt cca gaa ggt tct gtt ttc gtt ctg ccg   1202
Gln Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro
                385                 390                 395
 
tcc aac tct tct atc gaa atc tct ttc cct gcg act gcg aac gct ccg   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
ggt ttc cca cac cca ttc cac ctg cac ggt cac gcg ttt gcg gtt gtt   1298
Gly Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val
        415                 420                 425
 
cgt agc gct ggt tct tct gtt tac aac tac gac aac ccg atc ttt cgt   1346
Arg Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gac gtt gtg tct acc ggc caa cca ggt gat aac gtt acc atc cgt ttc   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
gaa act aac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc   1442
Glu Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cac ctg gat gcg ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
acc aaa gct gcg aac cca gtt cct cag gct tgg agc gac ctg tgc ccg   1538
Thr Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
atc tat gac gct ctg gac cca tct gac ctg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 134
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 134
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 135
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 135
atg tct aga ttt caa tca ttg ttc ttc ttt gtt ttg gtt tca ttg act   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gct gtt gct aac gct gct att gga cca gtt gct gat ttg aca ttg act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gca caa gtt tct cca gat gga ttt gca aga gaa gct gtt gtt gtt   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aat gga att act ccc gca cca ttg att aca gga aat aaa ggc gat aga   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttt caa tta aat gtt att gat caa ttg act aac cat act atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act tct tct att cat tgg cat gga ttc ttt caa caa gga aca aat tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gca gat gga cca gct ttt gtt aat caa tgt cca att gct agt ggt cat   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tca ttt ttg tat gat ttt caa gtt cca gat caa gca ggt act ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cac tct cat ttg tct act caa tat tgt gat gga ttg agg ggt cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttt gtt gtt tat gat cca aat gat cca cat gct tca ttg tat gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gac act gtt att act tta gct gat tgg tat cat gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg gga cct aga ttt cca ttt ggt tct gat tct act tta att   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aat gga ttg ggt aga act act gga att gct cct tct gat ttg gct gtt   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
att aaa gtt act caa gga aaa aga tat aga ttt aga ttg gtt tct tta   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat cca aat cat act ttt tct att gat aat cat act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
att att gaa gct gat tct att aat act caa cct tta gaa gtc gat tct   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
att caa att ttt gca gct caa aga tat tct ttt gtt tta gat gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att cgt gct aat ccc gct ttt ggt aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
act gga ttc gct gga gga att aat tct gct att ttg aga tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct cca gaa att gaa cca act tct gtt caa act act cca act aaa cct   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
tta aat gaa gtt gat ttg cat cct ttg tct cca atg cca gtt cca gga   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
tct cca gaa cca gga ggt gtt gat aag cca tta aat ttg gtt ttt aat   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttt aac gga aca aat ttc ttc att aat gat cat act ttt gtt cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt ttg ttg caa att ttg tct ggt gct cag gct gct caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gtt cca gaa gga tct gtt ttt gtt ttg cca tct aat tct tct   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt ccc gct act gct aat gca cca gga ttt cca cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
cca ttt cac ttg cat gga cac gct ttc gct gtt gtt agg tct gct gga   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gtt tat aat tat gat aat cca att ttt aga gat gtt gtt tca   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
aca gga caa cca gga gat aat gtt act att aga ttt gag act aat aat   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttt gca gtt gtt atg gct gaa gat act cca gat act aaa gca gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aat cca gtt cct caa gca tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat cca tct gat ttg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 136
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 136
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 137
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 137
tactcaagct t atg tct aga ttt caa tca ttg ttc ttc ttt gtt ttg gtt  50
             Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val
              1               5                   10
 
tca ttg act gct gtt gct aac gct gct att gga cca gtt gct gat ttg   98
Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu
     15                  20                  25
 
aca ttg act aat gca caa gtt tct cca gat gga ttt gca aga gaa gct   146
Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala
 30                  35                  40                  45
 
gtt gtt gtt aat gga att act ccc gca cca ttg att aca gga aat aaa   194
Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys
                 50                  55                  60
 
ggc gat aga ttt caa tta aat gtt att gat caa ttg act aac cat act   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr
             65                  70                  75
 
atg tta aaa act tct tct att cat tgg cat gga ttc ttt caa caa gga   290
Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly
         80                  85                  90
 
aca aat tgg gca gat gga cca gct ttt gtt aat caa tgt cca att gct   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
agt ggt cat tca ttt ttg tat gat ttt caa gtt cca gat caa gca ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
act ttt tgg tat cac tct cat ttg tct act caa tat tgt gat gga ttg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
agg ggt cca ttt gtt gtt tat gat cca aat gat cca cat gct tca ttg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu
            145                 150                 155
 
tat gac att gat aat gat gac act gtt att act tta gct gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr
        160                 165                 170
 
cat gtt gct gct aaa ttg gga cct aga ttt cca ttt ggt tct gat tct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser
    175                 180                 185
 
act tta att aat gga ttg ggt aga act act gga att gct cct tct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp
190                 195                 200                 205
 
ttg gct gtt att aaa gtt act caa gga aaa aga tat aga ttt aga ttg   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gtt tct tta tct tgt gat cca aat cat act ttt tct att gat aat cat   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His
            225                 230                 235
 
act atg act att att gaa gct gat tct att aat act caa cct tta gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtc gat tct att caa att ttt gca gct caa aga tat tct ttt gtt tta   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gat gct tct caa cca gtt gat aat tat tgg att cgt gct aat ccc gct   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala
270                 275                 280                 285
 
ttt ggt aat act gga ttc gct gga gga att aat tct gct att ttg aga   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tat gat ggt gct cca gaa att gaa cca act tct gtt caa act act cca   962
Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro
            305                 310                 315
 
act aaa cct tta aat gaa gtt gat ttg cat cct ttg tct cca atg cca   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro
        320                 325                 330
 
gtt cca gga tct cca gaa cca gga ggt gtt gat aag cca tta aat ttg   1058
Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu
    335                 340                 345
 
gtt ttt aat ttt aac gga aca aat ttc ttc att aat gat cat act ttt   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe
350                 355                 360                 365
 
gtt cca cca tct gtt cca gtt ttg ttg caa att ttg tct ggt gct cag   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct caa gat ttg gtt cca gaa gga tct gtt ttt gtt ttg cca tct   1202
Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser
            385                 390                 395
 
aat tct tct att gaa att tct ttt ccc gct act gct aat gca cca gga   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
ttt cca cat cca ttt cac ttg cat gga cac gct ttc gct gtt gtt agg   1298
Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg
    415                 420                 425
 
tct gct gga tct tct gtt tat aat tat gat aat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tca aca gga caa cca gga gat aat gtt act att aga ttt gag   1394
Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu
                450                 455                 460
 
act aat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ttg gat gct ggt ttt gca gtt gtt atg gct gaa gat act cca gat act   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
aaa gca gct aat cca gtt cct caa gca tgg tct gat ttg tgt cca att   1538
Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tat gat gct tta gat cca tct gat ttg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 138
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 138
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 139
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 139
gaatactcca tatg atg tct aga ttt caa tca ttg ttc ttc ttt gtt ttg   50
                Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu
                 1               5                   10
 
gtt tca ttg act gct gtt gct aac gct gct att gga cca gtt gct gat   98
Val Ser Leu Thr Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp
         15                  20                  25
 
ttg aca ttg act aat gca caa gtt tct cca gat gga ttt gca aga gaa   146
Leu Thr Leu Thr Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu
     30                  35                  40
 
gct gtt gtt gtt aat gga att act ccc gca cca ttg att aca gga aat   194
Ala Val Val Val Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn
 45                  50                  55                  60
 
aaa ggc gat aga ttt caa tta aat gtt att gat caa ttg act aac cat   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His
                 65                  70                  75
 
act atg tta aaa act tct tct att cat tgg cat gga ttc ttt caa caa   290
Thr Met Leu Lys Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln
             80                  85                  90
 
gga aca aat tgg gca gat gga cca gct ttt gtt aat caa tgt cca att   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile
         95                 100                 105
 
gct agt ggt cat tca ttt ttg tat gat ttt caa gtt cca gat caa gca   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggt act ttt tgg tat cac tct cat ttg tct act caa tat tgt gat gga   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ttg agg ggt cca ttt gtt gtt tat gat cca aat gat cca cat gct tca   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser
                145                 150                 155
 
ttg tat gac att gat aat gat gac act gtt att act tta gct gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp
            160                 165                 170
 
tat cat gtt gct gct aaa ttg gga cct aga ttt cca ttt ggt tct gat   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp
        175                 180                 185
 
tct act tta att aat gga ttg ggt aga act act gga att gct cct tct   626
Ser Thr Leu Ile Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser
    190                 195                 200
 
gat ttg gct gtt att aaa gtt act caa gga aaa aga tat aga ttt aga   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
ttg gtt tct tta tct tgt gat cca aat cat act ttt tct att gat aat   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn
                225                 230                 235
 
cat act atg act att att gaa gct gat tct att aat act caa cct tta   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtc gat tct att caa att ttt gca gct caa aga tat tct ttt gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
tta gat gct tct caa cca gtt gat aat tat tgg att cgt gct aat ccc   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
gct ttt ggt aat act gga ttc gct gga gga att aat tct gct att ttg   914
Ala Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
aga tat gat ggt gct cca gaa att gaa cca act tct gtt caa act act   962
Arg Tyr Asp Gly Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr
                305                 310                 315
 
cca act aaa cct tta aat gaa gtt gat ttg cat cct ttg tct cca atg   1010
Pro Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met
            320                 325                 330
 
cca gtt cca gga tct cca gaa cca gga ggt gtt gat aag cca tta aat   1058
Pro Val Pro Gly Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn
        335                 340                 345
 
ttg gtt ttt aat ttt aac gga aca aat ttc ttc att aat gat cat act   1106
Leu Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr
    350                 355                 360
 
ttt gtt cca cca tct gtt cca gtt ttg ttg caa att ttg tct ggt gct   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cag gct gct caa gat ttg gtt cca gaa gga tct gtt ttt gtt ttg cca   1202
Gln Ala Ala Gln Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro
                385                 390                 395
 
tct aat tct tct att gaa att tct ttt ccc gct act gct aat gca cca   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
gga ttt cca cat cca ttt cac ttg cat gga cac gct ttc gct gtt gtt   1298
Gly Phe Pro His Pro Phe His Leu His Gly His Ala Phe Ala Val Val
        415                 420                 425
 
agg tct gct gga tct tct gtt tat aat tat gat aat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tca aca gga caa cca gga gat aat gtt act att aga ttt   1394
Asp Val Val Ser Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
gag act aat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt   1442
Glu Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat ttg gat gct ggt ttt gca gtt gtt atg gct gaa gat act cca gat   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
act aaa gca gct aat cca gtt cct caa gca tgg tct gat ttg tgt cca   1538
Thr Lys Ala Ala Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
att tat gat gct tta gat cca tct gat ttg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 140
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 140
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 141
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 141
atg tct aga ttc cag tca ttg ttc ttc ttc gtt ttg gtt tct tta act   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gct gtt gct aat gct gct att ggt cca gtt gct gat ttg act tta act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gct caa gtt tca cca gat ggt ttc gct aga gaa gct gtt gtt gtt   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aat gga att act cca gct cca ttg att act ggt aat aaa ggt gat aga   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttt caa tta aat gtt att gat caa ttg act aac cat acc atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act tct tct att cat tgg cat ggt ttc ttc cag caa ggt aca aat tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gct gat ggt cct gct ttc gtt aat caa tgt cca att gca tct ggt cat   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ttg tat gat ttc cag gtt cca gat caa gct ggt aca ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tct act caa tat tgt gat ggt ttg aga ggt cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtt tat gat cca aat gat cca cat gct tca ttg tat gat ata   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat act gtt att aca ttg gct gat tgg tat cat gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg ggt cca agg ttc ccg ttc ggt tct gat tct aca ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aat ggc ttg ggt aga act act gga att gct ccg tca gat ttg gct gtt   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
att aaa gtt act caa ggt aag aga tat aga ttc aga ttg gtt tct ctt   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
agt tgt gat cca aat cat acc ttc tct att gat aat cat act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
att att gaa gct gat tct att aat act caa cca ttg gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
atc caa att ttc gct gct caa aga tat tct ttc gtt ctg gat gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att aga gct aat cca gcc ttt ggt aac   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
act ggc ttc gct ggt gga att aat tct gct att ttg aga tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct cca gaa att gaa cca act tct gtt caa act act cca act aaa cct   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
tta aac gaa gtt gat ttg cat cca ttg tca cca atg cca gtt cca ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
agc cct gaa cca ggt ggt gtt gac aaa cca tta aac ttg gtt ttc aat   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttc aat gga act aat ttc ttc att aat gat cat act ttc gtt cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt ttg ttg caa att ttg tct ggt gcg caa gct gcc cag   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gtt cct gaa ggt tct gtt ttt gtg ttg cca tct aat tct tct   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt cca gct act gct aac gct ccg gga ttt cca cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
cca ttt cat ttg cac ggt cac gct ttt gcg gta gtg aga tct gct ggt   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gtt tat aat tat gat aat cca att ttc aga gat gtt gtt tct   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt caa cca ggg gat aac gtg act att aga ttc gaa act aat aat   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
cct ggt ccg tgg ttt tta cat tgt cat att gat ttt cat ttg gat gca   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
gga ttc gca gtc gtt atg gct gaa gat act cca gat act aaa gct gca   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aat ccg gtt cct cag gcg tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat cca tct gat tta                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 142
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 142
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 143
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 143
atg tct cgt ttt cag tct ttg ttt ttc ttc gtt ttg gtt tct ttg acc   48
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                   10                  15
 
gcc gtt gct aat gcc gcc ata ggt ccg gtt gcc gat ttg acc ttg acg   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gcc cag gtt tct ccg gat ggt ttt gct cgt gaa gct gtt gtt gtt   144
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
         35                  40                  45
 
aat ggc att acc ccg gcc cct tta att acg gga aac aaa ggt gat cgt   192
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
     50                  55                  60
 
ttt caa ctt aat gtc att gat cag ttg acc aac cat acc atg ttg aaa   240
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
acc tct tct att cat tgg cat ggt ttc ttt cag cag ggt acg aat tgg   288
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                 85                  90                  95
 
gct gac ggt ccc gct ttc gtt aat cag tgt ccg ata gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
agc ttt ttg tat gat ttt cag gtt cct gat caa gct gga acg ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tct acc cag tat tgt gat ggt ttg cgt ggt ccg   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtt tat gat ccg aat gat cct cat gcc tct ttg tat gat atc   480
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat acc gtc att acc ctt gca gat tgg tat cat gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg ggt cca cgt ttt ccg ttt ggt tct gat tct acc ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190
 
aat ggt ttg ggt cgt acc acc ggt ata gcc cca agt gat ttg gct gtt   624
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205
 
atc aaa gtt acc cag ggc aaa cgt tat cgc ttc cgc tta gtg tct ctt   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat ccg aac cat aca ttt tct att gat aat cat acg atg acc   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240
 
att att gag gcc gac tcg att aat acc cag ccg ctt gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
att cag att ttt gct gca cag cgt tat tct ttt gtt ttg gat gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccg gta gat aat tat tgg att cgt gct aat cca gca ttt ggt aac   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285
 
aca ggt ttc gca gga ggt ata aat tct gcc att ttg cgt tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct ccg gaa att gaa ccg acc tct gtt cag acc acc ccg aca aaa ccg   960
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320
 
ctt aat gag gtt gac tta cat ccg ttg tct cct atg cca gta cca ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335
 
tct cct gag cca ggt ggt gtt gat aaa cct ctt aac ttg gtt ttt aat   1056
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350
 
ttt aat ggc acg aac ttc ttc att aat gat cat acc ttt gtt cca cct   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365
 
agt gtt cct gtc ttg ttg cag att ttg tct ggt gcg caa gct gcc caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gtt ccg gaa ggt agc gtt ttc gtt ttg ccg tct aat tct tct   1200
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt cct gct acg gcc aac gcc cca gga ttt ccc cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415
 
cct ttt cat tta cat gga cat gcc ttc gca gtc gtt cgt agt gct ggt   1296
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gtt tat aat tat gat aat ccg att ttt cgt gat gtt gtt tct   1344
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
aca ggt cag cct ggt gac aat gtt acc ata cgt ttt gaa act aac aat   1392
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460
 
cct gga cct tgg ttc ctt cat tgt cat att gat ttt cat ttg gac gca   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggc ttt gct gta gtc atg gct gaa gat acc cct gat acc aaa gca gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495
 
aat cct gtc cct cag gct tgg tct gat ttg tgt cct atc tat gat gct   1536
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat ccg tct gat ctt                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 144
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 144
Met Ser Arg Phe Gln Ser Leu Phe Phe Phe Val Leu Val Ser Leu Thr
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Val Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Gln Val Ser Pro Asp Gly Phe Ala Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Ile Thr Pro Ala Pro Leu Ile Thr Gly Asn Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Gln Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Ser Ser Ile His Trp His Gly Phe Phe Gln Gln Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Val Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro His Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Ala Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Phe Gly Ser Asp Ser Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Thr Thr Gly Ile Ala Pro Ser Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Asn His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Ile Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ala Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Ile Glu Pro Thr Ser Val Gln Thr Thr Pro Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Ser Pro Met Pro Val Pro Gly
                325                 330                 335     
Ser Pro Glu Pro Gly Gly Val Asp Lys Pro Leu Asn Leu Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Thr Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Val Pro Glu Gly Ser Val Phe Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Phe Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Ala Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Val Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Gln Pro Gly Asp Asn Val Thr Ile Arg Phe Glu Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Lys Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ala Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 145
<211> 1557
<212> DNA
<213> P. coccineus

<220> 
<221> CDS            
<222> (1)...(1557)

<400> 145
atg tcg agg ttc cag tct ctt ctc tcc ttc gtc ctc gtc tcc ctt gcc   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gcc gtg gcg aac gct gcc atc ggc cct atg gca gac ttg acc ctc acc   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gcc gcg gtc agc cct gat ggc ttc agc cgt gag gct gtc gtg gtc   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aac ggc caa acc cct ggg cct ctc att gcc ggt cag aaa ggc gac cgt   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttc cag ctg aat gtc att gac aat ttg acg aac cac acc atg ttg aag   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
acc acc agt atc cac tgg cat ggc ttc ttc cag cat ggc aca aac tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gcc gac ggc ccc gcg ttc atc aac cag tgt ccc att gca tcc ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tcc ttc tta tac gac ttt cag gtc cct gac caa gca ggg acc ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tac cac agc cat ctt tcc acg cag tac tgc gat ggt ttg agg ggg ccg   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtc tat gat ccc aac gat ccc cag gct agc ctc tat gac ata   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gac acg gtc att act ttg gtt gat tgg tac cac gtc gcc   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ctg ggg cca cgc ttc ccg ctt ggg gcg gac gcg acc ctc atc   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aat gga ctc ggt cgt agc ccc ggt acg act gcg gct gac ttg gct gtg   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
atc aaa gtc aca cag ggc aag cgg tac cgt ttc cgc ttg gtg tct ctc   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgc gac ccg aat cat acc ttc agc att gat ggc cac acc atg acc   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
atc atc gag gca gac tca gtg aac aca caa cct ctt gag gtt gac tcg   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
atc cag atc ttc gcc gcg cag cgg tac tcc ttc gtg ctg gat gcc agc   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccc gtg gac aac tac tgg atc cgc gcc aat cct tcc ttc gga aac   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
acc ggg ttc gcc ggt ggg att aac tcc gcc atc ctc cgg tat gac ggc   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gcg ccc gag gtc gag cct acc acg acc cag acc act tcc acg aag cct   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
ctg aac gag gtt gac ttg cac ccg ctc acc cct atg gct gtg cct ggc   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
cgt ccc gag ccc gga ggt gtt gac aca ccg ctg aac atg gtc ttc aac   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttt aac ggc acg aat ttc ttc atc aac gac cac tcc ttc gtc cca cct   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
tct gtt ccg gtc ttg ctc cag att ctg agc ggt gcc cag gca gca caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ctg gcc ccg tca ggt agc gtc tat gtg ctt ccc agc aac tcg tcc   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
atc gaa atc tcc ttc cct gcg act gcc aat gct cct ggc gcg ccg cac   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
ccg ttc cac ctg cac ggt cat acc ttc gct gtc gtc cga agc gca gga   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
agc agc gag tac aac tac gat aac ccg atc ttc cgc gac gtt gtc agc   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggt acg ccc ggc gat aat gtc acc atc cgc ttc cag acc aac aac   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
cct ggc ccg tgg ttc ctc cat tgc cac att gac ttc cac ttg gat gcc   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggc ttt gct gtc gtc atg gcc gag gac act ccg gac acg gca gcg gcc   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aac cct gtc ccc cag tcg tgg tcg gat ttg tgc ccg atc tac gac gcg   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
ctt gac cct agc gat ctc tga                                       1557
Leu Asp Pro Ser Asp Leu  *
        515
 

<210> 146
<211> 518
<212> PRT
<213> P. coccineus

<400> 146
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 147
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 147
atg tct aga ttt caa tct ttg ttg tct ttt gta ttg gta tct ttg gct   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gct gtt gct aac gct gct ata ggt cca atg gcc gac ttg aca tta act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gca gca gta tca cca gat ggt ttt tct aga gaa gct gtt gta gtt   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aat ggt caa act cca ggt cct ttg att gca ggt caa aaa ggt gat aga   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttt cag tta aat gta att gat aat ttg act aat cat act atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act act tct att cat tgg cat ggt ttc ttt caa cat ggt act aat tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gct gat ggt ccc gct ttt att aat caa tgt cca att gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ttg tat gat ttt caa gtt cct gat caa gct ggt aca ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tca act caa tat tgt gat ggt ttg aga ggt cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttt gta gtt tat gat cct aat gac cca caa gca tct ttg tat gat ata   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat act gta att aca ttg gtt gat tgg tat cat gtt gca   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg ggt ccc aga ttt cca tta ggt gct gat gct aca ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aat ggt ttg ggt aga tct cct ggt aca act gct gct gat ttg gct gta   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
att aaa gta act caa ggt aaa aga tat aga ttt aga ttg gtt tca ttg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat cca aat cat act ttt tct att gat gga cat act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
att att gaa gct gat tct gtt aat act caa cca ttg gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
ata caa ata ttt gct gct caa aga tat tct ttc gtt ttg gat gct tca   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att aga gct aac cca tct ttc ggt aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
aca ggt ttt gct ggt gga att aat tct gct att ttg aga tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct cca gaa gtt gaa cct act act act caa act act tca act aaa cca   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
tta aat gaa gtt gat ttg cat cca ttg aca cct atg gca gtt ccc ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
aga cca gag cct gga gga gtt gat aca cct tta aat atg gtt ttt aat   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttt aat ggt act aat ttc ttt att aat gat cat tct ttt gta cca cct   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
tct gta ccc gtt ttg ttg caa att ttg tct ggt gca caa gct gct caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gct cca tct ggt tct gtt tat gtt ttg cca tct aat tct tct   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt cca gct aca gct aat gct cca ggc gca cca cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
cca ttt cat ttg cac ggt cat act ttt gct gtt gtt aga tct gct ggt   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tca tct gaa tat aat tat gat aat cca att ttt aga gat gtt gtt tca   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
aca ggt aca cca gga gat aat gtt act att aga ttt caa act aat aat   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
cct ggt cca tgg ttt ttg cat tgt cat att gat ttt cat ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttc gct gtt gtt atg gct gaa gat act cca gat act gct gcc gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aat cca gtt cct cag tct tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat cca tct gat ttg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 148
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 148
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 149
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 149
tactcaagct t atg tct aga ttt caa tct ttg ttg tct ttt gta ttg gta  50
             Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val
              1               5                   10
 
tct ttg gct gct gtt gct aac gct gct ata ggt cca atg gcc gac ttg   98
Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu
     15                  20                  25
 
aca tta act aat gca gca gta tca cca gat ggt ttt tct aga gaa gct   146
Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala
 30                  35                  40                  45
 
gtt gta gtt aat ggt caa act cca ggt cct ttg att gca ggt caa aaa   194
Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys
                 50                  55                  60
 
ggt gat aga ttt cag tta aat gta att gat aat ttg act aat cat act   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr
             65                  70                  75
 
atg tta aaa act act tct att cat tgg cat ggt ttc ttt caa cat ggt   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly
         80                  85                  90
 
act aat tgg gct gat ggt ccc gct ttt att aat caa tgt cca att gct   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
tct ggt cat tct ttc ttg tat gat ttt caa gtt cct gat caa gct ggt   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
aca ttc tgg tat cat tct cat ttg tca act caa tat tgt gat ggt ttg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
aga ggt cca ttt gta gtt tat gat cct aat gac cca caa gca tct ttg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu
            145                 150                 155
 
tat gat ata gat aat gat gat act gta att aca ttg gtt gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr
        160                 165                 170
 
cat gtt gca gct aaa ttg ggt ccc aga ttt cca tta ggt gct gat gct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala
    175                 180                 185
 
aca ttg att aat ggt ttg ggt aga tct cct ggt aca act gct gct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp
190                 195                 200                 205
 
ttg gct gta att aaa gta act caa ggt aaa aga tat aga ttt aga ttg   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gtt tca ttg tct tgt gat cca aat cat act ttt tct att gat gga cat   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
            225                 230                 235
 
act atg act att att gaa gct gat tct gtt aat act caa cca ttg gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtt gat tct ata caa ata ttt gct gct caa aga tat tct ttc gtt ttg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gat gct tca caa cca gtt gat aat tat tgg att aga gct aac cca tct   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
270                 275                 280                 285
 
ttc ggt aat aca ggt ttt gct ggt gga att aat tct gct att ttg aga   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tat gat ggt gct cca gaa gtt gaa cct act act act caa act act tca   962
Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser
            305                 310                 315
 
act aaa cca tta aat gaa gtt gat ttg cat cca ttg aca cct atg gca   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala
        320                 325                 330
 
gtt ccc ggt aga cca gag cct gga gga gtt gat aca cct tta aat atg   1058
Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met
    335                 340                 345
 
gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat tct ttt   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe
350                 355                 360                 365
 
gta cca cct tct gta ccc gtt ttg ttg caa att ttg tct ggt gca caa   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct caa gat ttg gct cca tct ggt tct gtt tat gtt ttg cca tct   1202
Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser
            385                 390                 395
 
aat tct tct att gaa att tct ttt cca gct aca gct aat gct cca ggc   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
gca cca cat cca ttt cat ttg cac ggt cat act ttt gct gtt gtt aga   1298
Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg
    415                 420                 425
 
tct gct ggt tca tct gaa tat aat tat gat aat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tca aca ggt aca cca gga gat aat gtt act att aga ttt caa   1394
Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln
                450                 455                 460
 
act aat aat cct ggt cca tgg ttt ttg cat tgt cat att gat ttt cat   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ttg gat gct ggt ttc gct gtt gtt atg gct gaa gat act cca gat act   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
gct gcc gct aat cca gtt cct cag tct tgg tct gat ttg tgt cca att   1538
Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tat gat gct tta gat cca tct gat ttg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 150
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 150
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 151
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 151
gaatactcca tatg atg tct aga ttt caa tct ttg ttg tct ttt gta ttg   50
                Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu
                 1               5                   10
 
gta tct ttg gct gct gtt gct aac gct gct ata ggt cca atg gcc gac   98
Val Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp
         15                  20                  25
 
ttg aca tta act aat gca gca gta tca cca gat ggt ttt tct aga gaa   146
Leu Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu
     30                  35                  40
 
gct gtt gta gtt aat ggt caa act cca ggt cct ttg att gca ggt caa   194
Ala Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln
 45                  50                  55                  60
 
aaa ggt gat aga ttt cag tta aat gta att gat aat ttg act aat cat   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His
                 65                  70                  75
 
act atg tta aaa act act tct att cat tgg cat ggt ttc ttt caa cat   290
Thr Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His
             80                  85                  90
 
ggt act aat tgg gct gat ggt ccc gct ttt att aat caa tgt cca att   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile
         95                 100                 105
 
gct tct ggt cat tct ttc ttg tat gat ttt caa gtt cct gat caa gct   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggt aca ttc tgg tat cat tct cat ttg tca act caa tat tgt gat ggt   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ttg aga ggt cca ttt gta gtt tat gat cct aat gac cca caa gca tct   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser
                145                 150                 155
 
ttg tat gat ata gat aat gat gat act gta att aca ttg gtt gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp
            160                 165                 170
 
tat cat gtt gca gct aaa ttg ggt ccc aga ttt cca tta ggt gct gat   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp
        175                 180                 185
 
gct aca ttg att aat ggt ttg ggt aga tct cct ggt aca act gct gct   626
Ala Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala
    190                 195                 200
 
gat ttg gct gta att aaa gta act caa ggt aaa aga tat aga ttt aga   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
ttg gtt tca ttg tct tgt gat cca aat cat act ttt tct att gat gga   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly
                225                 230                 235
 
cat act atg act att att gaa gct gat tct gtt aat act caa cca ttg   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtt gat tct ata caa ata ttt gct gct caa aga tat tct ttc gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
ttg gat gct tca caa cca gtt gat aat tat tgg att aga gct aac cca   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
tct ttc ggt aat aca ggt ttt gct ggt gga att aat tct gct att ttg   914
Ser Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
aga tat gat ggt gct cca gaa gtt gaa cct act act act caa act act   962
Arg Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr
                305                 310                 315
 
tca act aaa cca tta aat gaa gtt gat ttg cat cca ttg aca cct atg   1010
Ser Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met
            320                 325                 330
 
gca gtt ccc ggt aga cca gag cct gga gga gtt gat aca cct tta aat   1058
Ala Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn
        335                 340                 345
 
atg gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat tct   1106
Met Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser
    350                 355                 360
 
ttt gta cca cct tct gta ccc gtt ttg ttg caa att ttg tct ggt gca   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
caa gct gct caa gat ttg gct cca tct ggt tct gtt tat gtt ttg cca   1202
Gln Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro
                385                 390                 395
 
tct aat tct tct att gaa att tct ttt cca gct aca gct aat gct cca   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
ggc gca cca cat cca ttt cat ttg cac ggt cat act ttt gct gtt gtt   1298
Gly Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val
        415                 420                 425
 
aga tct gct ggt tca tct gaa tat aat tat gat aat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tca aca ggt aca cca gga gat aat gtt act att aga ttt   1394
Asp Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
caa act aat aat cct ggt cca tgg ttt ttg cat tgt cat att gat ttt   1442
Gln Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat ttg gat gct ggt ttc gct gtt gtt atg gct gaa gat act cca gat   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
act gct gcc gct aat cca gtt cct cag tct tgg tct gat ttg tgt cca   1538
Thr Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
att tat gat gct tta gat cca tct gat ttg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 152
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 152
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 153
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 153
atg tct cgt ttc caa tct ctg ctg tct ttc gtt ctc gtg tct ctg gct   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gct gtt gct aat gcg gcg atc ggt cca atg gca gac ctg acc ctg acc   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aac gcg gct gtt agc ccg gac ggt ttc tct cgt gag gcg gtt gtt gtt   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aac ggt caa act ccg ggt cca ctg atc gcg ggt cag aaa ggt gac cgt   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttt cag ctg aac gtt att gac aac ctg acc aac cac acc atg ctg aaa   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
acc acc tct atc cat tgg cac ggt ttc ttt cag cac ggt act aat tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gcg gac ggt cca gcg ttc atc aac cag tgc ccg att gcg tct ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ctg tac gac ttt cag gtt ccg gac caa gct ggc acc ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cac tct cac ctg tct acc cag tac tgc gat ggt ctg cgt ggt ccg   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtt tac gac cca aac gac ccg cag gct tct ctg tac gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gac aac gac gac acc gtt atc acc ctg gtt gat tgg tat cac gtt gcg   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gcg aaa ctg ggt cca cgt ttt ccg ctg ggc gct gat gct acc ctg atc   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aac ggc ctg ggt cgt tct ccg ggt act acc gct gcc gac ctc gct gtt   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
atc aaa gtt acc cag ggt aag cgt tac cgt ttt cgt ctg gtt agc ctg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgc gac ccg aac cac acc ttc tct att gac ggt cac acc atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
atc atc gaa gct gat tct gtt aac acc cag ccg ctc gaa gtt gac tct   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
atc cag atc ttc gcg gct caa cgt tac tct ttc gtt ctg gac gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccg gtt gac aac tat tgg att cgt gct aat ccg tct ttt ggc aac   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
act ggt ttc gct ggt ggt atc aac tct gcg att ctg cgt tac gac ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct ccg gaa gtt gaa ccg acc acc act cag acc acc tct acc aaa ccg   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
ctg aac gaa gtt gac ctg cac cca ctg act ccg atg gca gtt cca ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
cgc cca gaa ccg ggt ggt gtt gac act ccg ctg aac atg gtt ttc aac   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttc aac ggt act aac ttc ttc atc aac gac cac tct ttc gtt cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt ctg ttg caa atc ctg tct ggt gcg cag gct gct cag   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gac ctt gcg ccg tct ggc tct gtt tac gtt ctg ccg tcc aac tcc tct   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
atc gaa atc tct ttc cca gct acc gct aat gct cca ggc gct ccg cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
cca ttc cac ctg cac ggt cac acc ttc gcg gtt gtt cgc tct gct ggt   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gaa tac aac tac gac aac ccg atc ttt cgt gat gtt gtt tcg   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggt act cca ggt gac aac gtt acc atc cgt ttc caa act aac aat   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc cac ctg gat gcg   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac act gct gct gcg   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aac cca gta ccg caa tct tgg tct gac ctg tgc ccg atc tac gac gct   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
ctg gac cca tct gac ctg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 154
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 154
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 155
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 155
tactcaagct t atg tct cgt ttc caa tct ctg ctg tct ttc gtt ctc gtg  50
             Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val
              1               5                   10
 
tct ctg gct gct gtt gct aat gcg gcg atc ggt cca atg gca gac ctg   98
Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu
     15                  20                  25
 
acc ctg acc aac gcg gct gtt agc ccg gac ggt ttc tct cgt gag gcg   146
Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala
 30                  35                  40                  45
 
gtt gtt gtt aac ggt caa act ccg ggt cca ctg atc gcg ggt cag aaa   194
Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys
                 50                  55                  60
 
ggt gac cgt ttt cag ctg aac gtt att gac aac ctg acc aac cac acc   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr
             65                  70                  75
 
atg ctg aaa acc acc tct atc cat tgg cac ggt ttc ttt cag cac ggt   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly
         80                  85                  90
 
act aat tgg gcg gac ggt cca gcg ttc atc aac cag tgc ccg att gcg   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
tct ggt cat tct ttc ctg tac gac ttt cag gtt ccg gac caa gct ggc   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
acc ttt tgg tat cac tct cac ctg tct acc cag tac tgc gat ggt ctg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
cgt ggt ccg ttc gtt gtt tac gac cca aac gac ccg cag gct tct ctg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu
            145                 150                 155
 
tac gac att gac aac gac gac acc gtt atc acc ctg gtt gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr
        160                 165                 170
 
cac gtt gcg gcg aaa ctg ggt cca cgt ttt ccg ctg ggc gct gat gct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala
    175                 180                 185
 
acc ctg atc aac ggc ctg ggt cgt tct ccg ggt act acc gct gcc gac   626
Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp
190                 195                 200                 205
 
ctc gct gtt atc aaa gtt acc cag ggt aag cgt tac cgt ttt cgt ctg   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gtt agc ctg tct tgc gac ccg aac cac acc ttc tct att gac ggt cac   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
            225                 230                 235
 
acc atg act atc atc gaa gct gat tct gtt aac acc cag ccg ctc gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtt gac tct atc cag atc ttc gcg gct caa cgt tac tct ttc gtt ctg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gac gct tct cag ccg gtt gac aac tat tgg att cgt gct aat ccg tct   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
270                 275                 280                 285
 
ttt ggc aac act ggt ttc gct ggt ggt atc aac tct gcg att ctg cgt   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tac gac ggt gct ccg gaa gtt gaa ccg acc acc act cag acc acc tct   962
Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser
            305                 310                 315
 
acc aaa ccg ctg aac gaa gtt gac ctg cac cca ctg act ccg atg gca   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala
        320                 325                 330
 
gtt cca ggt cgc cca gaa ccg ggt ggt gtt gac act ccg ctg aac atg   1058
Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met
    335                 340                 345
 
gtt ttc aac ttc aac ggt act aac ttc ttc atc aac gac cac tct ttc   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe
350                 355                 360                 365
 
gtt cca cca tct gtt cca gtt ctg ttg caa atc ctg tct ggt gcg cag   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct cag gac ctt gcg ccg tct ggc tct gtt tac gtt ctg ccg tcc   1202
Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser
            385                 390                 395
 
aac tcc tct atc gaa atc tct ttc cca gct acc gct aat gct cca ggc   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
gct ccg cat cca ttc cac ctg cac ggt cac acc ttc gcg gtt gtt cgc   1298
Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg
    415                 420                 425
 
tct gct ggt tct tct gaa tac aac tac gac aac ccg atc ttt cgt gat   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tcg acc ggt act cca ggt gac aac gtt acc atc cgt ttc caa   1394
Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln
                450                 455                 460
 
act aac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc cac   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ctg gat gcg ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac act   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
gct gct gcg aac cca gta ccg caa tct tgg tct gac ctg tgc ccg atc   1538
Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tac gac gct ctg gac cca tct gac ctg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 156
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 156
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 157
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 157
gaatactcca tatg atg tct cgt ttc caa tct ctg ctg tct ttc gtt ctc   50
                Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu
                 1               5                   10
 
gtg tct ctg gct gct gtt gct aat gcg gcg atc ggt cca atg gca gac   98
Val Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp
         15                  20                  25
 
ctg acc ctg acc aac gcg gct gtt agc ccg gac ggt ttc tct cgt gag   146
Leu Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu
     30                  35                  40
 
gcg gtt gtt gtt aac ggt caa act ccg ggt cca ctg atc gcg ggt cag   194
Ala Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln
 45                  50                  55                  60
 
aaa ggt gac cgt ttt cag ctg aac gtt att gac aac ctg acc aac cac   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His
                 65                  70                  75
 
acc atg ctg aaa acc acc tct atc cat tgg cac ggt ttc ttt cag cac   290
Thr Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His
             80                  85                  90
 
ggt act aat tgg gcg gac ggt cca gcg ttc atc aac cag tgc ccg att   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile
         95                 100                 105
 
gcg tct ggt cat tct ttc ctg tac gac ttt cag gtt ccg gac caa gct   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggc acc ttt tgg tat cac tct cac ctg tct acc cag tac tgc gat ggt   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ctg cgt ggt ccg ttc gtt gtt tac gac cca aac gac ccg cag gct tct   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser
                145                 150                 155
 
ctg tac gac att gac aac gac gac acc gtt atc acc ctg gtt gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp
            160                 165                 170
 
tat cac gtt gcg gcg aaa ctg ggt cca cgt ttt ccg ctg ggc gct gat   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp
        175                 180                 185
 
gct acc ctg atc aac ggc ctg ggt cgt tct ccg ggt act acc gct gcc   626
Ala Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala
    190                 195                 200
 
gac ctc gct gtt atc aaa gtt acc cag ggt aag cgt tac cgt ttt cgt   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
ctg gtt agc ctg tct tgc gac ccg aac cac acc ttc tct att gac ggt   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly
                225                 230                 235
 
cac acc atg act atc atc gaa gct gat tct gtt aac acc cag ccg ctc   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtt gac tct atc cag atc ttc gcg gct caa cgt tac tct ttc gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
ctg gac gct tct cag ccg gtt gac aac tat tgg att cgt gct aat ccg   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
tct ttt ggc aac act ggt ttc gct ggt ggt atc aac tct gcg att ctg   914
Ser Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
cgt tac gac ggt gct ccg gaa gtt gaa ccg acc acc act cag acc acc   962
Arg Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr
                305                 310                 315
 
tct acc aaa ccg ctg aac gaa gtt gac ctg cac cca ctg act ccg atg   1010
Ser Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met
            320                 325                 330
 
gca gtt cca ggt cgc cca gaa ccg ggt ggt gtt gac act ccg ctg aac   1058
Ala Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn
        335                 340                 345
 
atg gtt ttc aac ttc aac ggt act aac ttc ttc atc aac gac cac tct   1106
Met Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser
    350                 355                 360
 
ttc gtt cca cca tct gtt cca gtt ctg ttg caa atc ctg tct ggt gcg   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cag gct gct cag gac ctt gcg ccg tct ggc tct gtt tac gtt ctg ccg   1202
Gln Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro
                385                 390                 395
 
tcc aac tcc tct atc gaa atc tct ttc cca gct acc gct aat gct cca   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
ggc gct ccg cat cca ttc cac ctg cac ggt cac acc ttc gcg gtt gtt   1298
Gly Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val
        415                 420                 425
 
cgc tct gct ggt tct tct gaa tac aac tac gac aac ccg atc ttt cgt   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tcg acc ggt act cca ggt gac aac gtt acc atc cgt ttc   1394
Asp Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
caa act aac aat ccg ggt ccg tgg ttc ctg cac tgc cac att gac ttc   1442
Gln Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cac ctg gat gcg ggt ttc gcg gtt gtt atg gct gag gat acc ccg gac   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
act gct gct gcg aac cca gta ccg caa tct tgg tct gac ctg tgc ccg   1538
Thr Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
atc tac gac gct ctg gac cca tct gac ctg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 158
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 158
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 159
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 159
atg tct aga ttt caa tct tta ttg tct ttc gtt ttg gtt tca ttg gct   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gct gtt gct aac gct gca att gga cct atg gct gat ttg aca ttg act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gca gct gtt tct cca gat gga ttt tct aga gaa gct gtt gtt gtt   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aat gga caa act cct gga cca ttg att gct gga caa aaa gga gat aga   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttt caa tta aat gtt att gat aat ttg act aat cat act atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act act tct att cat tgg cat gga ttc ttt caa cat gga aca aat tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gct gat gga cct gct ttt att aat caa tgt cca att gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tca ttt ttg tat gat ttt cag gtt cca gat caa gca ggc act ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tct act cag tat tgt gat gga ttg aga gga cca   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttt gtt gtt tat gat cca aat gat cca cag gct tca ttg tat gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat act gtt att act tta gtt gat tgg tat cat gtt gca   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg gga cct aga ttt cca ttg gga gct gat gct act tta att   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aat gga ttg ggt aga tct cca ggt act act gct gct gat ttg gct gtt   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
att aaa gtt act caa gga aaa aga tat aga ttt aga ttg gtt tct tta   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat cca aat cat act ttt tct att gat gga cat act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
att att gaa gct gat tct gtt aat aca caa cca tta gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
att caa att ttt gca gct caa aga tat tct ttt gtt ttg gat gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att agg gct aac cca tct ttc gga aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
aca gga ttc gct gga gga att aat tct gct att ttg aga tat gat gga   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gca cca gag gtt gaa cca act act act caa act act tct act aag cca   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
tta aat gaa gtt gat ttg cac cca ttg act cct atg gca gtt cca ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
aga cca gaa cca gga gga gtt gat aca cct tta aat atg gtt ttt aat   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttt aat ggt act aat ttc ttt att aat gat cat tct ttt gtt cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt tta ttg caa att ttg tct ggt gct cag gct gct caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ttg gct cct agt gga tca gtt tat gtt ttg cca tct aat tct tct   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt cct gct act gct aac gct cct ggt gct cca cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
cca ttt cat ttg cac gga cat act ttt gca gtt gtt aga tca gct ggt   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gaa tat aat tat gat aat cca att ttt aga gat gtt gtt tct   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
aca ggt act cca ggt gat aat gtt act att aga ttt caa act aat aat   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttc gct gtt gtt atg gct gaa gat act cca gat act gcc gct gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aat cca gtt cct caa tct tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gat cca tct gat ttg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 160
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 160
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 161
<211> 1576
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1565)

<400> 161
tactcaagct t atg tct aga ttt caa tct tta ttg tct ttc gtt ttg gtt  50
             Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val
              1               5                   10
 
tca ttg gct gct gtt gct aac gct gca att gga cct atg gct gat ttg   98
Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu
     15                  20                  25
 
aca ttg act aat gca gct gtt tct cca gat gga ttt tct aga gaa gct   146
Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala
 30                  35                  40                  45
 
gtt gtt gtt aat gga caa act cct gga cca ttg att gct gga caa aaa   194
Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys
                 50                  55                  60
 
gga gat aga ttt caa tta aat gtt att gat aat ttg act aat cat act   242
Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr
             65                  70                  75
 
atg tta aaa act act tct att cat tgg cat gga ttc ttt caa cat gga   290
Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly
         80                  85                  90
 
aca aat tgg gct gat gga cct gct ttt att aat caa tgt cca att gct   338
Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala
     95                 100                 105
 
tct ggt cat tca ttt ttg tat gat ttt cag gtt cca gat caa gca ggc   386
Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly
110                 115                 120                 125
 
act ttt tgg tat cat tct cat ttg tct act cag tat tgt gat gga ttg   434
Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu
                130                 135                 140
 
aga gga cca ttt gtt gtt tat gat cca aat gat cca cag gct tca ttg   482
Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu
            145                 150                 155
 
tat gac att gat aat gat gat act gtt att act tta gtt gat tgg tat   530
Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr
        160                 165                 170
 
cat gtt gca gct aaa ttg gga cct aga ttt cca ttg gga gct gat gct   578
His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala
    175                 180                 185
 
act tta att aat gga ttg ggt aga tct cca ggt act act gct gct gat   626
Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp
190                 195                 200                 205
 
ttg gct gtt att aaa gtt act caa gga aaa aga tat aga ttt aga ttg   674
Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu
                210                 215                 220
 
gtt tct tta tct tgt gat cca aat cat act ttt tct att gat gga cat   722
Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His
            225                 230                 235
 
act atg act att att gaa gct gat tct gtt aat aca caa cca tta gaa   770
Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu
        240                 245                 250
 
gtt gat tct att caa att ttt gca gct caa aga tat tct ttt gtt ttg   818
Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu
    255                 260                 265
 
gat gct tct caa cca gtt gat aat tat tgg att agg gct aac cca tct   866
Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser
270                 275                 280                 285
 
ttc gga aat aca gga ttc gct gga gga att aat tct gct att ttg aga   914
Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg
                290                 295                 300
 
tat gat gga gca cca gag gtt gaa cca act act act caa act act tct   962
Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser
            305                 310                 315
 
act aag cca tta aat gaa gtt gat ttg cac cca ttg act cct atg gca   1010
Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala
        320                 325                 330
 
gtt cca ggt aga cca gaa cca gga gga gtt gat aca cct tta aat atg   1058
Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met
    335                 340                 345
 
gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat tct ttt   1106
Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe
350                 355                 360                 365
 
gtt cca cca tct gtt cca gtt tta ttg caa att ttg tct ggt gct cag   1154
Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln
                370                 375                 380
 
gct gct caa gat ttg gct cct agt gga tca gtt tat gtt ttg cca tct   1202
Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser
            385                 390                 395
 
aat tct tct att gaa att tct ttt cct gct act gct aac gct cct ggt   1250
Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly
        400                 405                 410
 
gct cca cat cca ttt cat ttg cac gga cat act ttt gca gtt gtt aga   1298
Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg
    415                 420                 425
 
tca gct ggt tct tct gaa tat aat tat gat aat cca att ttt aga gat   1346
Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp
430                 435                 440                 445
 
gtt gtt tct aca ggt act cca ggt gat aat gtt act att aga ttt caa   1394
Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln
                450                 455                 460
 
act aat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt cat   1442
Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His
            465                 470                 475
 
ttg gat gct ggt ttc gct gtt gtt atg gct gaa gat act cca gat act   1490
Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr
        480                 485                 490
 
gcc gct gct aat cca gtt cct caa tct tgg tct gat ttg tgt cca att   1538
Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile
    495                 500                 505
 
tat gat gct tta gat cca tct gat ttg gaattccgat g                  1576
Tyr Asp Ala Leu Asp Pro Ser Asp Leu
510                 515
 

<210> 162
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 162
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 163
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1568)

<400> 163
gaatactcca tatg atg tct aga ttt caa tct tta ttg tct ttc gtt ttg   50
                Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu
                 1               5                   10
 
gtt tca ttg gct gct gtt gct aac gct gca att gga cct atg gct gat   98
Val Ser Leu Ala Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp
         15                  20                  25
 
ttg aca ttg act aat gca gct gtt tct cca gat gga ttt tct aga gaa   146
Leu Thr Leu Thr Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu
     30                  35                  40
 
gct gtt gtt gtt aat gga caa act cct gga cca ttg att gct gga caa   194
Ala Val Val Val Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln
 45                  50                  55                  60
 
aaa gga gat aga ttt caa tta aat gtt att gat aat ttg act aat cat   242
Lys Gly Asp Arg Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His
                 65                  70                  75
 
act atg tta aaa act act tct att cat tgg cat gga ttc ttt caa cat   290
Thr Met Leu Lys Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His
             80                  85                  90
 
gga aca aat tgg gct gat gga cct gct ttt att aat caa tgt cca att   338
Gly Thr Asn Trp Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile
         95                 100                 105
 
gct tct ggt cat tca ttt ttg tat gat ttt cag gtt cca gat caa gca   386
Ala Ser Gly His Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala
    110                 115                 120
 
ggc act ttt tgg tat cat tct cat ttg tct act cag tat tgt gat gga   434
Gly Thr Phe Trp Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly
125                 130                 135                 140
 
ttg aga gga cca ttt gtt gtt tat gat cca aat gat cca cag gct tca   482
Leu Arg Gly Pro Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser
                145                 150                 155
 
ttg tat gac att gat aat gat gat act gtt att act tta gtt gat tgg   530
Leu Tyr Asp Ile Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp
            160                 165                 170
 
tat cat gtt gca gct aaa ttg gga cct aga ttt cca ttg gga gct gat   578
Tyr His Val Ala Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp
        175                 180                 185
 
gct act tta att aat gga ttg ggt aga tct cca ggt act act gct gct   626
Ala Thr Leu Ile Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala
    190                 195                 200
 
gat ttg gct gtt att aaa gtt act caa gga aaa aga tat aga ttt aga   674
Asp Leu Ala Val Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg
205                 210                 215                 220
 
ttg gtt tct tta tct tgt gat cca aat cat act ttt tct att gat gga   722
Leu Val Ser Leu Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly
                225                 230                 235
 
cat act atg act att att gaa gct gat tct gtt aat aca caa cca tta   770
His Thr Met Thr Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu
            240                 245                 250
 
gaa gtt gat tct att caa att ttt gca gct caa aga tat tct ttt gtt   818
Glu Val Asp Ser Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val
        255                 260                 265
 
ttg gat gct tct caa cca gtt gat aat tat tgg att agg gct aac cca   866
Leu Asp Ala Ser Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro
    270                 275                 280
 
tct ttc gga aat aca gga ttc gct gga gga att aat tct gct att ttg   914
Ser Phe Gly Asn Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu
285                 290                 295                 300
 
aga tat gat gga gca cca gag gtt gaa cca act act act caa act act   962
Arg Tyr Asp Gly Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr
                305                 310                 315
 
tct act aag cca tta aat gaa gtt gat ttg cac cca ttg act cct atg   1010
Ser Thr Lys Pro Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met
            320                 325                 330
 
gca gtt cca ggt aga cca gaa cca gga gga gtt gat aca cct tta aat   1058
Ala Val Pro Gly Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn
        335                 340                 345
 
atg gtt ttt aat ttt aat ggt act aat ttc ttt att aat gat cat tct   1106
Met Val Phe Asn Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser
    350                 355                 360
 
ttt gtt cca cca tct gtt cca gtt tta ttg caa att ttg tct ggt gct   1154
Phe Val Pro Pro Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala
365                 370                 375                 380
 
cag gct gct caa gat ttg gct cct agt gga tca gtt tat gtt ttg cca   1202
Gln Ala Ala Gln Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro
                385                 390                 395
 
tct aat tct tct att gaa att tct ttt cct gct act gct aac gct cct   1250
Ser Asn Ser Ser Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro
            400                 405                 410
 
ggt gct cca cat cca ttt cat ttg cac gga cat act ttt gca gtt gtt   1298
Gly Ala Pro His Pro Phe His Leu His Gly His Thr Phe Ala Val Val
        415                 420                 425
 
aga tca gct ggt tct tct gaa tat aat tat gat aat cca att ttt aga   1346
Arg Ser Ala Gly Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg
    430                 435                 440
 
gat gtt gtt tct aca ggt act cca ggt gat aat gtt act att aga ttt   1394
Asp Val Val Ser Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe
445                 450                 455                 460
 
caa act aat aat cct gga cct tgg ttt ttg cat tgt cat att gat ttt   1442
Gln Thr Asn Asn Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe
                465                 470                 475
 
cat ttg gat gct ggt ttc gct gtt gtt atg gct gaa gat act cca gat   1490
His Leu Asp Ala Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp
            480                 485                 490
 
act gcc gct gct aat cca gtt cct caa tct tgg tct gat ttg tgt cca   1538
Thr Ala Ala Ala Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro
        495                 500                 505
 
att tat gat gct tta gat cca tct gat ttg actagtcagt gcct           1582
Ile Tyr Asp Ala Leu Asp Pro Ser Asp Leu
    510                 515
 

<210> 164
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 164
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 165
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 165
atg tct aga ttc cag tct tta ttg tca ttc gtt ttg gtt tct tta gct   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gct gtt gct aat gct gct att ggt cct atg gct gat ttg act tta act   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aat gca gct gtg tct cct gat ggt ttc tct aga gaa gct gtt gtt gtt   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aac ggt caa act cca ggt cca ttg att gct ggt caa aaa ggt gat aga   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttc cag ctg aat gtt att gat aat ttg act aat cat act atg tta aaa   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
act act tct att cat tgg cat ggt ttc ttc cag cat gga act aat tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gct gat ggt cca gct ttc att aat caa tgt cca att gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ctc tat gat ttt caa gtt cca gat caa gct ggt aca ttc tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tct act caa tat tgt gat ggt ttg aga ggt cct   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttc gtt gtt tat gat cca aat gat cca cag gct tca ttg tat gac att   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat act gtt att aca ttg gtt gat tgg tat cat gtt gct   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gct aaa ttg ggt cca cgt ttt cca ttg ggt gca gat gct aca ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aac ggt ttg ggt aga tca cca ggt aca act gcg gcg gat ttg gct gtt   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
att aaa gtt act caa ggt aag aga tat aga ttc aga ttg gtt tca ttg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat cca aat cat act ttc tct att gat ggt cat act atg act   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
att att gaa gct gat tct gtt aat act caa cca ttg gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
att cag att ttc gca gca caa aga tat tct ttc gtt tta gat gct tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
caa cca gtt gat aat tat tgg att aga gct aat cca tct ttc ggt aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
act ggt ttc gct ggt gga att aat tct gct att ttg aga tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gct cca gaa gtt gaa cca act act act caa act act tct act aaa cca   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
tta aat gaa gtt gat ttg cat cca ttg act ccg atg gca gtt cca ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
aga cca gag ccg gga gga gtt gac act cca tta aat atg gtt ttc aat   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttc aat gga act aac ttc ttc att aat gat cat agt ttc gta cca cca   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
tct gtt cca gtt ttg ttg caa att ttg tct ggt gca caa gca gcc cag   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat ctc gca cca agc gga agt gtt tat gtt ttg cca tct aat tct tct   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttc cct gct act gct aac gcg cca gga gcc ccg cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
cct ttt cac ttg cat ggt cac acc ttc gct gta gtg aga tct gct ggt   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gaa tat aat tat gat aat cca att ttc aga gat gtt gtt tct   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
act ggt aca ccg ggt gat aat gtt act att aga ttt caa act aat aat   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
cct ggt cct tgg ttc ttg cac tgt cat att gat ttc cac ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggc ttt gcg gtt gtt atg gcc gaa gat act cca gat aca gcc gct gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aac cct gtt cct caa tct tgg tct gat ttg tgt cca att tat gat gct   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
ttg gac cct tct gat tta                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 166
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 166
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 167
<211> 1554
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1554)

<400> 167
atg tct cgt ttt cag tct ttg ttg tct ttt gtt ttg gtt tct ctt gcc   48
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                   10                  15
 
gcc gtt gct aat gct gct ata ggt ccg atg gcc gat ttg acc ttg acc   96
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
             20                  25                  30
 
aac gca gca gtg tct ccg gat ggt ttt tct cgt gag gcc gta gtt gtt   144
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
         35                  40                  45
 
aac ggt cag acc cca gga ccc ttg att gct ggt cag aaa ggt gat cgt   192
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
     50                  55                  60
 
ttt caa ctt aat gtc att gat aat ttg acg aat cat acc atg ttg aaa   240
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
 65                  70                  75                  80
 
acc acc tct att cat tgg cat ggc ttt ttc cag cat ggt acg aat tgg   288
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                 85                  90                  95
 
gct gat gga cct gct ttc att aat cag tgt ccg att gct tct ggt cat   336
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110
 
tct ttc ttg tat gat ttt cag gtt ccg gat cag gct ggt acg ttt tgg   384
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125
 
tat cat tct cat ttg tct acc cag tat tgt gat ggt ttg cgt ggt ccg   432
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140
 
ttt gtt gtt tat gat ccg aat gat ccg cag gcc tct ttg tat gat atc   480
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160
 
gat aat gat gat acc gtc att acc ttg gtt gat tgg tat cat gtt gca   528
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175
 
gca aaa ttg ggt ccg cgt ttt ccg ttg ggt gcc gat gca aca ttg att   576
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190
 
aat ggt ttg ggt cgt tct ccg ggt aca acc gct gct gat ttg gcc gtg   624
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205
 
att aaa gtt acc cag ggt aaa cgt tat cgt ttt cgt ttg gtt tct ttg   672
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220
 
tct tgt gat ccg aac cat acg ttt tct att gat ggt cat acg atg acg   720
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240
 
att att gag gct gat tct gtt aat acc cag ccg tta gaa gtt gat tct   768
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255
 
att cag att ttt gca gct cag cgt tat tct ttt gtc ttg gac gcc tct   816
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270
 
cag ccg gtt gat aat tat tgg att cgt gct aat ccg tct ttt ggt aat   864
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285
 
acc ggt ttt gct ggt ggc att aat tct gcc att ttg cgt tat gat ggt   912
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300
 
gcc cca gaa gtt gaa ccg acc act act cag acc acc tcg acc aaa cct   960
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320
 
ctt aat gaa gtt gat ctt cat ccg ttg acc cca atg gca gtt cct ggt   1008
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335
 
cgt cca gag cct ggt gga gtt gat acc ccg ttg aat atg gtt ttt aat   1056
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350
 
ttt aat ggc act aac ttc ttt att aat gat cat tct ttt gtt ccg cct   1104
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365
 
agt gtt ccg gta ttg ttg cag att ttg tct ggt gct caa gcc gcg caa   1152
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380
 
gat tta gct ccg tct ggt tct gtt tat gtt ttg ccg agc aat tct tct   1200
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400
 
att gaa att tct ttt ccg gcc aca gct aac gct cct ggc gct ccg cat   1248
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415
 
ccg ttt cat ctt cat ggt cat acc ttt gca gta gtc cgt tct gct ggg   1296
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430
 
tct tct gaa tat aat tat gat aat ccg att ttt cgt gat gtt gtt tct   1344
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445
 
acc ggt aca cct ggt gat aat gtt acg atc cgg ttt caa acc aac aat   1392
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460
 
ccg gga cca tgg ttt ttg cat tgt cat att gat ttt cat ttg gat gct   1440
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480
 
ggt ttt gcg gta gtt atg gct gaa gat acc cca gat aca gct gcc gct   1488
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495
 
aat cct gtt cct cag tct tgg tct gat ttg tgt ccc ata tat gac gcg   1536
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510
 
tta gac ccg tct gat ttg                                           1554
Leu Asp Pro Ser Asp Leu
        515
 

<210> 168
<211> 518
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 168
Met Ser Arg Phe Gln Ser Leu Leu Ser Phe Val Leu Val Ser Leu Ala
 1               5                  10                  15      
Ala Val Ala Asn Ala Ala Ile Gly Pro Met Ala Asp Leu Thr Leu Thr
            20                  25                  30          
Asn Ala Ala Val Ser Pro Asp Gly Phe Ser Arg Glu Ala Val Val Val
        35                  40                  45              
Asn Gly Gln Thr Pro Gly Pro Leu Ile Ala Gly Gln Lys Gly Asp Arg
    50                  55                  60                  
Phe Gln Leu Asn Val Ile Asp Asn Leu Thr Asn His Thr Met Leu Lys
65                  70                  75                  80  
Thr Thr Ser Ile His Trp His Gly Phe Phe Gln His Gly Thr Asn Trp
                85                  90                  95      
Ala Asp Gly Pro Ala Phe Ile Asn Gln Cys Pro Ile Ala Ser Gly His
            100                 105                 110         
Ser Phe Leu Tyr Asp Phe Gln Val Pro Asp Gln Ala Gly Thr Phe Trp
        115                 120                 125             
Tyr His Ser His Leu Ser Thr Gln Tyr Cys Asp Gly Leu Arg Gly Pro
    130                 135                 140                 
Phe Val Val Tyr Asp Pro Asn Asp Pro Gln Ala Ser Leu Tyr Asp Ile
145                 150                 155                 160 
Asp Asn Asp Asp Thr Val Ile Thr Leu Val Asp Trp Tyr His Val Ala
                165                 170                 175     
Ala Lys Leu Gly Pro Arg Phe Pro Leu Gly Ala Asp Ala Thr Leu Ile
            180                 185                 190         
Asn Gly Leu Gly Arg Ser Pro Gly Thr Thr Ala Ala Asp Leu Ala Val
        195                 200                 205             
Ile Lys Val Thr Gln Gly Lys Arg Tyr Arg Phe Arg Leu Val Ser Leu
    210                 215                 220                 
Ser Cys Asp Pro Asn His Thr Phe Ser Ile Asp Gly His Thr Met Thr
225                 230                 235                 240 
Ile Ile Glu Ala Asp Ser Val Asn Thr Gln Pro Leu Glu Val Asp Ser
                245                 250                 255     
Ile Gln Ile Phe Ala Ala Gln Arg Tyr Ser Phe Val Leu Asp Ala Ser
            260                 265                 270         
Gln Pro Val Asp Asn Tyr Trp Ile Arg Ala Asn Pro Ser Phe Gly Asn
        275                 280                 285             
Thr Gly Phe Ala Gly Gly Ile Asn Ser Ala Ile Leu Arg Tyr Asp Gly
    290                 295                 300                 
Ala Pro Glu Val Glu Pro Thr Thr Thr Gln Thr Thr Ser Thr Lys Pro
305                 310                 315                 320 
Leu Asn Glu Val Asp Leu His Pro Leu Thr Pro Met Ala Val Pro Gly
                325                 330                 335     
Arg Pro Glu Pro Gly Gly Val Asp Thr Pro Leu Asn Met Val Phe Asn
            340                 345                 350         
Phe Asn Gly Thr Asn Phe Phe Ile Asn Asp His Ser Phe Val Pro Pro
        355                 360                 365             
Ser Val Pro Val Leu Leu Gln Ile Leu Ser Gly Ala Gln Ala Ala Gln
    370                 375                 380                 
Asp Leu Ala Pro Ser Gly Ser Val Tyr Val Leu Pro Ser Asn Ser Ser
385                 390                 395                 400 
Ile Glu Ile Ser Phe Pro Ala Thr Ala Asn Ala Pro Gly Ala Pro His
                405                 410                 415     
Pro Phe His Leu His Gly His Thr Phe Ala Val Val Arg Ser Ala Gly
            420                 425                 430         
Ser Ser Glu Tyr Asn Tyr Asp Asn Pro Ile Phe Arg Asp Val Val Ser
        435                 440                 445             
Thr Gly Thr Pro Gly Asp Asn Val Thr Ile Arg Phe Gln Thr Asn Asn
    450                 455                 460                 
Pro Gly Pro Trp Phe Leu His Cys His Ile Asp Phe His Leu Asp Ala
465                 470                 475                 480 
Gly Phe Ala Val Val Met Ala Glu Asp Thr Pro Asp Thr Ala Ala Ala
                485                 490                 495     
Asn Pro Val Pro Gln Ser Trp Ser Asp Leu Cys Pro Ile Tyr Asp Ala
            500                 505                 510         
Leu Asp Pro Ser Asp Leu
        515             


<210> 169
<211> 1494
<212> DNA
<213> T. reesei

<220> 
<221> CDS            
<222> (1)...(1494)

<400> 169
atg cag tcg gcc tgc act ctc caa tcg gag act cac ccg cct ctg aca   48
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                   10                  15
 
tgg cag aaa tgc tcg tct ggt ggc act tgc act caa cag aca ggc tcc   96
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
             20                  25                  30
 
gtg gtc atc gac gcc aac tgg cgc tgg act cac gct acg aac agc agc   144
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
         35                  40                  45
 
acg aac tgc tac gat ggc aac act tgg agc tcg acc cta tgt cct gac   192
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
     50                  55                  60
 
aac gag acc tgc gcg aag aac tgc tgt ctg gac ggt gcc gcc tac gcg   240
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
 65                  70                  75                  80
 
tcc acg tac gga gtt acc acg agc ggt aac agc ctc tcc att ggc ttt   288
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                 85                  90                  95
 
gtc acc cag tct gcg cag aag aac gtt ggc gct cgc ctt tac ctt atg   336
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110
 
gcg agc gac acg acc tac cag gaa ttc acc ctg ctt ggc aac gag ttc   384
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125
 
tct ttc gat gtt gat gtt tcg cag ctg ccg tgc ggc ttg aac gga gct   432
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140
 
ctc tac ttc gtg tcc atg gac gcg gat ggt ggc gtg agc aag tat ccc   480
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160
 
acc aac acc gct ggc gcc aag tac ggc acg ggg tac tgt gac agc cag   528
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175
 
tgt ccc cgc gat ctg aag ttc atc aat ggc cag gcc aac gtt gag ggc   576
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190
 
tgg gag ccg tca tcc aac aac gca aac acg ggc att gga gga cac gga   624
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205
 
agc tgc tgc tct gag atg gat atc tgg gag gcc aac tcc atc tcc gag   672
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220
 
gct ctt acc ccc cac cct tgc acg act gtc ggc cag gag atc tgc gag   720
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240
 
ggt gat ggg tgc ggc gga act tac tcc gat aac aga tat ggc ggc act   768
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255
 
tgc gat ccc gat ggc tgc gac tgg aac cca tac cgc ctg ggc aac acc   816
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270
 
agc ttc tac ggc cct ggc tca agc ttt acc ctc gat acc acc aag aaa   864
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285
 
ttg acc gtt gtc acc cag ttc gag acg tcg ggt gcc atc aac cga tac   912
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300
 
tat gtc cag aat ggc gtc act ttc cag cag ccc aac gcc gag ctt ggt   960
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320
 
agt tac tct ggc aac gag ctc aac gat gat tac tgc aca gct gag gag   1008
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335
 
gca gaa ttc ggc gga tcc tct ttc tca gac aag ggc ggc ctg act cag   1056
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350
 
ttc aag aag gct acc tct ggc ggc atg gtt ctg gtc atg agt ctg tgg   1104
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365
 
gat gat tac tac gcc aac atg ctg tgg ctg gac tcc acc tac ccg aca   1152
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380
 
aac gag acc tcc tcc aca ccc ggt gcc gtg cgc gga agc tgc tcc acc   1200
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400
 
agc tcc ggt gtc cct gct cag gtc gaa tct cag tct ccc aac gcc aag   1248
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415
 
gtc acc ttc tcc aac atc aag ttc gga ccc att ggc agc acc ggc aac   1296
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430
 
cct agc ggc ggc aac cct ccc ggc gga aac cgt ggc acc acc acc acc   1344
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445
 
cgc cgc cca gcc act acc act gga agc tct ccc gga cct acc cag tct   1392
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460
 
cac tac ggc cag tgc ggc ggt att ggc tac agc ggc ccc acg gtc tgc   1440
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480
 
gcc agc ggc aca act tgc cag gtc ctg aac cct tac tac tct cag tgc   1488
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495
 
ctg taa                                                           1494
Leu  *

 

<210> 170
<211> 497
<212> PRT
<213> T. reesei

<400> 170
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                  10                  15      
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
            20                  25                  30          
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
        35                  40                  45              
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
    50                  55                  60                  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
65                  70                  75                  80  
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                85                  90                  95      
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110         
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125             
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140                 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160 
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175     
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190         
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205             
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220                 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240 
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255     
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270         
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285             
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300                 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320 
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335     
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350         
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365             
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380                 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400 
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415     
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430         
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445             
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460                 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480 
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495     
Leu
    


<210> 171
<211> 1491
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1491)

<400> 171
atg caa tct gct tgt acc ttg cag agt gag act cat cca cct ttg aca   48
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                   10                  15
 
tgg caa aaa tgt tct tct gga ggt act tgt act caa caa act ggt tct   96
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
             20                  25                  30
 
gtt gta att gat gct aat tgg aga tgg act cat gct aca aat tct tca   144
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
         35                  40                  45
 
act aat tgt tat gat ggt aat act tgg tct tca aca tta tgt cca gat   192
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
     50                  55                  60
 
aat gaa act tgt gct aaa aat tgt tgt ttg gat ggt gct gct tat gct   240
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
 65                  70                  75                  80
 
tct aca tac ggt gtt act act tct ggt aat tct ttg tct att ggt ttt   288
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                 85                  90                  95
 
gta act caa tct gcc caa aag aat gtt ggt gct aga ttg tat ttg atg   336
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110
 
gct tct gat act act tat caa gaa ttt act cta ttg ggt aat gaa ttt   384
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125
 
tct ttt gat gtt gat gtt tca caa ttg cct tgt ggt tta aat ggt gca   432
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140
 
ttg tat ttc gtt tca atg gat gct gat ggt gga gta tct aaa tat cca   480
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160
 
act aat act gct ggt gct aaa tat ggt act ggt tat tgt gat tca cag   528
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175
 
tgt cct aga gac tta aag ttt att aat ggt caa gct aat gtt gaa ggt   576
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190
 
tgg gaa cca tct tct aat aat gct aat act gga ata ggt ggt cat ggt   624
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205
 
tct tgt tgt tct gaa atg gac att tgg gaa gct aat tct att tct gag   672
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220
 
gct ttg act cca cat cca tgt act act gtt ggt caa gaa att tgt gaa   720
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240
 
ggt gat ggt tgt ggt ggt act tat tct gat aat aga tat ggt ggg acc   768
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255
 
tgt gat cca gat ggc tgt gat tgg aat cca tat aga ttg ggt aat act   816
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270
 
tct ttt tat ggt cca ggt tca tct ttt aca ttg gat act act aaa aag   864
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285
 
ttg act gtt gtt act caa ttt gaa act tct ggc gca att aat aga tat   912
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300
 
tat gtt caa aat ggt gtt acc ttt caa caa cca aat gct gaa ttg ggt   960
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320
 
tct tat tct ggt aat gaa ctt aac gat gat tat tgt act gct gaa gaa   1008
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335
 
gct gaa ttt gga ggt tct tct ttt tcc gat aaa gga ggt ttg act caa   1056
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350
 
ttt aag aag gca act tcg ggt ggt atg gtt ttg gtt atg tct ttg tgg   1104
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365
 
gat gat tat tat gct aat atg ttg tgg ctc gac tca act tat cca act   1152
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380
 
aac gaa act tct tct aca cca gga gca gtt aga ggt tcc tgt agt aca   1200
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400
 
tct tct ggg gtt cca gct caa gtt gaa tca caa agc cct aat gct aag   1248
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415
 
gtt act ttt tct aac att aaa ttt gga cca att ggc agt act ggt aac   1296
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430
 
cca tca ggt ggt aat cct cct ggc ggt aat aga ggt act act act act   1344
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445
 
agg aga cca gca act act act ggt tca tca ccg ggg cca act caa tct   1392
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460
 
cat tat ggt caa tgt gga gga ata ggt tat tct ggt cca acc gtt tgt   1440
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480
 
gct tct gga act aca tgt cag gtt tta aat cca tat tat tct cag tgt   1488
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495
 
ttg                                                               1491
Leu

 

<210> 172
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 172
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                  10                  15      
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
            20                  25                  30          
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
        35                  40                  45              
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
    50                  55                  60                  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
65                  70                  75                  80  
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                85                  90                  95      
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110         
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125             
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140                 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160 
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175     
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190         
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205             
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220                 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240 
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255     
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270         
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285             
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300                 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320 
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335     
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350         
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365             
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380                 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400 
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415     
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430         
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445             
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460                 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480 
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495     
Leu
    


<210> 173
<211> 1491
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1491)

<400> 173
atg cag tct gcg tgc acc ctc cag tct gaa acc cac ccg ccg ttg act   48
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                   10                  15
 
tgg cag aaa tgc tct tct ggt ggt act tgc acc cag cag acc ggc tct   96
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
             20                  25                  30
 
gtt gtt atc gat gcg aat tgg cgt tgg acc cac gcg acc aac tct tct   144
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
         35                  40                  45
 
acc aac tgc tac gac ggc aac act tgg tct tct acc ctg tgc ccg gac   192
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
     50                  55                  60
 
aac gaa acc tgc gcg aaa aac tgc tgc ctt gac ggc gct gcg tat gct   240
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
 65                  70                  75                  80
 
agc act tac ggc gtt acc acg tct ggt aac agc ctg tct atc ggt ttc   288
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                 85                  90                  95
 
gtt acc cag tcc gct caa aag aac gtt ggt gcg cgt ctg tac ctg atg   336
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110
 
gct tct gac acc acc tac cag gag ttc acc ctg ttg ggc aac gaa ttt   384
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125
 
tct ttc gac gtt gac gtg tcc cag ctg cca tgc ggt ttg aac ggt gcc   432
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140
 
ctg tac ttc gta agc atg gat gcg gat ggt ggc gtg agc aaa tac ccg   480
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160
 
acc aat acc gct ggt gct aag tac ggt act ggt tac tgc gac tct cag   528
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175
 
tgc cca cgt gac ttg aag ttc atc aac ggt caa gca aac gtt gaa ggt   576
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190
 
tgg gaa ccg tct tct aac aac gcg aac acc ggc atc ggt ggt cac ggt   624
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205
 
tct tgc tgc tct gaa atg gac att tgg gag gcg aac agc atc tct gaa   672
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220
 
gct ctg acc ccg cac ccg tgc act act gtt ggt cag gaa atc tgc gaa   720
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240
 
ggc gac ggt tgt ggc ggc acc tat agc gat aac cgt tat ggt ggt acg   768
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255
 
tgt gat ccg gac ggc tgt gat tgg aac ccg tac cgt ttg ggc aat acc   816
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270
 
tct ttc tac ggt cca ggc tct tct ttc acc ctg gac acc act aag aag   864
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285
 
ctg acc gtt gtt acc caa ttc gaa act tct ggc gcg atc aac cgc tac   912
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300
 
tac gtt cag aac ggt gtg act ttt cag cag cca aac gcg gaa ctg ggt   960
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320
 
tct tac tct ggt aac gaa ctg aac gac gac tac tgc acc gca gaa gaa   1008
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335
 
gct gag ttc ggt ggt agc tct ttc tct gac aaa ggt ggt ctg acc cag   1056
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350
 
ttc aaa aag gcg act agc ggt ggc atg gtt ctg gtt atg tct ctg tgg   1104
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365
 
gac gac tac tac gcg aat atg ctg tgg ctg gac tct acc tac ccg act   1152
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380
 
aac gaa act agc tct acc cca ggt gca gtc cgt ggt tct tgc agc acc   1200
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400
 
tcg agc ggc gtg ccg gct caa gta gaa tct cag tcc ccg aac gct aaa   1248
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415
 
gtt acc ttc tct aac atc aaa ttc ggc cct att ggt tcg acc ggt aac   1296
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430
 
ccg tct ggt ggt aat cct cca ggt ggt aat cgc ggt act acc act act   1344
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445
 
cgt cgc cct gcg acc acc act ggt tct agc cca ggc ccg acc caa tcc   1392
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460
 
cac tac ggt caa tgc ggt ggt att ggc tat agc ggt ccg act gtt tgc   1440
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480
 
gct tct ggc acg act tgt cag gtg ctt aac ccg tat tac tct caa tgt   1488
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495
 
ttg                                                               1491
Leu

 

<210> 174
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 174
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                  10                  15      
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
            20                  25                  30          
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
        35                  40                  45              
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
    50                  55                  60                  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
65                  70                  75                  80  
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                85                  90                  95      
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110         
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125             
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140                 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160 
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175     
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190         
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205             
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220                 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240 
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255     
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270         
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285             
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300                 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320 
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335     
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350         
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365             
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380                 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400 
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415     
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430         
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445             
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460                 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480 
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495     
Leu
    


<210> 175
<211> 1491
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1491)

<400> 175
atg caa tct gct tgt act tta caa tct gaa act cat cca cct ctc aca   48
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                   10                  15
 
tgg caa aaa tgt tct tct ggt ggt act tgt act caa caa act gga tct   96
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
             20                  25                  30
 
gtt gtt att gat gct aat tgg aga tgg act cat gct act aat tct tct   144
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
         35                  40                  45
 
act aat tgt tat gat gga aat act tgg tct tct aca ttg tgt cca gat   192
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
     50                  55                  60
 
aat gaa act tgt gct aaa aat tgt tgt ttg gat gga gct gct tat gct   240
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
 65                  70                  75                  80
 
tct act tat gga gtt act act tct gga aat tca ttg tct att gga ttt   288
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                 85                  90                  95
 
gtt act caa tct gca cag aaa aat gtt gga gct aga ttg tat ttg atg   336
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110
 
gct tct gat act act tat caa gaa ttt aca ttg ttg gga aat gaa ttt   384
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125
 
tct ttt gat gtt gat gtt tct caa ttg cct tgt gga tta aat gga gca   432
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140
 
ttg tat ttt gtt tct atg gat gct gat gga gga gtt tct aaa tat cca   480
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160
 
act aat act gct gga gct aaa tat ggt act gga tat tgt gat tct caa   528
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175
 
tgt cca agg gat tta aaa ttt att aat gga caa gct aat gtt gaa gga   576
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190
 
tgg gaa cca agt tct aat aac gct aat act gga att gga gga cat gga   624
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205
 
tct tgt tgt tct gaa atg gac att tgg gaa gct aat tct att tct gag   672
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220
 
gct ttg act cca cat cca tgt act act gtt gga caa gaa att tgt gaa   720
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240
 
gga gat ggt tgt ggt gga aca tat tct gat aat aga tat gga ggt aca   768
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255
 
tgt gat cca gat gga tgt gat tgg aat cca tat aga ttg gga aat act   816
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270
 
tct ttt tat gga cca gga tct tct ttt aca ttg gat act act aaa aag   864
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285
 
ttg act gtt gtt act cag ttc gag aca agt ggt gcc att aat aga tat   912
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300
 
tat gtt caa aat gga gtt acg ttc caa caa cca aat gca gaa ttg gga   960
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320
 
tct tat tct gga aat gaa tta aat gat gat tat tgt act gct gaa gaa   1008
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335
 
gct gaa ttt ggt gga tct agt ttt tca gat aaa gga gga ttg act caa   1056
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350
 
ttt aaa aag gct act tca ggc ggg atg gtt ttg gtt atg tct tta tgg   1104
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365
 
gat gat tat tat gct aat atg ttg tgg ttg gat tct act tat cca act   1152
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380
 
aac gaa act tct tct act cca gga gct gtt aga gga agt tgt agt act   1200
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400
 
tct tct ggg gtt cca gct caa gtt gaa tct caa tct cca aac gct aaa   1248
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415
 
gtt act ttt tct aac att aaa ttc gga cca att gga tct act gga aat   1296
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430
 
cca agt ggc ggt aac cct cct ggt ggg aat aga ggt act act act act   1344
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445
 
aga aga cca gct act act act gga agt tct cca ggc cca act caa tct   1392
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460
 
cat tat gga caa tgt gga gga att gga tat tct gga cca aca gtt tgt   1440
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480
 
gct tct gga aca act tgt caa gtt tta aat cca tat tat tct cag tgt   1488
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495
 
ttg                                                               1491
Leu

 

<210> 176
<211> 497
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 176
Met Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
 1               5                  10                  15      
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
            20                  25                  30          
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
        35                  40                  45              
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
    50                  55                  60                  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
65                  70                  75                  80  
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
                85                  90                  95      
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
            100                 105                 110         
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
        115                 120                 125             
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
    130                 135                 140                 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
145                 150                 155                 160 
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
                165                 170                 175     
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
            180                 185                 190         
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
        195                 200                 205             
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
    210                 215                 220                 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
225                 230                 235                 240 
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
                245                 250                 255     
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
            260                 265                 270         
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
        275                 280                 285             
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
    290                 295                 300                 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
305                 310                 315                 320 
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
                325                 330                 335     
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
            340                 345                 350         
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
        355                 360                 365             
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
    370                 375                 380                 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
385                 390                 395                 400 
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
                405                 410                 415     
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
            420                 425                 430         
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
        435                 440                 445             
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
    450                 455                 460                 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
465                 470                 475                 480 
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
                485                 490                 495     
Leu
    


<210> 177
<211> 1539
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1539)

<400> 177
atg tat aga aaa ttg gct gtt att tct gct ttc ttg gct act gct agg   48
Met Tyr Arg Lys Leu Ala Val Ile Ser Ala Phe Leu Ala Thr Ala Arg
 1               5                   10                  15
 
gct caa tct gct tgt act ctt caa tct gaa act cat cca cct ttg aca   96
Ala Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
             20                  25                  30
 
tgg caa aaa tgt tct tct ggt gga act tgt act caa caa act ggt tct   144
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
         35                  40                  45
 
gtt gtt att gat gct aat tgg aga tgg act cat gct act aat tct tct   192
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
     50                  55                  60
 
act aat tgt tat gat ggt aat act tgg tct tct act tta tgt cca gat   240
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
 65                  70                  75                  80
 
aat gaa act tgt gct aaa aat tgt tgt ttg gat ggt gct gct tat gct   288
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
                 85                  90                  95
 
tct act tat ggt gtt act act tct ggt aat tct tta tct att ggt ttc   336
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
            100                 105                 110
 
gtt act caa tca gca cag aaa aat gtt ggt gct aga ttg tat tta atg   384
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
        115                 120                 125
 
gct tct gat act act tat caa gaa ttt aca ttg ttg ggt aat gag ttc   432
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
    130                 135                 140
 
tct ttc gat gtt gat gtt tct caa ttg cct tgt ggt tta aat ggt gcg   480
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
145                 150                 155                 160
 
ctt tac ttc gtt tct atg gat gct gat ggt ggt gtt agt aaa tat cca   528
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
                165                 170                 175
 
aca aat act gct ggt gct aaa tat ggt aca ggt tat tgt gat tct caa   576
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
            180                 185                 190
 
tgt cct aga gat tta aaa ttc att aat ggt caa gct aat gtt gaa ggt   624
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
        195                 200                 205
 
tgg gaa cca tct tct aat aat gct aat act gga atc ggt ggt cat ggt   672
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
    210                 215                 220
 
tct tgt tgt tct gaa atg gat ata tgg gaa gct aat tct att tct gag   720
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
225                 230                 235                 240
 
gct ttg act cca cat cca tgt act act gtt ggt caa gaa att tgt gaa   768
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
                245                 250                 255
 
ggt gat ggt tgt ggt ggt aca tat tct gat aat aga tac gga gga acg   816
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
            260                 265                 270
 
tgt gat cca gac ggg tgt gat tgg aat cca tat aga ttg ggt aat act   864
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
        275                 280                 285
 
tct ttc tat ggt cct ggc agc tct ttt acg ctt gat act act aaa aag   912
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
    290                 295                 300
 
ttg act gtt gtt act caa ttc gaa act tct ggg gca att aat aga tat   960
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
305                 310                 315                 320
 
tat gtt caa aat gga gtt aca ttc cag caa cca aat gct gaa ttg ggt   1008
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
                325                 330                 335
 
tct tat tct ggt aat gaa tta aat gat gat tat tgt act gct gaa gaa   1056
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
            340                 345                 350
 
gct gag ttc ggc gga tct tct ttc tct gac aaa gga ggt ttg act caa   1104
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
        355                 360                 365
 
ttc aaa aag gct aca agt ggc ggt atg gtt ttg gtt atg tca ttg tgg   1152
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
    370                 375                 380
 
gat gat tat tat gct aat atg ttg tgg ctt gat tct act tat cca act   1200
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
385                 390                 395                 400
 
aat gaa act tct tct act cca ggt gca gtt aga ggt tca tgt agc act   1248
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
                405                 410                 415
 
tct tcc gga gtt cca gct caa gtt gaa tct caa tca cct aac gca aaa   1296
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
            420                 425                 430
 
gtt act ttc tct aat att aaa ttc ggt cca ata ggt tct act ggt aat   1344
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
        435                 440                 445
 
cca agc gga ggt aat cca cct ggc ggg aat aga ggt aca act act act   1392
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
    450                 455                 460
 
aga cgt cca gct act act act ggt agt tca cca ggt cca act caa tct   1440
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
465                 470                 475                 480
 
cat tat ggt caa tgt gga gga ata ggg tat tct ggt ccg acc gtg tgt   1488
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
                485                 490                 495
 
gct agt gga aca aca tgt caa gtt tta aac cca tat tat tct cag tgt   1536
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
            500                 505                 510
 
ttg                                                               1539
Leu

 

<210> 178
<211> 513
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 178
Met Tyr Arg Lys Leu Ala Val Ile Ser Ala Phe Leu Ala Thr Ala Arg
 1               5                  10                  15      
Ala Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
            20                  25                  30          
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
        35                  40                  45              
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
    50                  55                  60                  
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
65                  70                  75                  80  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
                85                  90                  95      
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
            100                 105                 110         
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
        115                 120                 125             
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
    130                 135                 140                 
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
145                 150                 155                 160 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
                165                 170                 175     
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
            180                 185                 190         
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
        195                 200                 205             
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
    210                 215                 220                 
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
225                 230                 235                 240 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
                245                 250                 255     
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
            260                 265                 270         
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
        275                 280                 285             
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
    290                 295                 300                 
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
305                 310                 315                 320 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
                325                 330                 335     
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
            340                 345                 350         
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
        355                 360                 365             
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
    370                 375                 380                 
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
385                 390                 395                 400 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
                405                 410                 415     
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
            420                 425                 430         
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
        435                 440                 445             
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
    450                 455                 460                 
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
465                 470                 475                 480 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
                485                 490                 495     
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
            500                 505                 510         
Leu
    


<210> 179
<211> 1539
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1539)

<400> 179
atg tat cgt aaa ttg gcc gtt atc tct gcg ttt ttg gcc acc gcc cgc   48
Met Tyr Arg Lys Leu Ala Val Ile Ser Ala Phe Leu Ala Thr Ala Arg
 1               5                   10                  15
 
gcc caa tct gct tgt acc ttg cag tct gaa acg cat ccg ccg ttg acc   96
Ala Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
             20                  25                  30
 
tgg cag aaa tgt tct tct ggt ggt acg tgt acc cag cag acg ggt tct   144
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
         35                  40                  45
 
gtt gtc att gat gct aat tgg cgt tgg aca cat gcc act aat tct tct   192
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
     50                  55                  60
 
acc aac tgt tat gat ggt aat acc tgg tct tct acc ttg tgt ccg gat   240
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
 65                  70                  75                  80
 
aat gaa acc tgt gcc aaa aat tgt tgt ttg gat ggt gcc gct tat gcc   288
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
                 85                  90                  95
 
tct acg tat ggt gtt acc acg tct ggt aat tct ttg tct att ggt ttt   336
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
            100                 105                 110
 
gtt acc cag tct gcc cag aaa aat gtt ggt gct cgt ttg tat ctt atg   384
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
        115                 120                 125
 
gcc tct gat acc acg tat cag gaa ttt acc ttg ttg ggt aat gaa ttt   432
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
    130                 135                 140
 
tct ttt gat gtt gat gtt tct cag ttg ccg tgt ggt ttg aat ggg gcc   480
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
145                 150                 155                 160
 
tta tat ttt gtt tct atg gac gct gat ggt ggt gtt tca aaa tat ccg   528
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
                165                 170                 175
 
acc aac aca gcg ggt gcc aaa tat ggt act gga tat tgt gat tct cag   576
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
            180                 185                 190
 
tgt ccg cgt gat ctc aaa ttt att aat ggt cag gct aat gtt gaa ggt   624
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
        195                 200                 205
 
tgg gaa ccg tct tca aat aat gct aat acc ggt ata ggt ggt cat ggt   672
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
    210                 215                 220
 
tct tgt tgt tct gaa atg gac att tgg gaa gct aat tct att tct gag   720
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
225                 230                 235                 240
 
gcc ctt acc cct cat cca tgt acc acc gtg ggt cag gaa att tgt gaa   768
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
                245                 250                 255
 
ggt gat ggt tgt ggt ggt act tat tct gat aat cgt tat ggc gga acc   816
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
            260                 265                 270
 
tgt gat ccg gat ggg tgt gat tgg aat ccg tat cgt ttg ggt aat acc   864
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
        275                 280                 285
 
tct ttt tat ggt ccg ggc tct tct ttt acc ttg gat acc acc aaa aag   912
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
    290                 295                 300
 
ttg acc gtt gtt acc caa ttt gaa acc tct gga gct ata aat cgt tat   960
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
305                 310                 315                 320
 
tat gtt cag aat ggt gtt acg ttt cag cag cct aat gcc gaa ttg ggt   1008
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
                325                 330                 335
 
tct tat tct ggt aat gaa ttg aat gat gat tat tgt acc gca gag gag   1056
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
            340                 345                 350
 
gct gaa ttt gga gga tct tct ttt tct gat aaa ggt ggt ttg acc cag   1104
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
        355                 360                 365
 
ttt aag aaa gcc acc agt gga ggt atg gtt ttg gtt atg tct ttg tgg   1152
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
    370                 375                 380
 
gat gat tat tat gcc aac atg ctt tgg ttg gat tct acg tat cct acg   1200
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
385                 390                 395                 400
 
aat gaa acc agt tct acc cca gga gct gtt cgt ggt agt tgt agc acc   1248
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
                405                 410                 415
 
tct tct ggc gtt ccg gca caa gtt gaa tct cag tct cct aac gca aaa   1296
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
            420                 425                 430
 
gtt acc ttt agc aat att aaa ttt ggt ccc att ggt tct acc ggt aat   1344
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
        435                 440                 445
 
ccg tcg ggt gga aat cct cca ggt ggg aat cgt gga acc act acg acg   1392
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
    450                 455                 460
 
cgt aga ccg gct acc act aca ggc tct tca ccg ggt ccg aca caa tct   1440
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
465                 470                 475                 480
 
cat tat ggt cag tgt gga gga ata ggt tat tct ggt cca acc gtc tgt   1488
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
                485                 490                 495
 
gct tct ggc acg aca tgt caa gtt ttg aat ccg tat tat tct caa tgt   1536
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
            500                 505                 510
 
ttg                                                               1539
Leu

 

<210> 180
<211> 513
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 180
Met Tyr Arg Lys Leu Ala Val Ile Ser Ala Phe Leu Ala Thr Ala Arg
 1               5                  10                  15      
Ala Gln Ser Ala Cys Thr Leu Gln Ser Glu Thr His Pro Pro Leu Thr
            20                  25                  30          
Trp Gln Lys Cys Ser Ser Gly Gly Thr Cys Thr Gln Gln Thr Gly Ser
        35                  40                  45              
Val Val Ile Asp Ala Asn Trp Arg Trp Thr His Ala Thr Asn Ser Ser
    50                  55                  60                  
Thr Asn Cys Tyr Asp Gly Asn Thr Trp Ser Ser Thr Leu Cys Pro Asp
65                  70                  75                  80  
Asn Glu Thr Cys Ala Lys Asn Cys Cys Leu Asp Gly Ala Ala Tyr Ala
                85                  90                  95      
Ser Thr Tyr Gly Val Thr Thr Ser Gly Asn Ser Leu Ser Ile Gly Phe
            100                 105                 110         
Val Thr Gln Ser Ala Gln Lys Asn Val Gly Ala Arg Leu Tyr Leu Met
        115                 120                 125             
Ala Ser Asp Thr Thr Tyr Gln Glu Phe Thr Leu Leu Gly Asn Glu Phe
    130                 135                 140                 
Ser Phe Asp Val Asp Val Ser Gln Leu Pro Cys Gly Leu Asn Gly Ala
145                 150                 155                 160 
Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro
                165                 170                 175     
Thr Asn Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln
            180                 185                 190         
Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Ala Asn Val Glu Gly
        195                 200                 205             
Trp Glu Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Gly His Gly
    210                 215                 220                 
Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Glu
225                 230                 235                 240 
Ala Leu Thr Pro His Pro Cys Thr Thr Val Gly Gln Glu Ile Cys Glu
                245                 250                 255     
Gly Asp Gly Cys Gly Gly Thr Tyr Ser Asp Asn Arg Tyr Gly Gly Thr
            260                 265                 270         
Cys Asp Pro Asp Gly Cys Asp Trp Asn Pro Tyr Arg Leu Gly Asn Thr
        275                 280                 285             
Ser Phe Tyr Gly Pro Gly Ser Ser Phe Thr Leu Asp Thr Thr Lys Lys
    290                 295                 300                 
Leu Thr Val Val Thr Gln Phe Glu Thr Ser Gly Ala Ile Asn Arg Tyr
305                 310                 315                 320 
Tyr Val Gln Asn Gly Val Thr Phe Gln Gln Pro Asn Ala Glu Leu Gly
                325                 330                 335     
Ser Tyr Ser Gly Asn Glu Leu Asn Asp Asp Tyr Cys Thr Ala Glu Glu
            340                 345                 350         
Ala Glu Phe Gly Gly Ser Ser Phe Ser Asp Lys Gly Gly Leu Thr Gln
        355                 360                 365             
Phe Lys Lys Ala Thr Ser Gly Gly Met Val Leu Val Met Ser Leu Trp
    370                 375                 380                 
Asp Asp Tyr Tyr Ala Asn Met Leu Trp Leu Asp Ser Thr Tyr Pro Thr
385                 390                 395                 400 
Asn Glu Thr Ser Ser Thr Pro Gly Ala Val Arg Gly Ser Cys Ser Thr
                405                 410                 415     
Ser Ser Gly Val Pro Ala Gln Val Glu Ser Gln Ser Pro Asn Ala Lys
            420                 425                 430         
Val Thr Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Gly Asn
        435                 440                 445             
Pro Ser Gly Gly Asn Pro Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr
    450                 455                 460                 
Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser
465                 470                 475                 480 
His Tyr Gly Gln Cys Gly Gly Ile Gly Tyr Ser Gly Pro Thr Val Cys
                485                 490                 495     
Ala Ser Gly Thr Thr Cys Gln Val Leu Asn Pro Tyr Tyr Ser Gln Cys
            500                 505                 510         
Leu
    


<210> 181
<211> 1008
<212> DNA
<213> T. aurantiacus

<220> 
<221> CDS            
<222> (1)...(1008)

<400> 181
atg aag ctc ggc tct ctc gtg ctc gct ctc agc gca gct agg ctt aca   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
ctg tcg gcc cct ctc gca gac aga aag cag gag acc aag cgt gcg aaa   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gta ttc caa tgg ttc ggt tcg aac gag tcc ggt gct gaa ttc gga agc   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
cag aac ctt cca gga gtc gag gga aag gat tat ata tgg cct gat ccc   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aac acc att gac aca ttg atc agc aag ggg atg aac atc ttt cgt gtc   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
ccc ttt atg atg gag aga ttg gtt ccc aac tca atg acc ggc tct ccg   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gat ccg aac tac ctg gca gat ctc ata gcg act gta aat gca atc acc   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
cag aaa ggt gcc tac gcc gtc gtc gat cct cat aac tac ggc aga tac   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tac aat tct ata atc tcg agc cct tcc gat ttc cag acc ttc tgg aaa   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
acg gtc gcc tca cag ttt gct tcg aat cca ctg gtc atc ttc gac act   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aat aac gaa tac cac gat atg gac cag acc tta gtc ctc aat ctc aac   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
cag gcc gct atc gac ggc atc cgt tcc gcc gga gcc act tcc cag tac   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
atc ttt gtc gag ggc aat tcg tgg acc ggg gca tgg acc tgg acg aac   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtg aac gat aac atg aaa agc ctg acc gac cca tct gac aag atc ata   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tac gag atg cac cag tac ctg gac tct gac gga tcc ggg aca tca gcg   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
acc tgc gta tct tcg acc atc ggt caa gag cga atc acc agc gca acg   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
cag tgg ctc agg gcc aac ggg aag aag ggc atc atc ggc gag ttt gcg   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
ggc gga gcc aac gac gtc tgc gag acg gcc atc acg ggc atg ctg gac   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tac atg gcc cag aac aca gac gtc tgg act ggc gcc atc tgg tgg gcg   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gcc ggg ccg tgg tgg gga gac tac ata ttc tcc atg gaa ccg gac aat   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
ggc atc gcg tat cag cag ata ctt cct att ttg act ccg tat ctt tga   1008
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu  *
                325                 330                 335
 


<210> 182
<211> 335
<212> PRT
<213> T. aurantiacus

<400> 182
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 183
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 183
atg aaa ttg ggt tct ttg gtt ttg gct ttg tct gct gct aga ttg aca   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
ttg tct gcc cca ttg gct gat aga aaa caa gaa act aaa aga gct aag   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gtt ttt caa tgg ttt gga tct aat gaa tct ggt gct gag ttc ggt tct   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
cag aat ttg cca ggc gta gaa gga aag gat tat att tgg cca gac cca   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aat act att gat aca ttg att tct aaa ggt atg aac att ttc aga gtt   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
cca ttt atg atg gaa aga ttg gtt cca aat tct atg act ggt tct cct   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gat cct aat tat ttg gcg gac ttg att gca act gtt aat gct att act   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
caa aaa ggt gct tat gct gtt gtt gat cct cac aat tat ggt aga tat   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tac aat tct att att tct tca cca tct gat ttt caa act ttt tgg aaa   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
act gtt gct tca caa ttt gct agt aac ccc ttg gtt ata ttc gac act   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aat aat gaa tat cat gat atg gat caa aca ttg gtt tta aac tta aat   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
caa gct gct att gat gga att aga tct gct gga gcc aca tca caa tat   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
att ttc gtt gaa ggg aac tct tgg aca ggt gca tgg act tgg aca aat   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtt aac gat aat atg aaa tct ttg act gat cca tct gac aaa att att   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tat gaa atg cat caa tat ttg gat tct gat ggt tct ggt act tct gca   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
act tgt gtt tca tca act att ggt caa gaa aga att act tca gcg acc   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
caa tgg tta aga gct aat ggt aaa aag gga ata att ggt gaa ttt gca   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
gga ggc gca aac gat gtt tgt gaa act gct att act ggt atg ttg gat   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tat atg gct caa aat act gat gtt tgg act ggc gcg atc tgg tgg gct   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gcg ggt cca tgg tgg ggc gac tat att ttc tca atg gaa cca gat aat   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
gga att gct tat caa caa att ttg cca att ttg act cca tat ttg       1005
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335
 


<210> 184
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 184
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 185
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 185
atg aaa ctg ggt tct ctg gtt ctg gct ctg tct gct gct cgt ctg acc   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
ctg tct gcg cct ttg gcg gac cgt aaa cag gaa acc aaa cgt gcg aaa   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gtt ttc caa tgg ttc ggt tct aac gaa tct ggt gcg gag ttc ggt agc   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
caa aac ctg ccg ggt gtt gaa ggt aaa gac tac att tgg ccg gac ccg   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aac acc atc gat acc ctg atc tct aaa ggt atg aac atc ttt cgt gtt   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
ccg ttc atg atg gaa cgt ctg gtt ccg aac tct atg acc ggt tct cca   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gat ccg aac tac ctc gcg gac ctg atc gct acc gtt aac gcg atc acc   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
cag aaa ggt gcg tat gcg gtt gtt gac ccg cac aac tac ggt cgt tac   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tac aac tct atc atc tct tct ccg tct gac ttc caa acc ttt tgg aaa   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
acc gtt gcg tct cag ttc gcg tct aat ccg ctg gtt atc ttc gac acc   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aac aac gaa tac cac gac atg gac cag acc ctg gtt ctg aac ctg aac   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
cag gct gcg att gac ggt atc cgt tct gcg ggt gcg acc tct cag tac   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
atc ttc gtt gaa ggt aac tct tgg acc ggt gct tgg act tgg acc aac   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtt aac gac aac atg aaa tct ctg acc gac ccg tct gat aaa atc atc   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tac gaa atg cac cag tac ctt gac tct gac ggt tct ggt act tct gcg   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
act tgc gtg tct tct acc atc ggt cag gaa cgt atc acc tct gcg acc   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
cag tgg ctc cgt gcg aac ggt aaa aag ggt atc atc ggt gaa ttt gcg   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
ggc ggc gcg aat gac gtt tgc gaa acc gct atc acg ggt atg ctg gac   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tac atg gct cag aac acc gac gtt tgg act ggc gct att tgg tgg gca   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gca ggt cct tgg tgg ggt gac tac atc ttc tct atg gaa ccg gac aac   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
ggc atc gcg tac cag cag atc ctg cct atc ctg acc ccg tac ctg       1005
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335
 


<210> 186
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 186
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 187
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 187
atg aaa ttg gga tct tta gtt ttg gct ttg tct gct gct aga ttg act   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
tta tct gcc cca ttg gct gac aga aaa caa gaa act aaa aga gct aaa   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gtt ttt caa tgg ttt ggt tct aat gaa tct ggt gct gaa ttt ggt tct   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
caa aat ttg cca gga gtt gaa ggt aag gac tat att tgg cca gat cca   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aac act att gat aca ttg att tct aaa gga atg aac att ttc aga gtt   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
ccc ttt atg atg gag aga ttg gtt cca aat tct atg act gga tca ccc   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gac cca aat tat tta gct gat ttg att gct act gtt aac gct att act   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
caa aaa gga gct tat gct gtt gtt gat ccc cac aat tat ggt aga tat   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tac aac tct att att tct tct cca agt gat ttt caa act ttt tgg aaa   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
act gtt gct tct caa ttc gct agt aac cct ctc gtt att ttc gac act   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aat aat gaa tat cat gat atg gac caa act tta gtt tta aac tta aat   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
caa gct gct att gat gga att aga tct gct gga gct act tct caa tac   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
atc ttt gtt gaa gga aat tct tgg act ggt gcc tgg act tgg aca aac   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtg aat gat aat atg aaa tca ttg act gat cca tct gac aaa att att   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tat gaa atg cat cag tac ttg gat tct gat gga tct gga aca tct gca   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
act tgt gtg tct tct act att gga caa gaa aga att act tcg gct act   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
caa tgg ttg cga gct aat ggc aaa aag ggc att att gga gaa ttt gca   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
gga gga gct aac gac gtt tgt gaa act gct att act gga atg ttg gat   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tat atg gct caa aat act gat gtt tgg act gga gct att tgg tgg gca   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gct ggg cca tgg tgg ggt gat tat att ttc tct atg gaa cca gat aac   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
ggt ata gca tac caa caa att ttg cca att ttg act cca tat ttg       1005
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335
 


<210> 188
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 188
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 189
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 189
atg aaa ttg ggt tca ttg gtt ttg gct ttg tct gct gct aga ttg aca   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
ttg tct gcg cca ttg gct gat aga aaa caa gaa act aaa aga gct aaa   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gtt ttc cag tgg ttc ggt tct aat gaa tct ggt gct gaa ttt ggt tct   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
caa aat ttg cca ggt gtt gaa ggt aag gat tat att tgg cca gat cca   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aac act att gat aca ttg att tct aag ggt atg aat att ttc aga gtt   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
cca ttc atg atg gaa aga ttg gtt cca aat tct atg act ggt tca cca   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gac cct aat tac ttg gct gac ttg att gct act gtt aat gct att act   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
caa aaa ggt gct tat gct gtt gtt gat ccg cat aat tat ggt aga tat   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tac aat tct att att tct tct cct tct gat ttc cag act ttc tgg aag   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
acc gtc gct tct caa ttc gct tcg aat cca ttg gtt att ttc gac act   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aat aat gaa tat cat gac atg gat caa act tta gtc ctt aat tta aac   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
caa gct gct ata gac gga att aga tct gct gga gct act tct caa tat   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
att ttc gtt gag gga aat tct tgg aca ggt gca tgg act tgg aca aac   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtg aat gat aat atg aaa tca ttg act gat cca tct gac aaa att att   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tat gaa atg cat caa tac ttg gat tct gat ggt tct ggt aca tct gct   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
aca tgt gtg tct tct act att ggt caa gaa aga att act tcc gca act   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
caa tgg ttg aga gct aat ggc aaa aag gga atc att ggc gag ttc gct   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
gga gga gcc aac gat gtt tgt gaa act gct att act ggt atg ttg gat   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tat atg gct caa aat act gat gtt tgg act gga gcg ata tgg tgg gcc   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gct ggt cct tgg tgg gga gat tat att ttc tct atg gaa cca gat aat   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
gga att gct tat caa caa att ttg cca att ttg act cca tat tta       1005
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335
 


<210> 190
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 190
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 191
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 191
atg aaa ttg ggt tct ttg gtt ttg gct ctt tct gcc gcc cgc ttg acc   48
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                   10                  15
 
ttg tct gcc ccg ttg gcc gat cgt aaa cag gaa acc aaa cgt gcc aaa   96
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
             20                  25                  30
 
gtt ttt cag tgg ttt ggt tct aat gaa tct ggt gcc gaa ttt ggt tct   144
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
         35                  40                  45
 
cag aat ttg ccg ggt gtc gag ggc aaa gat tat ata tgg cct gac cct   192
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
     50                  55                  60
 
aat acc att gat acc ttg att tct aaa ggt atg aat att ttt cgt gtt   240
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
 65                  70                  75                  80
 
ccg ttt atg atg gaa cgt ctt gta ccg aat agc atg acc ggt tct cct   288
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                 85                  90                  95
 
gat ccg aat tat ttg gct gac ttg att gcc acc gtt aat gcc att acc   336
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110
 
cag aaa ggt gct tat gcc gtt gtt gat ccg cat aat tat ggt cgt tat   384
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125
 
tat aat tct att att tct tct ccg tct gat ttt cag acc ttt tgg aaa   432
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140
 
acc gtt gcc tct cag ttt gcc tct aat ccg cta gtt atc ttt gat acg   480
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160
 
aat aat gaa tat cat gat atg gat cag acc ctg gtt ttg aat ttg aat   528
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175
 
cag gcc gca att gat ggt ata cgt tct gct ggt gct acc tca cag tat   576
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190
 
att ttt gtt gaa ggt aat tca tgg acc ggc gcg tgg acc tgg acc aac   624
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205
 
gtt aac gat aat atg aaa tct ttg acc gat ccg agc gac aaa att att   672
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220
 
tat gaa atg cat cag tat ttg gat tct gat ggt tct ggt aca tct gca   720
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240
 
aca tgt gtt tct tct acc att ggt cag gaa cgt att aca tcc gcc acc   768
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255
 
cag tgg ttg aga gct aat ggt aag aag ggc atc att ggt gaa ttt gca   816
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270
 
gga ggt gct aat gat gtc tgt gaa aca gct ata acc ggg atg ttg gat   864
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285
 
tat atg gcc cag aat acc gat gtt tgg acg gga gct atc tgg tgg gca   912
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300
 
gct ggt cct tgg tgg ggt gat tat att ttt agc atg gaa ccc gat aat   960
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320
 
ggc att gct tat caa cag att ttg ccc att ttg acg ccc tat ttg       1005
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335
 


<210> 192
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 192
Met Lys Leu Gly Ser Leu Val Leu Ala Leu Ser Ala Ala Arg Leu Thr
 1               5                  10                  15      
Leu Ser Ala Pro Leu Ala Asp Arg Lys Gln Glu Thr Lys Arg Ala Lys
            20                  25                  30          
Val Phe Gln Trp Phe Gly Ser Asn Glu Ser Gly Ala Glu Phe Gly Ser
        35                  40                  45              
Gln Asn Leu Pro Gly Val Glu Gly Lys Asp Tyr Ile Trp Pro Asp Pro
    50                  55                  60                  
Asn Thr Ile Asp Thr Leu Ile Ser Lys Gly Met Asn Ile Phe Arg Val
65                  70                  75                  80  
Pro Phe Met Met Glu Arg Leu Val Pro Asn Ser Met Thr Gly Ser Pro
                85                  90                  95      
Asp Pro Asn Tyr Leu Ala Asp Leu Ile Ala Thr Val Asn Ala Ile Thr
            100                 105                 110         
Gln Lys Gly Ala Tyr Ala Val Val Asp Pro His Asn Tyr Gly Arg Tyr
        115                 120                 125             
Tyr Asn Ser Ile Ile Ser Ser Pro Ser Asp Phe Gln Thr Phe Trp Lys
    130                 135                 140                 
Thr Val Ala Ser Gln Phe Ala Ser Asn Pro Leu Val Ile Phe Asp Thr
145                 150                 155                 160 
Asn Asn Glu Tyr His Asp Met Asp Gln Thr Leu Val Leu Asn Leu Asn
                165                 170                 175     
Gln Ala Ala Ile Asp Gly Ile Arg Ser Ala Gly Ala Thr Ser Gln Tyr
            180                 185                 190         
Ile Phe Val Glu Gly Asn Ser Trp Thr Gly Ala Trp Thr Trp Thr Asn
        195                 200                 205             
Val Asn Asp Asn Met Lys Ser Leu Thr Asp Pro Ser Asp Lys Ile Ile
    210                 215                 220                 
Tyr Glu Met His Gln Tyr Leu Asp Ser Asp Gly Ser Gly Thr Ser Ala
225                 230                 235                 240 
Thr Cys Val Ser Ser Thr Ile Gly Gln Glu Arg Ile Thr Ser Ala Thr
                245                 250                 255     
Gln Trp Leu Arg Ala Asn Gly Lys Lys Gly Ile Ile Gly Glu Phe Ala
            260                 265                 270         
Gly Gly Ala Asn Asp Val Cys Glu Thr Ala Ile Thr Gly Met Leu Asp
        275                 280                 285             
Tyr Met Ala Gln Asn Thr Asp Val Trp Thr Gly Ala Ile Trp Trp Ala
    290                 295                 300                 
Ala Gly Pro Trp Trp Gly Asp Tyr Ile Phe Ser Met Glu Pro Asp Asn
305                 310                 315                 320 
Gly Ile Ala Tyr Gln Gln Ile Leu Pro Ile Leu Thr Pro Tyr Leu
                325                 330                 335 


<210> 193
<211> 678
<212> DNA
<213> T. lanuguinosus

<220> 
<221> CDS            
<222> (1)...(678)

<400> 193
atg gtc ggc ttt acc ccc gtt gcc ctt gcg gcc tta gcc gcg act ggg   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gcc ctg gcc ttc ccg gca ggg aat gcc acg gag ctc gaa aag cga cag   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
aca acc ccc aac tcg gag ggc tgg cac gat ggt tat tac tat tcc tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg agt gac ggt gga gcg cag gcc acg tac acc aac ctg gaa ggc ggc   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
acc tac gag atc agc tgg gga gat ggc ggt aac ctc gtc ggt gga aag   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
ggc tgg aac ccc ggc ctg aac gca aga gcc atc cac ttt gag ggt gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tac cag cca aac ggc aac agc tac ctt gcg gtc tac ggt tgg acc cgc   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aac ccg ctg gtc gag tat tac atc gtc gag aac ttt ggc acc tat gat   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
cct tcc tcc ggt gct acc gat cta gga act gtc gag tgc gac ggt agc   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
atc tat cga ctc ggc aag acc act cgc gtc aac gca cct agc atc gac   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
ggc acc caa acc ttc gac caa tac tgg tcg gtc cgc cag gac aag cgc   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
acc agc ggt acc gtc cag acg ggc tgc cac ttc gac gcc tgg gct cgc   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct ggt ttg aat gtc aac ggt gac cac tac tac cag atc gtt gca acg   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gag ggc tac ttc agc agc ggc tat gct cgc atc acc gtt gct gac gtg   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
ggc taa                                                           678
Gly  *
225
 

<210> 194
<211> 225
<212> PRT
<213> T. lanuguinosus

<400> 194
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 


<210> 195
<211> 675
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(675)

<400> 195
atg gtt ggt ttt act cca gtt gca ttg gct gct tta gct gca aca ggt   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gct ttg gca ttt cca gca ggt aac gct aca gaa ttg gaa aag agg caa   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
act act cca aat tct gaa ggt tgg cat gat ggt tat tat tat tct tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg tct gat ggt ggt gct caa gca act tat act aat ttg gaa ggt ggt   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
act tac gaa att tct tgg ggt gac gga ggt aat ttg gtt gga ggg aaa   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
ggt tgg aat cca ggt tta aat gct aga gct att cat ttt gaa ggt gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tat caa cca aat ggt aat tct tat ttg gct gtt tat ggt tgg act aga   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aat cca ttg gtt gaa tat tat att gtt gaa aat ttc ggt act tat gat   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
cca tct tct ggt gct aca gat ctt ggt aca gtt gaa tgt gat ggt tct   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
att tat aga ttg ggt aaa act act aga gtt aat gct cca tct att gac   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
ggt act caa act ttt gat caa tat tgg tct gtt aga caa gat aaa aga   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
act tct ggt act gtt caa act ggt tgt cat ttt gat gct tgg gct agg   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct ggt tta aat gtt aat ggt gat cat tat tat caa att gtt gca act   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gaa ggt tat ttt tca tct ggt tat gct aga att act gtt gct gat gtt   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
gga                                                               675
Gly
225
 

<210> 196
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 196
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 


<210> 197
<211> 675
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(675)

<400> 197
atg gtt ggt ttc acc ccg gtt gct ctc gcg gct ctg gct gct acc ggt   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gcg ctc gct ttc cct gcg ggt aac gcg acg gaa ctc gaa aaa cgt cag   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
acc acc ccg aac tct gaa ggt tgg cac gac ggt tac tac tac tct tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg tcg gat ggt ggt gca cag gct acc tac acc aac ctg gag ggt ggc   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
acc tac gaa atc tct tgg ggt gac ggt ggt aac ctg gtt ggt ggt aaa   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
ggt tgg aac ccg ggc ctg aac gct cgt gcg atc cac ttc gaa ggt gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tac cag ccg aac ggt aac tct tac ctg gct gtt tac ggt tgg acc cgt   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aac ccg ctg gtt gaa tac tac atc gtt gaa aac ttc ggt act tac gac   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
ccg tcc tct ggt gcg acc gac ctg ggc acc gtt gaa tgc gac ggt tct   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
atc tac cgt ctg ggt aaa acc acc cgt gtt aac gcg cca tct att gac   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
ggt act cag acc ttc gac cag tat tgg tct gtt cgt cag gac aaa cgt   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
acc tct ggt act gtg cag acc ggt tgt cac ttc gac gcg tgg gct cgc   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct ggc ttg aat gtt aac ggc gac cac tac tac cag atc gtt gcg act   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gaa ggt tac ttc tct tct ggt tac gcc cgt atc acc gtt gcg gat gtt   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
ggt                                                               675
Gly
225
 

<210> 198
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 198
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 


<210> 199
<211> 675
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(675)

<400> 199
atg gtt gga ttt act cca gtt gct tta gct gct ttg gct gca acg ggt   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gcc ttg gct ttt cca gca ggg aac gca act gaa tta gaa aag aga caa   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
act act cca aat tct gaa gga tgg cat gat gga tat tat tat tct tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg tct gat gga ggt gct caa gct act tat act aat tta gaa gga gga   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
aca tac gaa att tct tgg gga gat ggt gga aat ttg gtt gga gga aaa   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
gga tgg aac cca gga tta aat gca aga gct att cat ttc gaa gga gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tat caa cca aat gga aat tct tat ttg gcc gtt tat gga tgg act aga   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aat cca ctc gtt gaa tat tat att gtt gaa aat ttc ggt act tat gat   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
cca tct tct gga gct act gat ttg gga aca gtg gaa tgt gat gga tct   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
att tat aga ttg gga aaa act act aga gtt aat gca cct tct att gat   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
ggc act caa act ttt gat caa tat tgg tct gtt aga caa gat aaa aga   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
act tct ggt act gtt caa act gga tgt cat ttt gat gct tgg gct agg   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct gga tta aat gtg aat gga gat cat tat tat caa att gtt gct aca   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gaa gga tat ttt tca tct gga tat gct aga att act gtt gct gat gtt   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
gga                                                               675
Gly
225
 

<210> 200
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 200
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 


<210> 201
<211> 675
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(675)

<400> 201
atg gtt ggt ttc act cca gtt gct ttg gct gct tta gct gca acg ggt   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gca tta gct ttc cct gct ggt aat gct act gaa ttg gag aag aga caa   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
act act cca aat tct gaa ggt tgg cat gat ggt tat tat tat tct tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg tct gat ggt ggt gct caa gct act tat act aat ttg gaa ggt gga   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
acg tat gaa att tct tgg ggt gat ggc gga aat ttg gtt gga ggg aag   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
ggt tgg aat cca ggt tta aat gct aga gca att cat ttt gaa ggt gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tat caa cca aat ggt aat tct tat tta gct gtt tat ggg tgg act aga   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aat cca ttg gtt gaa tat tat att gtt gaa aat ttc gga act tat gat   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
cca tca tct ggt gct aca gat tta ggt aca gtt gaa tgt gat ggt tct   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
att tat aga ttg ggt aag act act aga gtt aat gct cca tct att gac   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
gga act caa act ttc gat caa tat tgg tct gtt aga caa gac aaa aga   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
act tct ggt aca gtc caa act ggt tgt cat ttt gat gct tgg gct cgt   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct ggt tta aat gtt aat ggt gat cat tat tat caa att gtt gcc act   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gaa gga tac ttc tct tct ggt tat gct aga att act gtt gct gat gtt   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
gga                                                               675
Gly
225
 

<210> 202
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 202
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 


<210> 203
<211> 675
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(675)

<400> 203
atg gtt ggt ttt acc ccg gtt gct ctt gcc gcc ctt gct gca aca ggt   48
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                   10                  15
 
gct cta gcg ttt ccg gct ggt aat gct acc gaa ttg gaa aaa cgt cag   96
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
             20                  25                  30
 
acc acc ccg aat agc gaa ggt tgg cat gat ggt tat tat tat tct tgg   144
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
         35                  40                  45
 
tgg tcg gat ggt ggt gcc cag gcc acg tat acg aat ttg gaa ggt ggc   192
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
     50                  55                  60
 
acg tat gaa att tct tgg ggt gat ggt ggc aat ttg gtt ggt ggt aaa   240
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
 65                  70                  75                  80
 
ggt tgg aat ccg ggc ttg aat gct cgt gca att cat ttt gaa ggt gtt   288
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                 85                  90                  95
 
tat cag ccg aat ggt aat tct tat ttg gcc gtt tat ggt tgg acg cgt   336
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110
 
aat ccg ttg gtt gaa tat tat att gtt gaa aat ttt ggt acg tat gat   384
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125
 
ccg tct tct ggc gca aca gat ttg ggc act gtt gaa tgt gat ggt tct   432
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140
 
att tat cgt ttg ggt aaa acg acg aga gtt aat gcc ccg tct att gat   480
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160
 
ggc acc cag acg ttt gat cag tat tgg tct gtt cgt cag gat aaa cgt   528
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175
 
acc tct ggc acg gtc cag act ggt tgt cat ttt gat gct tgg gcc cgc   576
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190
 
gct ggt ttg aat gtt aac ggt gat cat tat tat cag att gtt gcc aca   624
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205
 
gaa ggt tat ttt tct tct ggt tat gcc aga att acc gtt gcc gat gtt   672
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220
 
ggt                                                               675
Gly
225
 

<210> 204
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 204
Met Val Gly Phe Thr Pro Val Ala Leu Ala Ala Leu Ala Ala Thr Gly
 1               5                  10                  15      
Ala Leu Ala Phe Pro Ala Gly Asn Ala Thr Glu Leu Glu Lys Arg Gln
            20                  25                  30          
Thr Thr Pro Asn Ser Glu Gly Trp His Asp Gly Tyr Tyr Tyr Ser Trp
        35                  40                  45              
Trp Ser Asp Gly Gly Ala Gln Ala Thr Tyr Thr Asn Leu Glu Gly Gly
    50                  55                  60                  
Thr Tyr Glu Ile Ser Trp Gly Asp Gly Gly Asn Leu Val Gly Gly Lys
65                  70                  75                  80  
Gly Trp Asn Pro Gly Leu Asn Ala Arg Ala Ile His Phe Glu Gly Val
                85                  90                  95      
Tyr Gln Pro Asn Gly Asn Ser Tyr Leu Ala Val Tyr Gly Trp Thr Arg
            100                 105                 110         
Asn Pro Leu Val Glu Tyr Tyr Ile Val Glu Asn Phe Gly Thr Tyr Asp
        115                 120                 125             
Pro Ser Ser Gly Ala Thr Asp Leu Gly Thr Val Glu Cys Asp Gly Ser
    130                 135                 140                 
Ile Tyr Arg Leu Gly Lys Thr Thr Arg Val Asn Ala Pro Ser Ile Asp
145                 150                 155                 160 
Gly Thr Gln Thr Phe Asp Gln Tyr Trp Ser Val Arg Gln Asp Lys Arg
                165                 170                 175     
Thr Ser Gly Thr Val Gln Thr Gly Cys His Phe Asp Ala Trp Ala Arg
            180                 185                 190         
Ala Gly Leu Asn Val Asn Gly Asp His Tyr Tyr Gln Ile Val Ala Thr
        195                 200                 205             
Glu Gly Tyr Phe Ser Ser Gly Tyr Ala Arg Ile Thr Val Ala Asp Val
    210                 215                 220                 
Gly
225 

